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学科主题: 临床医学
题名:
Robo1/Robo4: Different expression patterns in retinal development
作者: Huang, Lvzhen1; Yu, Wenzhen1; Li, Xiaoxin1; Niu, Lanjun1; Li, Kai2; Li, Juan2
关键词: retina ; Robo ; development ; angiogenesis
刊名: EXPERIMENTAL EYE RESEARCH
发表日期: 2009-03-01
DOI: 10.1016/j.exer.2008.11.016
卷: 88, 期:3, 页:583-588
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: AXON GUIDANCE ; MAGIC ROUNDABOUT ; ANGIOGENESIS ; GROWTH ; INHIBITION ; ZEBRAFISH ; MIGRATION ; RECEPTORS ; SUGGEST ; MIDLINE
英文摘要:

Two members of the roundabout (Robo) family, Robot and Robo4, serve as neuronal guidance receptors. During neurogenesis, Robot and Robo4 participate in axonal guidance by mediating a repulsive signal. It has been reported that Robo4 is mainly expressed in the vasculature and that Robo1 is expressed both in neural and non-neural tissues. However, the roles of these Robo proteins in the mammalian vasculature are still unclear. In this current study, the expression patterns of Robot and Robo4 in the retinal vasculature were determined using C57BL/6J mice at postnatal days (P) 1, P3, P5, P7, P9, P12, P14, P17, P21 and adult mice (1 month). We found that Robo4 was expressed not only in the retinal vessels but also in the retinal ganglion cell and photoreceptor layers during retinal development. Robo4 expression peaked at P3 and P9, which suggest that Robo4 may function in stabilizing the retinal vasculature. Robo1 expression was observed in the retina neuronal cells and vessels. Both Robot mRNA and protein expression showed a typical expression pattern, which related to Robo1′s roles in the different stages of retinal vascular development in the murine retina. Robo1 displayed high expression levels at PI (correlated with superficial vascular plexus formation) and P7 (correlated with deep vascular plexus formation). The high levels of Robo1 during these two well-defined phases of retinal capillary plexus formation indicate that Robo1 is likely to play a part in retinal neovascularization. (C) 2008 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000264783900031
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60620
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100044, Peoples R China

Recommended Citation:
Huang, Lvzhen,Yu, Wenzhen,Li, Xiaoxin,et al. Robo1/Robo4: Different expression patterns in retinal development[J]. EXPERIMENTAL EYE RESEARCH,2009,88(3):583-588.
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