IR@PKUHSC  > 北京大学第三临床医学院  > 超声诊断科
学科主题临床医学
The fabrication of novel nanobubble ultrasound contrast agent for potential tumor imaging
Xing, Zhanwen1; Wang, Jinrui2; Ke, Hengte1; Zhao, Bo2; Yue, Xiuli1; Dai, Zhifei1; Liu, Jibin3
刊名NANOTECHNOLOGY
2010-04-09
DOI10.1088/0957-4484/21/14/145607
21期:14
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]GLASS SPG MEMBRANES ; THERAPEUTIC ARTERIOGENESIS ; ACOUSTIC EMULSIFICATION ; ENHANCED PERMEABILITY ; FILLED MICROBUBBLES ; SOLID TUMORS ; WATER ; DELIVERY ; DRUG ; ECHOCARDIOGRAPHY
英文摘要

Novel biocompatible nanobubbles were fabricated by ultrasonication of a mixture of Span 60 and polyoxyethylene 40 stearate (PEG40S) followed by differential centrifugation to isolate the relevant subpopulation from the parent suspensions. Particle sizing analysis and optical microscopy inspection indicated that the freshly generated micro/nanobubble suspension was polydisperse and the size distribution was bimodal with large amounts of nanobubbles. To develop a nano-sized contrast agent that is small enough to leak through tumor pores, a fractionation to extract smaller bubbles by variation in the time of centrifugation at 20g (relative centrifuge field, RCF) was suggested. The results showed that the population of nanobubbles with a precisely controlled mean diameter could be sorted from the initial polydisperse suspensions to meet the specified requirements. The isolated bubbles were stable over two weeks under the protection of perfluoropropane gas. The acoustic behavior of the nano-sized contrast agent was evaluated using power Doppler imaging in a normal rabbit model. An excellent power Doppler enhancement was found in vivo renal imaging after intravenous injection of the obtained nanobubbles. Given the broad spectrum of potential clinical applications, the nano-sized contrast agent may provide a versatile adjunct for ultrasonic imaging enhancement and/or treatment of tumors.

语种英语
WOS记录号WOS:000275652200033
Citation statistics
Cited Times:75[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60582
Collection北京大学第三临床医学院_超声诊断科
作者单位1.Harbin Inst Technol, State Key Lab Urban Water Resources & Environm, Sch Sci, Nanobiotechnol Div, Harbin 150080, Peoples R China
2.Peking Univ, Hosp 3, Dept Ultrasonog, Beijing 100083, Peoples R China
3.Thomas Jefferson Univ, Ultrasound Res & Educ Inst, Philadelphia, PA 19107 USA
Recommended Citation
GB/T 7714
Xing, Zhanwen,Wang, Jinrui,Ke, Hengte,et al. The fabrication of novel nanobubble ultrasound contrast agent for potential tumor imaging[J]. NANOTECHNOLOGY,2010,21(14).
APA Xing, Zhanwen.,Wang, Jinrui.,Ke, Hengte.,Zhao, Bo.,Yue, Xiuli.,...&Liu, Jibin.(2010).The fabrication of novel nanobubble ultrasound contrast agent for potential tumor imaging.NANOTECHNOLOGY,21(14).
MLA Xing, Zhanwen,et al."The fabrication of novel nanobubble ultrasound contrast agent for potential tumor imaging".NANOTECHNOLOGY 21.14(2010).
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