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学科主题: 药学
题名:
Synthesis of an antimetastatic tetrasaccharide beta-D-Gal-(1 -> 4)-beta-D-GlcpNAc-(1 -> 6)-alpha-D-Manp-(1 -> 6)-beta-D-Manp-OMe
作者: Liao, Kai Jun; Jin, Xiao Feng; Meng, Xiang Bao; Li, Chen; Li, Zhong Jun
关键词: Antimetastatic tetrasaccharide ; Thioglycoside ; Koenigs-Knorr method ; Azidoiodo-glycosylation ; 2-Iodo-2-deoxyl-actosyl azide ; beta-Methyl mannoside
刊名: CHINESE CHEMICAL LETTERS
发表日期: 2012-12-01
DOI: 10.1016/j.cclet.2012.10.022
卷: 23, 期:12, 页:1371-1374
收录类别: SCI ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: GLYCOSIDE SYNTHESIS ; LAMININ ; DONORS ; INTEGRIN
英文摘要:

An antimetastatic tetrasaccharide T-1, beta-D-Gal-(1 -> 4)-beta-D-GlcpNAc-(1 -> 6)-alpha-D-Manp-(1 -> 6)-beta-D-Manp-OMe, was synthesized with two approaches. The first approach was a conventional method employing thioglycoside and Koenigs-Knorr glycosylation reaction in 24% overall yield. The second one was a novel route through the azidoiodo-glycosylation strategy by using 2-iodo-2-deoxylactosyl azide as the donor in 36% overall yield. (C) 2012 Zhong Jun Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

语种: 英语
所属项目编号: 2012CB822100 ; 20972012
项目资助者: National Basic Research Program of China (973 program) ; National Natural Science Foundation of China
WOS记录号: WOS:000313999900015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60591
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Liao, Kai Jun,Jin, Xiao Feng,Meng, Xiang Bao,et al. Synthesis of an antimetastatic tetrasaccharide beta-D-Gal-(1 -> 4)-beta-D-GlcpNAc-(1 -> 6)-alpha-D-Manp-(1 -> 6)-beta-D-Manp-OMe[J]. CHINESE CHEMICAL LETTERS,2012,23(12):1371-1374.
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