IR@PKUHSC  > 北京大学第一临床医学院  > 泌尿外科
学科主题临床医学
Functional interaction of TCF4 with ATF5 to regulate the Wnt signaling pathway
Ye, XJ; Zhang, ZW; Zhang, XJ; Lin, GT; Xiong, SQ; Jin, GH; Han, L; Huang, SS; Chen, PL; Al, JK; Xin, DQ; Guo, YL; Chang, ZJ
关键词TCF4 ATF5 protein-protein interaction Wnt signaling pathway gene regulation
刊名CHINESE SCIENCE BULLETIN
2003-04-01
48期:7页:668-672
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ELEMENT-BINDING-PROTEIN ; TRANSCRIPTION FACTORS ; EXPRESSION ; BIOLOGY ; CANCER ; CREB
英文摘要

Wnt signaling directs cell-fate choices during embryonic development and tissue tumorigenesis. T cell factor 4 (TCF4) plays a pivotal role in the Wnt signaling pathway. We demonstrate that a specific protein-protein interaction occurs between TCF4 and ATF5 (activating transcription factor 5) -a new member of cAMP response element binding protein (CREB) with the yeast two-hybrid system. The N-terminal and DNA binding domain of TCF4 (TCF4ND, 1-495 aa) and the C-terminal spanning bZIP domain of ATF5 (162-282 aa) were found to be responsible for the interaction, and the C-terminal of ATF5 (ATF5/C) showed a much stronger interaction with TCF4ND than the full-length of ATF5 by detecting the P-gal activity. Furthermore, overexpression of ATF5/C enhanced transcriptional activation by TCF4 proteins in luciferase assay by transient transfection. Taken together, these data suggest that ATF5 may function as a co-activator to potentiate the ability of TCF4 to activate transcription.

语种英语
WOS记录号WOS:000182411500014
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60623
专题北京大学第一临床医学院_泌尿外科
作者单位1.Tsing Hua Univ, Dept Biol Sci & Biotechnol, Tsinghua Inst Genome Res, Beijing 100084, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Phytol, Beijing 100083, Peoples R China
3.Peking Univ, Inst Urol, Hosp 1, Dept Urol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Ye, XJ,Zhang, ZW,Zhang, XJ,et al. Functional interaction of TCF4 with ATF5 to regulate the Wnt signaling pathway[J]. CHINESE SCIENCE BULLETIN,2003,48(7):668-672.
APA Ye, XJ.,Zhang, ZW.,Zhang, XJ.,Lin, GT.,Xiong, SQ.,...&Chang, ZJ.(2003).Functional interaction of TCF4 with ATF5 to regulate the Wnt signaling pathway.CHINESE SCIENCE BULLETIN,48(7),668-672.
MLA Ye, XJ,et al."Functional interaction of TCF4 with ATF5 to regulate the Wnt signaling pathway".CHINESE SCIENCE BULLETIN 48.7(2003):668-672.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Ye, XJ]的文章
[Zhang, ZW]的文章
[Zhang, XJ]的文章
百度学术
百度学术中相似的文章
[Ye, XJ]的文章
[Zhang, ZW]的文章
[Zhang, XJ]的文章
必应学术
必应学术中相似的文章
[Ye, XJ]的文章
[Zhang, ZW]的文章
[Zhang, XJ]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。