IR@PKUHSC  > 北京大学基础医学院  > 生物物理学系
学科主题基础医学
Influence of TRAIL gene on biomechanical properties of the human leukemic cell line Jurkat
Yao, WJ; Chen, K; Wang, XJ; Xie, LD; Wen, ZY; Yan, ZY; Chien, S
关键词TRAIL tet gene expression system Jurkat apoptosis biomechanics
刊名JOURNAL OF BIOMECHANICS
2002-12-01
35期:12页:1659-1663
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Engineering, Biomedical
研究领域[WOS]Biophysics ; Engineering
关键词[WOS]TET-ON SYSTEM ; INHIBITION ; EXPRESSION ; INDUCTION ; LIGAND
英文摘要

We cloned the cDNA fragment of human TNF-related apoptosis inducing ligand (TRAIL) into RevTet-On, a Tet-regulated and high-level gene expression system. Making use of the TRAIL gene expression system in Jurkat as a cell model, we studied the influence of TRAIL gene on the biomechanics properties of Jurkat through measuring changes of cellular biomechanics properties before and after the TRAIL gene expression, which was induced by adding tetracycline derivative doxycycline (Dox). The results indicated that the TRAIL gene expression led to significant changes in cellular biomechanics properties. The osmotic fragility increased and the cell stiffness increased after the expression of TRAIL gene. Thus, the apoptosis-inducing TRAIL gene caused significant changes in the biomechanics properties of Jurkat cells. (C) 2002 Elsevier Science Ltd. All rights reserved.

语种英语
WOS记录号WOS:000179812900015
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60583
专题北京大学基础医学院_生物物理学系
作者单位1.Peking Univ, Dept Biophys, Sch Basic Med Sci, Hemorheol Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, Beijing 100083, Peoples R China
3.Peking Univ, Dept Mech & Engn Sci, Beijing 100871, Peoples R China
4.Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
5.Univ Calif San Diego, Whitaker Inst Biomed Engn, La Jolla, CA 92093 USA
推荐引用方式
GB/T 7714
Yao, WJ,Chen, K,Wang, XJ,et al. Influence of TRAIL gene on biomechanical properties of the human leukemic cell line Jurkat[J]. JOURNAL OF BIOMECHANICS,2002,35(12):1659-1663.
APA Yao, WJ.,Chen, K.,Wang, XJ.,Xie, LD.,Wen, ZY.,...&Chien, S.(2002).Influence of TRAIL gene on biomechanical properties of the human leukemic cell line Jurkat.JOURNAL OF BIOMECHANICS,35(12),1659-1663.
MLA Yao, WJ,et al."Influence of TRAIL gene on biomechanical properties of the human leukemic cell line Jurkat".JOURNAL OF BIOMECHANICS 35.12(2002):1659-1663.
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