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学科主题: 临床医学
题名:
Potential Health Impact on Mice after Nasal Instillation of Nano-Sized Copper Particles and Their Translocation in Mice
作者: Liu, Yang1,4,5,6; Gao, Yuxi4,5,6; Zhang, Lili4,5,6; Wang, Tiancheng3; Wang, Jiangxue4,5,6; Jiao, Fang4,5,6; Li, Wei4,5,6; Liu, Ying4,5,6; Li, Yufeng4,5,6; Li, Bai4,5,6; Chai, Zhifang2,4,5,6; Wu, Gang1; Chen, Chunying4,5,6
关键词: Copper Nanoparticles ; Nasal Instillation ; Translocation ; Toxicity ; Mice
刊名: JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
发表日期: 2009-11-01
DOI: 10.1166/jnn.2009.1320
卷: 9, 期:11, 页:6335-6343
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]: NERVOUS-SYSTEM ; ACUTE TOXICITY ; PULMONARY ; EXPOSURE ; BRAIN ; RAT ; IDENTIFICATION ; NANOPARTICLES ; DEPOSITION ; EPITHELIUM
英文摘要:

The purpose of this study is to evaluate the overall toxicity of nasal instilled nanoscale copper particles (23.5 nm) in mice. Pathological examination, target organs identification, and blood biochemical assay of experimental mice were carried out in comparison with micro-sized copper particles (17 mu m). However, only in the high-dose group of copper nanoparticles (40 mg/kg body weight instilled for three times in one week), the body weight of mice were retarded and significant pathological changes were observed. There were hydropic degeneration around the central vein and the spotty necrosis of hepatocytes in the liver and swelling in the renal glomerulus, while, severe lesion associated with the decreased number of olfactory cells and the dilapidated laminated structure were also observed in the olfactory bulb. The serum biochemical assay also indicated the sign of renal and hepatic lesion. However, there were no obvious pathological and physiological damages in the mice after instilling different-sized copper nanoparticles with low dose of 1 mg/kg body weight. The retention and distribution of copper in various tissues show that the liver, kidneys and olfactory bulb are the main accumulated tissues for copper particles, which were determined by high sensitive element-specific technique of ICP-MS. The copper contents of the liver, kidneys and the olfactory bulb increase significantly at the group of 40 mg/kg compared to the control group, which is in agreement with the histological changes. Therefore, the data indicate that nasal inhaled copper particles at very high dosage can translocate to other organs and tissues and further induce certain lesions. The present results are helpful to get better understanding of the risk assessment and evaluation for copper nanoparticles.

语种: 英语
所属项目编号: 2006CB705603 ; 2006AA03Z323 ; 10475092 ; 10525524
项目资助者: MOST programs ; National Natural Science Foundation of China ; National Science Foundation for Distinguished Young Scholars ; Chinese Academy of Sciences
WOS记录号: WOS:000270471100011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60589
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Baotou Med Coll, Dept Basic Med, Baotou 014010, Peoples R China
2.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
3.Peking Univ, Hosp 3, Dept Clin Lab Med, Beijing 100083, Peoples R China
4.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
5.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China

Recommended Citation:
Liu, Yang,Gao, Yuxi,Zhang, Lili,et al. Potential Health Impact on Mice after Nasal Instillation of Nano-Sized Copper Particles and Their Translocation in Mice[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2009,9(11):6335-6343.
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