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Potential Health Impact on Mice after Nasal Instillation of Nano-Sized Copper Particles and Their Translocation in Mice
Liu, Yang1,4,5,6; Gao, Yuxi4,5,6; Zhang, Lili4,5,6; Wang, Tiancheng3; Wang, Jiangxue4,5,6; Jiao, Fang4,5,6; Li, Wei4,5,6; Liu, Ying4,5,6; Li, Yufeng4,5,6; Li, Bai4,5,6; Chai, Zhifang2,4,5,6; Wu, Gang1; Chen, Chunying4,5,6
关键词Copper Nanoparticles Nasal Instillation Translocation Toxicity Mice
刊名JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
2009-11-01
DOI10.1166/jnn.2009.1320
9期:11页:6335-6343
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]NERVOUS-SYSTEM ; ACUTE TOXICITY ; PULMONARY ; EXPOSURE ; BRAIN ; RAT ; IDENTIFICATION ; NANOPARTICLES ; DEPOSITION ; EPITHELIUM
英文摘要

The purpose of this study is to evaluate the overall toxicity of nasal instilled nanoscale copper particles (23.5 nm) in mice. Pathological examination, target organs identification, and blood biochemical assay of experimental mice were carried out in comparison with micro-sized copper particles (17 mu m). However, only in the high-dose group of copper nanoparticles (40 mg/kg body weight instilled for three times in one week), the body weight of mice were retarded and significant pathological changes were observed. There were hydropic degeneration around the central vein and the spotty necrosis of hepatocytes in the liver and swelling in the renal glomerulus, while, severe lesion associated with the decreased number of olfactory cells and the dilapidated laminated structure were also observed in the olfactory bulb. The serum biochemical assay also indicated the sign of renal and hepatic lesion. However, there were no obvious pathological and physiological damages in the mice after instilling different-sized copper nanoparticles with low dose of 1 mg/kg body weight. The retention and distribution of copper in various tissues show that the liver, kidneys and olfactory bulb are the main accumulated tissues for copper particles, which were determined by high sensitive element-specific technique of ICP-MS. The copper contents of the liver, kidneys and the olfactory bulb increase significantly at the group of 40 mg/kg compared to the control group, which is in agreement with the histological changes. Therefore, the data indicate that nasal inhaled copper particles at very high dosage can translocate to other organs and tissues and further induce certain lesions. The present results are helpful to get better understanding of the risk assessment and evaluation for copper nanoparticles.

语种英语
WOS记录号WOS:000270471100011
项目编号2006CB705603 ; 2006AA03Z323 ; 10475092 ; 10525524
资助机构MOST programs ; National Natural Science Foundation of China ; National Science Foundation for Distinguished Young Scholars ; Chinese Academy of Sciences
引用统计
被引频次:48[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60589
专题北京大学第三临床医学院
作者单位1.Baotou Med Coll, Dept Basic Med, Baotou 014010, Peoples R China
2.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
3.Peking Univ, Hosp 3, Dept Clin Lab Med, Beijing 100083, Peoples R China
4.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
5.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Liu, Yang,Gao, Yuxi,Zhang, Lili,et al. Potential Health Impact on Mice after Nasal Instillation of Nano-Sized Copper Particles and Their Translocation in Mice[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2009,9(11):6335-6343.
APA Liu, Yang.,Gao, Yuxi.,Zhang, Lili.,Wang, Tiancheng.,Wang, Jiangxue.,...&Chen, Chunying.(2009).Potential Health Impact on Mice after Nasal Instillation of Nano-Sized Copper Particles and Their Translocation in Mice.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,9(11),6335-6343.
MLA Liu, Yang,et al."Potential Health Impact on Mice after Nasal Instillation of Nano-Sized Copper Particles and Their Translocation in Mice".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 9.11(2009):6335-6343.
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