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学科主题临床医学
The fabrication of novel nanobubble ultrasound contrast agent for potential tumor imaging
Xing, Zhanwen1; Wang, Jinrui2; Ke, Hengte1; Zhao, Bo2; Yue, Xiuli1; Dai, Zhifei1; Liu, Jibin3
刊名NANOTECHNOLOGY
2010-04-09
DOI10.1088/0957-4484/21/14/145607
21期:14
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
资助者National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; Cultivation Fund of the Key Scientific and Technical Innovation Project ; Ministry of Education of China ; State Key Laboratory of Urban Water Resource and Environment ; National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; Cultivation Fund of the Key Scientific and Technical Innovation Project ; Ministry of Education of China ; State Key Laboratory of Urban Water Resource and Environment
研究领域[WOS]Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]GLASS SPG MEMBRANES ; THERAPEUTIC ARTERIOGENESIS ; ACOUSTIC EMULSIFICATION ; ENHANCED PERMEABILITY ; FILLED MICROBUBBLES ; SOLID TUMORS ; WATER ; DELIVERY ; DRUG ; ECHOCARDIOGRAPHY
英文摘要

Novel biocompatible nanobubbles were fabricated by ultrasonication of a mixture of Span 60 and polyoxyethylene 40 stearate (PEG40S) followed by differential centrifugation to isolate the relevant subpopulation from the parent suspensions. Particle sizing analysis and optical microscopy inspection indicated that the freshly generated micro/nanobubble suspension was polydisperse and the size distribution was bimodal with large amounts of nanobubbles. To develop a nano-sized contrast agent that is small enough to leak through tumor pores, a fractionation to extract smaller bubbles by variation in the time of centrifugation at 20g (relative centrifuge field, RCF) was suggested. The results showed that the population of nanobubbles with a precisely controlled mean diameter could be sorted from the initial polydisperse suspensions to meet the specified requirements. The isolated bubbles were stable over two weeks under the protection of perfluoropropane gas. The acoustic behavior of the nano-sized contrast agent was evaluated using power Doppler imaging in a normal rabbit model. An excellent power Doppler enhancement was found in vivo renal imaging after intravenous injection of the obtained nanobubbles. Given the broad spectrum of potential clinical applications, the nano-sized contrast agent may provide a versatile adjunct for ultrasonic imaging enhancement and/or treatment of tumors.

语种英语
所属项目编号NSFC-30970829 ; 30672001 ; 2007AA03Z316 ; 707021 ; HIT-2008QN06
资助者National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; Cultivation Fund of the Key Scientific and Technical Innovation Project ; Ministry of Education of China ; State Key Laboratory of Urban Water Resource and Environment ; National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; Cultivation Fund of the Key Scientific and Technical Innovation Project ; Ministry of Education of China ; State Key Laboratory of Urban Water Resource and Environment
WOS记录号WOS:000275652200033
引用统计
被引频次:69[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60582
专题北京大学第三临床医学院_超声诊断科
作者单位1.Harbin Inst Technol, State Key Lab Urban Water Resources & Environm, Sch Sci, Nanobiotechnol Div, Harbin 150080, Peoples R China
2.Peking Univ, Hosp 3, Dept Ultrasonog, Beijing 100083, Peoples R China
3.Thomas Jefferson Univ, Ultrasound Res & Educ Inst, Philadelphia, PA 19107 USA
推荐引用方式
GB/T 7714
Xing, Zhanwen,Wang, Jinrui,Ke, Hengte,et al. The fabrication of novel nanobubble ultrasound contrast agent for potential tumor imaging[J]. NANOTECHNOLOGY,2010,21(14).
APA Xing, Zhanwen.,Wang, Jinrui.,Ke, Hengte.,Zhao, Bo.,Yue, Xiuli.,...&Liu, Jibin.(2010).The fabrication of novel nanobubble ultrasound contrast agent for potential tumor imaging.NANOTECHNOLOGY,21(14).
MLA Xing, Zhanwen,et al."The fabrication of novel nanobubble ultrasound contrast agent for potential tumor imaging".NANOTECHNOLOGY 21.14(2010).
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