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Glycogen synthase kinase 3 beta in the nucleus accumbens core mediates cocaine-induced behavioral sensitization
Xu, Chun-mei; Wang, Jun; Wu, Ping; Zhu, Wei-li; Li, Qian-qian; Xue, Yan-xue; Zhai, Hai-fen; Shi, Jie; Lu, Lin
关键词cocaine glycogen synthase kinase 3 beta locomotor activity nucleus accumbens sensitization
刊名JOURNAL OF NEUROCHEMISTRY
2009-12-01
DOI10.1111/j.1471-4159.2009.06414.x
111期:6页:1357-1368
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]LONG-TERM POTENTIATION ; DOPAMINERGIC NEUROTRANSMISSION ; SYNAPTIC PLASTICITY ; LOCOMOTOR-ACTIVITY ; SIGNALING PATHWAY ; DENDRITIC SPINES ; TRANSGENIC MICE ; DRUG-ADDICTION ; PROTEIN-KINASE ; LITHIUM
英文摘要

Glycogen synthase kinase 3 beta (GSK-3 beta) is a ubiquitous serine/threonine protein kinase involved in a number of signaling pathways. Previous studies have demonstrated a role for GSK-3 beta in the synaptic plasticity underlying dopamine-associated behaviors and diseases. Drug sensitization is produced by repeated exposure to the drug and is thought to reflect neuroadaptations that contribute to addiction. However, the role of GSK-3 beta in cocaine-induced behavior sensitization has not been examined. The present study investigated the effects of chronic cocaine exposure on GSK-3 beta activity in the nucleus accumbens (NAc) and determined whether changes in GSK-3 beta activity in the NAc are associated with cocaine-induced locomotor sensitization. We also explored whether blockade of GSK-3 beta activity in the NAc inhibits the initiation and expression of cocaine-induced locomotor sensitization in rats using systemic or brain region-specific administration of the GSK-3 beta inhibitors lithium chloride (LiCl) and SB216763. GSK-3 beta activity in the NAc core, but not NAc shell, increased after chronic cocaine (10 mg/kg, i.p.) administration. The initiation and expression of cocaine-induced locomotor sensitization was attenuated by systemic administration of LiCl (100 mg/kg, i.p.) or direct infusion of SB216763 (1 ng/side) into the NAc core, but not NAc shell. Collectively, these results indicate that GSK-3 beta activity in the NAc core, but not NAc shell, mediates the initiation and expression of cocaine-induced locomotor sensitization, suggesting that GSK-3 beta may be a potential target for the treatment of cocaine addiction.

语种英语
WOS记录号WOS:000272130300005
项目编号2007CB512302 ; 2009CB522004 ; 30670713 ; 30725016
资助机构National Basic Research Program of China ; Natural Science Foundation of China
引用统计
被引频次:51[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60607
专题北京大学医学部管理机构_医学部
中国药物依赖性研究所
作者单位Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Xu, Chun-mei,Wang, Jun,Wu, Ping,et al. Glycogen synthase kinase 3 beta in the nucleus accumbens core mediates cocaine-induced behavioral sensitization[J]. JOURNAL OF NEUROCHEMISTRY,2009,111(6):1357-1368.
APA Xu, Chun-mei.,Wang, Jun.,Wu, Ping.,Zhu, Wei-li.,Li, Qian-qian.,...&Lu, Lin.(2009).Glycogen synthase kinase 3 beta in the nucleus accumbens core mediates cocaine-induced behavioral sensitization.JOURNAL OF NEUROCHEMISTRY,111(6),1357-1368.
MLA Xu, Chun-mei,et al."Glycogen synthase kinase 3 beta in the nucleus accumbens core mediates cocaine-induced behavioral sensitization".JOURNAL OF NEUROCHEMISTRY 111.6(2009):1357-1368.
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