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学科主题: 临床医学
题名:
Functional interaction of TCF4 with ATF5 to regulate the Wnt signaling pathway
作者: Ye, XJ; Zhang, ZW; Zhang, XJ; Lin, GT; Xiong, SQ; Jin, GH; Han, L; Huang, SS; Chen, PL; Al, JK; Xin, DQ; Guo, YL; Chang, ZJ
关键词: TCF4 ; ATF5 ; protein-protein interaction ; Wnt signaling pathway ; gene regulation
刊名: CHINESE SCIENCE BULLETIN
发表日期: 2003-04-01
卷: 48, 期:7, 页:668-672
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: ELEMENT-BINDING-PROTEIN ; TRANSCRIPTION FACTORS ; EXPRESSION ; BIOLOGY ; CANCER ; CREB
英文摘要:

Wnt signaling directs cell-fate choices during embryonic development and tissue tumorigenesis. T cell factor 4 (TCF4) plays a pivotal role in the Wnt signaling pathway. We demonstrate that a specific protein-protein interaction occurs between TCF4 and ATF5 (activating transcription factor 5) -a new member of cAMP response element binding protein (CREB) with the yeast two-hybrid system. The N-terminal and DNA binding domain of TCF4 (TCF4ND, 1-495 aa) and the C-terminal spanning bZIP domain of ATF5 (162-282 aa) were found to be responsible for the interaction, and the C-terminal of ATF5 (ATF5/C) showed a much stronger interaction with TCF4ND than the full-length of ATF5 by detecting the P-gal activity. Furthermore, overexpression of ATF5/C enhanced transcriptional activation by TCF4 proteins in luciferase assay by transient transfection. Taken together, these data suggest that ATF5 may function as a co-activator to potentiate the ability of TCF4 to activate transcription.

语种: 英语
WOS记录号: WOS:000182411500014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60623
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Tsing Hua Univ, Dept Biol Sci & Biotechnol, Tsinghua Inst Genome Res, Beijing 100084, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Phytol, Beijing 100083, Peoples R China
3.Peking Univ, Inst Urol, Hosp 1, Dept Urol, Beijing 100083, Peoples R China

Recommended Citation:
Ye, XJ,Zhang, ZW,Zhang, XJ,et al. Functional interaction of TCF4 with ATF5 to regulate the Wnt signaling pathway[J]. CHINESE SCIENCE BULLETIN,2003,48(7):668-672.
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