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Biotransformation of myrislignan by rat liver microsomes in vitro
Li, Fei; Yang, Xiu-Wei1
关键词Myristica fragrans Myristiceae biotransformation neolignan myrislignan erythro-(1R,2S)-2-(4-allyl-2,6-dimethoxyphenoxyl)-1-(4-hydroxyl-3-methoxyphenyl) propan-1-ol myrislignanometins A-G
刊名PHYTOCHEMISTRY
2008-02-01
DOI10.1016/j.phytochem.2007.09.008
69期:3页:765-771
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]MYRISTICA-FRAGRANS ; NUTMEG INTOXICATION ; MODEL COMPOUNDS ; CONSTITUENTS ; LIGNIN ; MACE ; ARIL ; HEPATOCYTES ; ELEMICIN
英文摘要

Myrislignan (1), erythro-(1R,2S)-2-(4-allyl-2,6-dimethoxyphenoxyl)-1-(4-hydroxy-3-methoxyphenyl) propan-1-ol, is a major acyclic neolignan in seeds of Myristica fragrans. Studies have suggested that myrislignan may deter feeding activity, but little is known about its metabolism. We investigated the biotransformation of myrislignan by rat liver microsomes in vitro. Seven metabolites were produced by liver microsomes from rats pre-treated with sodium phenobarbital. These were identified, using spectroscopic methods, as myrislignanometins A-G (2-8), respectively. (c) 2007 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000254310400020
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60605
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China
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GB/T 7714
Li, Fei,Yang, Xiu-Wei. Biotransformation of myrislignan by rat liver microsomes in vitro[J]. PHYTOCHEMISTRY,2008,69(3):765-771.
APA Li, Fei,&Yang, Xiu-Wei.(2008).Biotransformation of myrislignan by rat liver microsomes in vitro.PHYTOCHEMISTRY,69(3),765-771.
MLA Li, Fei,et al."Biotransformation of myrislignan by rat liver microsomes in vitro".PHYTOCHEMISTRY 69.3(2008):765-771.
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