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学科主题: 药学
题名:
Biotransformation of myrislignan by rat liver microsomes in vitro
作者: Li, Fei; Yang, Xiu-Wei1
关键词: Myristica fragrans ; Myristiceae ; biotransformation ; neolignan ; myrislignan ; erythro-(1R,2S)-2-(4-allyl-2,6-dimethoxyphenoxyl)-1-(4-hydroxyl-3-methoxyphenyl) propan-1-ol ; myrislignanometins A-G
刊名: PHYTOCHEMISTRY
发表日期: 2008-02-01
DOI: 10.1016/j.phytochem.2007.09.008
卷: 69, 期:3, 页:765-771
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]: MYRISTICA-FRAGRANS ; NUTMEG INTOXICATION ; MODEL COMPOUNDS ; CONSTITUENTS ; LIGNIN ; MACE ; ARIL ; HEPATOCYTES ; ELEMICIN
英文摘要:

Myrislignan (1), erythro-(1R,2S)-2-(4-allyl-2,6-dimethoxyphenoxyl)-1-(4-hydroxy-3-methoxyphenyl) propan-1-ol, is a major acyclic neolignan in seeds of Myristica fragrans. Studies have suggested that myrislignan may deter feeding activity, but little is known about its metabolism. We investigated the biotransformation of myrislignan by rat liver microsomes in vitro. Seven metabolites were produced by liver microsomes from rats pre-treated with sodium phenobarbital. These were identified, using spectroscopic methods, as myrislignanometins A-G (2-8), respectively. (c) 2007 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000254310400020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60605
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China

Recommended Citation:
Li, Fei,Yang, Xiu-Wei. Biotransformation of myrislignan by rat liver microsomes in vitro[J]. PHYTOCHEMISTRY,2008,69(3):765-771.
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