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学科主题: 临床医学
题名:
The fabrication of novel nanobubble ultrasound contrast agent for potential tumor imaging
作者: Xing, Zhanwen1; Wang, Jinrui2; Ke, Hengte1; Zhao, Bo2; Yue, Xiuli1; Dai, Zhifei1; Liu, Jibin3
刊名: NANOTECHNOLOGY
发表日期: 2010-04-09
DOI: 10.1088/0957-4484/21/14/145607
卷: 21, 期:14
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]: Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]: GLASS SPG MEMBRANES ; THERAPEUTIC ARTERIOGENESIS ; ACOUSTIC EMULSIFICATION ; ENHANCED PERMEABILITY ; FILLED MICROBUBBLES ; SOLID TUMORS ; WATER ; DELIVERY ; DRUG ; ECHOCARDIOGRAPHY
英文摘要:

Novel biocompatible nanobubbles were fabricated by ultrasonication of a mixture of Span 60 and polyoxyethylene 40 stearate (PEG40S) followed by differential centrifugation to isolate the relevant subpopulation from the parent suspensions. Particle sizing analysis and optical microscopy inspection indicated that the freshly generated micro/nanobubble suspension was polydisperse and the size distribution was bimodal with large amounts of nanobubbles. To develop a nano-sized contrast agent that is small enough to leak through tumor pores, a fractionation to extract smaller bubbles by variation in the time of centrifugation at 20g (relative centrifuge field, RCF) was suggested. The results showed that the population of nanobubbles with a precisely controlled mean diameter could be sorted from the initial polydisperse suspensions to meet the specified requirements. The isolated bubbles were stable over two weeks under the protection of perfluoropropane gas. The acoustic behavior of the nano-sized contrast agent was evaluated using power Doppler imaging in a normal rabbit model. An excellent power Doppler enhancement was found in vivo renal imaging after intravenous injection of the obtained nanobubbles. Given the broad spectrum of potential clinical applications, the nano-sized contrast agent may provide a versatile adjunct for ultrasonic imaging enhancement and/or treatment of tumors.

语种: 英语
所属项目编号: NSFC-30970829 ; 30672001 ; 2007AA03Z316 ; 707021 ; HIT-2008QN06
项目资助者: National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; Cultivation Fund of the Key Scientific and Technical Innovation Project ; Ministry of Education of China ; State Key Laboratory of Urban Water Resource and Environment
WOS记录号: WOS:000275652200033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60582
Appears in Collections:北京大学第三临床医学院_超声诊断科_期刊论文

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作者单位: 1.Harbin Inst Technol, State Key Lab Urban Water Resources & Environm, Sch Sci, Nanobiotechnol Div, Harbin 150080, Peoples R China
2.Peking Univ, Hosp 3, Dept Ultrasonog, Beijing 100083, Peoples R China
3.Thomas Jefferson Univ, Ultrasound Res & Educ Inst, Philadelphia, PA 19107 USA

Recommended Citation:
Xing, Zhanwen,Wang, Jinrui,Ke, Hengte,et al. The fabrication of novel nanobubble ultrasound contrast agent for potential tumor imaging[J]. NANOTECHNOLOGY,2010,21(14).
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