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Robo1/Robo4: Different expression patterns in retinal development
Huang, Lvzhen1; Yu, Wenzhen1; Li, Xiaoxin1; Niu, Lanjun1; Li, Kai2; Li, Juan2
关键词retina Robo development angiogenesis
刊名EXPERIMENTAL EYE RESEARCH
2009-03-01
DOI10.1016/j.exer.2008.11.016
88期:3页:583-588
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]AXON GUIDANCE ; MAGIC ROUNDABOUT ; ANGIOGENESIS ; GROWTH ; INHIBITION ; ZEBRAFISH ; MIGRATION ; RECEPTORS ; SUGGEST ; MIDLINE
英文摘要

Two members of the roundabout (Robo) family, Robot and Robo4, serve as neuronal guidance receptors. During neurogenesis, Robot and Robo4 participate in axonal guidance by mediating a repulsive signal. It has been reported that Robo4 is mainly expressed in the vasculature and that Robo1 is expressed both in neural and non-neural tissues. However, the roles of these Robo proteins in the mammalian vasculature are still unclear. In this current study, the expression patterns of Robot and Robo4 in the retinal vasculature were determined using C57BL/6J mice at postnatal days (P) 1, P3, P5, P7, P9, P12, P14, P17, P21 and adult mice (1 month). We found that Robo4 was expressed not only in the retinal vessels but also in the retinal ganglion cell and photoreceptor layers during retinal development. Robo4 expression peaked at P3 and P9, which suggest that Robo4 may function in stabilizing the retinal vasculature. Robo1 expression was observed in the retina neuronal cells and vessels. Both Robot mRNA and protein expression showed a typical expression pattern, which related to Robo1′s roles in the different stages of retinal vascular development in the murine retina. Robo1 displayed high expression levels at PI (correlated with superficial vascular plexus formation) and P7 (correlated with deep vascular plexus formation). The high levels of Robo1 during these two well-defined phases of retinal capillary plexus formation indicate that Robo1 is likely to play a part in retinal neovascularization. (C) 2008 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000264783900031
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被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60620
专题北京大学第二临床医学院_眼科
作者单位1.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100044, Peoples R China
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Huang, Lvzhen,Yu, Wenzhen,Li, Xiaoxin,et al. Robo1/Robo4: Different expression patterns in retinal development[J]. EXPERIMENTAL EYE RESEARCH,2009,88(3):583-588.
APA Huang, Lvzhen,Yu, Wenzhen,Li, Xiaoxin,Niu, Lanjun,Li, Kai,&Li, Juan.(2009).Robo1/Robo4: Different expression patterns in retinal development.EXPERIMENTAL EYE RESEARCH,88(3),583-588.
MLA Huang, Lvzhen,et al."Robo1/Robo4: Different expression patterns in retinal development".EXPERIMENTAL EYE RESEARCH 88.3(2009):583-588.
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