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Synthesis of an antimetastatic tetrasaccharide beta-D-Gal-(1 -> 4)-beta-D-GlcpNAc-(1 -> 6)-alpha-D-Manp-(1 -> 6)-beta-D-Manp-OMe
Liao, Kai Jun; Jin, Xiao Feng; Meng, Xiang Bao; Li, Chen; Li, Zhong Jun
关键词Antimetastatic tetrasaccharide Thioglycoside Koenigs-Knorr method Azidoiodo-glycosylation 2-Iodo-2-deoxyl-actosyl azide beta-Methyl mannoside
刊名CHINESE CHEMICAL LETTERS
2012-12-01
DOI10.1016/j.cclet.2012.10.022
23期:12页:1371-1374
收录类别SCI ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
资助者National Basic Research Program of China (973 program) ; National Natural Science Foundation of China ; National Basic Research Program of China (973 program) ; National Natural Science Foundation of China
研究领域[WOS]Chemistry
关键词[WOS]GLYCOSIDE SYNTHESIS ; LAMININ ; DONORS ; INTEGRIN
英文摘要

An antimetastatic tetrasaccharide T-1, beta-D-Gal-(1 -> 4)-beta-D-GlcpNAc-(1 -> 6)-alpha-D-Manp-(1 -> 6)-beta-D-Manp-OMe, was synthesized with two approaches. The first approach was a conventional method employing thioglycoside and Koenigs-Knorr glycosylation reaction in 24% overall yield. The second one was a novel route through the azidoiodo-glycosylation strategy by using 2-iodo-2-deoxylactosyl azide as the donor in 36% overall yield. (C) 2012 Zhong Jun Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

语种英语
所属项目编号2012CB822100 ; 20972012
资助者National Basic Research Program of China (973 program) ; National Natural Science Foundation of China ; National Basic Research Program of China (973 program) ; National Natural Science Foundation of China
WOS记录号WOS:000313999900015
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60591
专题北京大学药学院
作者单位Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Liao, Kai Jun,Jin, Xiao Feng,Meng, Xiang Bao,et al. Synthesis of an antimetastatic tetrasaccharide beta-D-Gal-(1 -> 4)-beta-D-GlcpNAc-(1 -> 6)-alpha-D-Manp-(1 -> 6)-beta-D-Manp-OMe[J]. CHINESE CHEMICAL LETTERS,2012,23(12):1371-1374.
APA Liao, Kai Jun,Jin, Xiao Feng,Meng, Xiang Bao,Li, Chen,&Li, Zhong Jun.(2012).Synthesis of an antimetastatic tetrasaccharide beta-D-Gal-(1 -> 4)-beta-D-GlcpNAc-(1 -> 6)-alpha-D-Manp-(1 -> 6)-beta-D-Manp-OMe.CHINESE CHEMICAL LETTERS,23(12),1371-1374.
MLA Liao, Kai Jun,et al."Synthesis of an antimetastatic tetrasaccharide beta-D-Gal-(1 -> 4)-beta-D-GlcpNAc-(1 -> 6)-alpha-D-Manp-(1 -> 6)-beta-D-Manp-OMe".CHINESE CHEMICAL LETTERS 23.12(2012):1371-1374.
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