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学科主题: 临床医学
题名:
The role of poly(ADP-ribosyl)ation in DNA damage response and cancer chemotherapy
作者: Li, M.1,2; Yu, X.2
刊名: ONCOGENE
发表日期: 2015-06-01
DOI: 10.1038/onc.2014.295
卷: 34, 期:26, 页:3349-3356
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
关键词[WOS]: STRAND BREAK REPAIR ; NUCLEOTIDE EXCISION-REPAIR ; SEVERE COMBINED IMMUNODEFICIENCY ; ADENOSINE-DIPHOSPHATE RIBOSE ; PROTEIN-PROTEIN INTERACTIONS ; HISTONE ADP-RIBOSYLATION ; HOMOLOGY-DIRECTED REPAIR ; DOMAIN BARD1 GENE ; MAMMALIAN-CELLS ; RING DOMAIN
英文摘要:

DNA damage is a deleterious threat, but occurs daily in all types of cells. In response to DNA damage, poly(ADP-ribosyl)ation, a unique post-translational modification, is immediately catalyzed by poly(ADP-ribose) polymerases (PARPs) at DNA lesions, which facilitates DNA damage repair. Recent studies suggest that poly(ADP-ribosyl) ation is one of the first steps of cellular DNA damage response and governs early DNA damage response pathways. Suppression of DNA damage-induced poly(ADP-ribosyl) ation by PARP inhibitors impairs early DNA damage response events. Moreover, PARP inhibitors are emerging as anti-cancer drugs in phase III clinical trials for BRCA-deficient tumors. In this review, we discuss recent findings on poly(ADP-ribosyl) ation in DNA damage response as well as the molecular mechanism by which PARP inhibitors selectively kill tumor cells with BRCA mutations.

语种: 英语
所属项目编号: CA132755 ; CA130899
项目资助者: National Institute of Health ; Department of Defense ; Ovarian Cancer Research Foundation
WOS记录号: WOS:000356871700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60614
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Reprod Med Ctr, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
2.Univ Michigan, Sch Med, Dept Internal Med, Div Mol Med & Genet, Ann Arbor, MI 48109 USA

Recommended Citation:
Li, M.,Yu, X.. The role of poly(ADP-ribosyl)ation in DNA damage response and cancer chemotherapy[J]. ONCOGENE,2015,34(26):3349-3356.
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