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The anti-diabetic effects and pharmacokinetic profiles of bis(maltolato)oxovanadium in non-diabetic and diabetic rats
Zhang, Shuang-Qing1; Zhong, Xu-Ying1; Chen, Guo-Hua2; Lu, Wan-Liang1; Zhang, Qiang1
刊名JOURNAL OF PHARMACY AND PHARMACOLOGY
2008
DOI10.1211/jpp.60.1.0013
60期:1页:99-105
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]VANADIUM COMPOUNDS ; IN-VIVO ; COMPLEXES ; VANADATE ; MELLITUS ; SULFATE ; INHIBITOR ; LIGANDS ; MALTOL
英文摘要

The purpose of this study was to evaluate the anti-diabetic effects and pharmacokinetics of bis(maltolato)oxovanadium (BMOV) in rats. The anti-diabetic study was carried out in non-diabetic and diabetic rats by single-dose subcutaneous and intragastric administration. Pharmacokinetic investigation was performed using non-diabetic rats. Results showed that BMOV significantly decreased plasma glucose levels in diabetic rats at all given doses, and restored hyperglycaemic values to normal values after subcutaneous injections at doses of 4 and 8 mg vanadium (V)/kg or after intragastric administration at doses of 14 and 28 mgV/kg, respectively, but did not affect the plasma glucose level in non-diabetic rats. BMOV could be rapidly absorbed, slowly eliminated from plasma, widely distributed in various tissues and accumulated to a greater extent in the femur tissue. The average absolute bioavailability for intragastric administration at a single dose of 3, 6 and 12 mgV/kg was 28.1%, 33.7% and 21.4%, respectively. The presence of the peak vanadium level in the plasma was not coincident with that of the maximum effect of lowering plasma glucose levels. in conclusion, at the present dosing levels and administration routes, BMOV was effective in lowering plasma glucose levels in diabetic rats. BMOV has a promising outlook as an oral glucose-lowering drug.

语种英语
WOS记录号WOS:000253152500013
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60581
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100081, Peoples R China
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GB/T 7714
Zhang, Shuang-Qing,Zhong, Xu-Ying,Chen, Guo-Hua,et al. The anti-diabetic effects and pharmacokinetic profiles of bis(maltolato)oxovanadium in non-diabetic and diabetic rats[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY,2008,60(1):99-105.
APA Zhang, Shuang-Qing,Zhong, Xu-Ying,Chen, Guo-Hua,Lu, Wan-Liang,&Zhang, Qiang.(2008).The anti-diabetic effects and pharmacokinetic profiles of bis(maltolato)oxovanadium in non-diabetic and diabetic rats.JOURNAL OF PHARMACY AND PHARMACOLOGY,60(1),99-105.
MLA Zhang, Shuang-Qing,et al."The anti-diabetic effects and pharmacokinetic profiles of bis(maltolato)oxovanadium in non-diabetic and diabetic rats".JOURNAL OF PHARMACY AND PHARMACOLOGY 60.1(2008):99-105.
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