IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Tripterygium Preparations for the Treatment of CKD: A Systematic Review and Meta-analysis
Zhu, Bin1,2; Wang, Ying1; Jardine, Meg1; Jun, Min1; Lv, Ji-Cheng1,3; Cass, Alan1; Liyanage, Thaminda1; Chen, Hong-Yu2; Wang, Yong-jun2; Perkovic, Vlado1
关键词Tripterygium traditional Chinese medicine Chinese herbs chronic kidney disease systematic review meta-analysis proteinuria kidney function glomerular disease
刊名AMERICAN JOURNAL OF KIDNEY DISEASES
2013-09-01
DOI10.1053/j.ajkd.2013.02.374
62期:3页:515-530
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]UNILATERAL URETERAL OBSTRUCTION ; CHINESE HERBAL MEDICINE ; CHRONIC KIDNEY-DISEASE ; WILFORDII HOOK-F ; NF-KAPPA-B ; CLINICAL-TRIALS ; TRIPTOLIDE ; CELLS ; RATS ; MULTIGLYCOSIDE
英文摘要

Background: Preparations of the herb Tripterygium wilfordii Hook F are used widely for the treatment of chronic kidney disease in China. The efficacy and safety of Tripterygium preparations still have not been fully identified.

Study Design: Systematic review and meta-analysis.

Setting & Population: Patients with chronic kidney disease.

Selection Criteria for Studies: Randomized controlled trials.

Intervention: Tripterygium preparations (Tripterygium glycoside tablets, Tripterygium hypoglaucum Hutch tablets, and Tripterygium granules or extracts) versus placebo, standard care, or other immunosuppressive treatment.

Outcomes: Weighted mean difference and summary estimates of relative risk (RR) reductions with 95% CIs were calculated with a random-effects model. Outcomes analyzed included change in proteinuria, serum creatinine level, and creatinine clearance rate, as well as remission and relapse rate and drug-related adverse events.

Results: We identified 75 trials that included 4,386 participants. Overall, Tripterygium therapy reduced proteinuria by protein excretion of 628 (95% CI, -736 to -521) mg/d and reduced serum creatinine level by 0.12 (95% CI, -0.17 to -0.06) mg/dL compared with controls (both P < 0.001) in a range of kidney conditions. Tripterygium preparations also increased the rate of complete remission by 56% (95% CI, 32%-85%; P < 0.001) and of complete or partial remission by 24% (95% CI, 17%-31%; P < 0.001) while reducing relapse by 58% (95% CI, 42%-69%; P < 0.001). Tripterygium preparations increased the rate of liver function test result abnormalities (RR, 4.03; 95% CI, 2.24-7.25; P < 0.001) and altered menstruation (RR, 5.29; 95% CI, 2.09-13.38; P < 0.001).

Limitations: Suboptimal study quality, significant heterogeneity in the primary outcome.

Conclusions: Tripterygium preparations may have nephroprotective effects, but high-quality trials are required to reliably determine the balance of benefits and harms. (C) 2013 by the National Kidney Foundation, Inc.

语种英语
WOS记录号WOS:000324023700013
资助机构International Society of Nephrology ; Asian Pacific Society of Nephrology ; CREED ; National Health and Medical Research Council ; Royal Australasian College of Physicians ; Australasian Kidney Trials Network ; Heart Foundation
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60595
专题北京大学第一临床医学院_肾脏内科
作者单位1.Univ Sydney, George Inst Global Hlth, Sydney, NSW 2006, Australia
2.Hangzhou Hosp Tradit Chinese Med, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China
3.Peking Univ First Hosp, Div Nephrol, Peking Univ Inst Nephrol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhu, Bin,Wang, Ying,Jardine, Meg,et al. Tripterygium Preparations for the Treatment of CKD: A Systematic Review and Meta-analysis[J]. AMERICAN JOURNAL OF KIDNEY DISEASES,2013,62(3):515-530.
APA Zhu, Bin.,Wang, Ying.,Jardine, Meg.,Jun, Min.,Lv, Ji-Cheng.,...&Perkovic, Vlado.(2013).Tripterygium Preparations for the Treatment of CKD: A Systematic Review and Meta-analysis.AMERICAN JOURNAL OF KIDNEY DISEASES,62(3),515-530.
MLA Zhu, Bin,et al."Tripterygium Preparations for the Treatment of CKD: A Systematic Review and Meta-analysis".AMERICAN JOURNAL OF KIDNEY DISEASES 62.3(2013):515-530.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhu, Bin]的文章
[Wang, Ying]的文章
[Jardine, Meg]的文章
百度学术
百度学术中相似的文章
[Zhu, Bin]的文章
[Wang, Ying]的文章
[Jardine, Meg]的文章
必应学术
必应学术中相似的文章
[Zhu, Bin]的文章
[Wang, Ying]的文章
[Jardine, Meg]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。