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Death-associated protein-3, DAP-3, correlates with preoperative chemotherapy effectiveness and prognosis of gastric cancer patients following perioperative chemotherapy and radical gastrectomy
Jia, Y.1,2,3; Ye, L.1,2; Ji, K.1,2; Zhang, L.1,3; Hargest, R.1,2; Ji, J.1,3; Jiang, W. G.1,2
关键词gastric cancer neoadjuvant chemotherapy apoptosis DAP3 effectiveness
刊名BRITISH JOURNAL OF CANCER
2014-01-21
DOI10.1038/bjc.2013.712
110期:2页:421-429
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者Cancer Research Wales ; Albert Hung Foundation ; Cardiff University&prime ; s China Medical Scholarship ; Cancer Research Wales ; Albert Hung Foundation ; Cardiff University&prime ; s China Medical Scholarship
研究领域[WOS]Oncology
关键词[WOS]MITOCHONDRIAL RIBOSOMAL-PROTEINS ; CELL-DEATH ; PROMOTER HYPERMETHYLATION ; INDUCED APOPTOSIS ; BREAST-CANCER ; SURVIVAL ; MEDIATOR ; IDENTIFICATION ; METASTASIS ; EXPRESSION
英文摘要

Background: DAP3 is a member of the death-associated protein (DAP) family and is characterised by proapoptotic function. It is involved in both exogenous and endogenous apoptotic pathways. In our previous studies, apoptotic level was found to be correlated with the effectiveness of preoperative chemotherapy. The effectiveness of preoperative chemotherapy was also associated with the overall effectiveness of the combined therapy and prognosis. The present study aimed to investigate the role of DAP3 in the evaluation of preoperative chemotherapy effectiveness and its ability to predict prognosis in gastric cancer.

Methods: Quantitative PCR and immunohistochemistry staining were performed in 87 patients who received combined therapy. Knockdown of DAP3 was conducted in gastric cancer cell lines to investigate its impact on cell growth, migration, adhesion and invasion. Tolerance to chemotherapy agents was determined by assessing apoptosis and caspase-3.

Results: Higher DAP3 expression in gastric tumours was correlated with better prognosis. Knockdown of DAP3 expression promoted cell migration and enhanced resistance to chemotherapy by inhibiting apoptosis.

Conclusion: DAP3 is a potential molecular marker for response to preoperative chemotherapy and for predicting prognosis in gastric cancer patients treated with neoadjuvant chemotherapy and gastrectomy.

语种英语
资助者Cancer Research Wales ; Albert Hung Foundation ; Cardiff University&prime ; s China Medical Scholarship ; Cancer Research Wales ; Albert Hung Foundation ; Cardiff University&prime ; s China Medical Scholarship
WOS记录号WOS:000330354700019
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60611
专题北京大学临床肿瘤学院_胃肠肿瘤中心
作者单位1.Cardiff Univ, Sch Med, Cardiff Univ Peking Univ Sch Oncol Joint Inst, Cardiff CF14 4XN, S Glam, Wales
2.Cardiff Univ, Sch Med, Metastasis & Angiogenesis Res Grp, Cardiff CF14 4XN, S Glam, Wales
3.Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Surg, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
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Jia, Y.,Ye, L.,Ji, K.,et al. Death-associated protein-3, DAP-3, correlates with preoperative chemotherapy effectiveness and prognosis of gastric cancer patients following perioperative chemotherapy and radical gastrectomy[J]. BRITISH JOURNAL OF CANCER,2014,110(2):421-429.
APA Jia, Y..,Ye, L..,Ji, K..,Zhang, L..,Hargest, R..,...&Jiang, W. G..(2014).Death-associated protein-3, DAP-3, correlates with preoperative chemotherapy effectiveness and prognosis of gastric cancer patients following perioperative chemotherapy and radical gastrectomy.BRITISH JOURNAL OF CANCER,110(2),421-429.
MLA Jia, Y.,et al."Death-associated protein-3, DAP-3, correlates with preoperative chemotherapy effectiveness and prognosis of gastric cancer patients following perioperative chemotherapy and radical gastrectomy".BRITISH JOURNAL OF CANCER 110.2(2014):421-429.
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