IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
In vitro and in vivo studies on nanocrystalline Ti fabricated by equal channel angular pressing with microcrystalline CP Ti as control
Nie, F. L.1,2,3; Zheng, Y. F.1,2,4; Wei, S. C.4,5; Wang, D. S.6; Yu, Z. T.7; Salimgareeva, G. K.8; Polyakov, A. V.8; Valiev, R. Z.8
关键词bulk nanocrystalline Ti equal channel angular pressing bioactivity bone growing remodeling
刊名JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
2013-06-01
DOI10.1002/jbm.a.34472
101期:6页:1694-1707
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
资助者National Basic Research Program of China (973 Program) ; National High Technology Research and Development Program of China (863 Program) ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; National High Technology Research and Development Program of China (863 Program) ; National Natural Science Foundation of China
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]SEVERE PLASTIC-DEFORMATION ; HIGH-PRESSURE TORSION ; NANOSTRUCTURED TITANIUM ; RODS ; STRATEGIES ; ADHESION ; METALS
英文摘要

Bulk nanocrystalline Ti bars (Grade 4, phi 4 x 3000 mm3) were massively fabricated by equal channel angular pressing (ECAP) via follow-up conform scheme with the microcrystalline CP Ti as raw material. Homogeneous nanostructured crystals with the average grain size of 250 nm were identified for the ECAPed Ti, with extremely high tensile/fatigue strength (around 1240/620 MPa) and adorable elongation (more than 5%). Pronounced formation of bonelike apatite for the nanocrystalline Ti group after 14 days static immersion in simulated body fluids (SBF) reveals the prospective in vitro bioactive capability of fast calcification, whereas an estimated 17% increment in protein adsorption represents good bioaffinity of nanocrystalline Ti. The documentation onto the whole life circle of osteoblast cell lines (MG63) revealed the strong interactions and superior cellular functionalization when they are co-incubated with bulk nanocrystalline Ti sample. Moreover, thread-structured specimens were designed and implanted into the tibia of Beagles dogs till 12 weeks to study the in vivo responses between bone and metallic implant made of bulk nanocrystalline Ti, with the microcrystalline Ti as control. For the implanted nanostructured Ti group, neoformed bone around the implants underwent the whole-stage transformation proceeding from originally osteons or immature woven bone to mature lamellar bone (skeletonic trabecular), even with the remodeling being finished till 12 weeks. The phenomenal osseointegration of direct implant-bone contact can be revealed from the group of the ECAPed Ti without fibrous tissue encapsulation in the gap between the implant and autogenous bone. (c) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

语种英语
所属项目编号2007CB936103 ; 2012CB619102 ; 2011AA030101 ; 2011AA030103 ; 31170909
资助者National Basic Research Program of China (973 Program) ; National High Technology Research and Development Program of China (863 Program) ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; National High Technology Research and Development Program of China (863 Program) ; National Natural Science Foundation of China
WOS记录号WOS:000317864000017
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60613
Collection北京大学口腔医学院
作者单位1.SFDA, Ctr Med Device Evaluat, Beijing 100044, Peoples R China
2.Peking Univ, State Key Lab Turbulence & Complex Syst, Coll Engn, Beijing 100871, Peoples R China
3.Peking Univ, Dept Mat Sci & Engn, Coll Engn, Beijing 100871, Peoples R China
4.Peking Univ, Ctr Biomed Mat & Tissue Engn, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
5.Peking Univ, Sch Stomatol, Ctr Biomat & Med Devices, Beijing 100081, Peoples R China
6.Chinese Peoples Liberat Army Gen Hosp, Inst Stomatol, Beijing 100853, Peoples R China
7.Northwest Inst Nonferrous Met Res, Biomat Res Ctr, Xian 710016, Peoples R China
8.Ufa State Aviat Tech Univ, Inst Phys Adv Mat, Ufa, Russia
Recommended Citation
GB/T 7714
Nie, F. L.,Zheng, Y. F.,Wei, S. C.,et al. In vitro and in vivo studies on nanocrystalline Ti fabricated by equal channel angular pressing with microcrystalline CP Ti as control[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2013,101(6):1694-1707.
APA Nie, F. L..,Zheng, Y. F..,Wei, S. C..,Wang, D. S..,Yu, Z. T..,...&Valiev, R. Z..(2013).In vitro and in vivo studies on nanocrystalline Ti fabricated by equal channel angular pressing with microcrystalline CP Ti as control.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,101(6),1694-1707.
MLA Nie, F. L.,et al."In vitro and in vivo studies on nanocrystalline Ti fabricated by equal channel angular pressing with microcrystalline CP Ti as control".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 101.6(2013):1694-1707.
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