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学科主题基础医学
Over-Expression of Heat Shock Protein 70 in Mice Is Associated with Growth Retardation, Tumor Formation, and Early Death
Vanhooren, Valerie1,2; Liu, Xue-En1,2,5; Desmyter, Liesbeth1,2; Fan, Ye-Dong3; Vanwalleghem, Lieve4; Van Molle, Wim1,2; Dewaele, Sylviane1,2; Praet, Marleen4; Contreras, Roland1,2; Libert, Claude1,2; Chen, Cuiying1,2
刊名REJUVENATION RESEARCH
2008-12-01
DOI10.1089/rej.2008.0783
11期:6页:1013-1020
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Geriatrics & Gerontology
研究领域[WOS]Geriatrics & Gerontology
关键词[WOS]HEAT-SHOCK-PROTEIN ; GLUCOCORTICOID-RECEPTOR ; INHIBITS APOPTOSIS ; DROSOPHILA-MELANOGASTER ; CEREBRAL-ISCHEMIA ; APAF-1 APOPTOSOME ; TRANSGENIC MICE ; NECROSIS-FACTOR ; LUNG-CANCER ; FACTOR-I
英文摘要

Experiments in lower organisms, such as worms and flies, indicate that the molecular chaperone protein heat shock protein 70 (HSP70) is a longevity factor. In contrast, we demonstrate here that mice overexpressing HSP70 display growth retardation and early death. HSP70 transgenic mice displayed increased levels of serum corticosterone and weaker expression and activity of the glucocorticoid receptor in the liver. Serum insulin-like growth factor-1 (IGF-1) concentrations in the transgenic mice were 50% lower than in the control mice, leading to growth retardation. HSP70 transgenic mice showed decreased expression of Casp9, which encodes caspase-9, and increased expression of the anti-apoptotic Bcl-2 gene, indicating that apoptosis is suppressed. Consequently, most of the transgenic animals died before the age of 18 months from tumors in their lungs and lymph nodes. We suggest that the proinflammatory and antiapoptotic effects of HSP70 might be responsible for the growth retardation, tumor formation, mid early death observed in the HSP70 transgenic mice.

语种英语
WOS记录号WOS:000262886400004
资助机构Research Foundation Flanders (FWO Vlaanderen) ; Belgian Science Policy
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
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条目标识符http://ir.bjmu.edu.cn/handle/400002259/60590
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
作者单位1.VIB, Dept Mol Biomed Res, B-9052 Ghent, Belgium
2.Univ Ghent, Dept Mol Biol, B-9000 Ghent, Belgium
3.Ghent Univ Hosp, Dept Surg, B-9000 Ghent, Belgium
4.Ghent Univ Hosp, Dept Pathol, B-9000 Ghent, Belgium
5.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100871, Peoples R China
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GB/T 7714
Vanhooren, Valerie,Liu, Xue-En,Desmyter, Liesbeth,et al. Over-Expression of Heat Shock Protein 70 in Mice Is Associated with Growth Retardation, Tumor Formation, and Early Death[J]. REJUVENATION RESEARCH,2008,11(6):1013-1020.
APA Vanhooren, Valerie.,Liu, Xue-En.,Desmyter, Liesbeth.,Fan, Ye-Dong.,Vanwalleghem, Lieve.,...&Chen, Cuiying.(2008).Over-Expression of Heat Shock Protein 70 in Mice Is Associated with Growth Retardation, Tumor Formation, and Early Death.REJUVENATION RESEARCH,11(6),1013-1020.
MLA Vanhooren, Valerie,et al."Over-Expression of Heat Shock Protein 70 in Mice Is Associated with Growth Retardation, Tumor Formation, and Early Death".REJUVENATION RESEARCH 11.6(2008):1013-1020.
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