IR@PKUHSC  > 北京大学药学院
学科主题药学
Phytochemical analysis of traditional Chinese medicine using liquid chromatography coupled with mass spectrometry
Yang, Min1; Sun, Jianghao2; Lu, Zhiqiang1; Chen, Guangtong1; Guan, Shuhong1; Liu, Xuan1; Jiang, Baohong1; Ye, Min2; Guo, De-An1,2
关键词Phytochemical analysis Traditional Chinese medicine HPLC-MS Tandem mass spectrometry Quality control
刊名JOURNAL OF CHROMATOGRAPHY A
2009-03-13
DOI10.1016/j.chroma.2008.08.097
1216期:11页:2045-2062
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]PRESSURE CHEMICAL-IONIZATION ; DIODE-ARRAY DETECTION ; OF-FLIGHT MASS ; RAPID STRUCTURAL-CHARACTERIZATION ; DIESTER-DITERPENOID ALKALOIDS ; RADIX SALVIA-MILTIORRHIZAE ; ZINGIBER-OFFICINALE ROSC. ; DAD-ESI-MSN ; ELECTROSPRAY-IONIZATION ; PHENOLIC-COMPOUNDS
英文摘要

Traditional Chinese medicine (TCM) is commonly considered to operate due to the synergistic effects of all the major and minor components in the medicines. Hence sensitive and comprehensive analytical techniques are needed to acquire a better understanding of the pharmacological basis of the herb and to enhance the product quality control. The present review mainly focuses on the phytochemical analysis of TCMs using high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS). Atmospheric pressure chemical ionization (APCI) and electrospray ionization (ESI) are the two commonly used ion sources. Triple quadrupole, ion trip (IT), Fourier transform ion cyclotron resonance (FTICR) and time-of-flight (TOF) mass spectrometers are used as on-line analyzer. The relationship between structural features and fragmentation patterns should be investigated as thoroughly as possible and hence be applied in the on-line analysis to deduce the Structures of detected peaks. Characteristic fragmentation behaviors of the reference standards, as well as information regarding polarity obtained from retention time data, on-line UV spectra, data from the literature and bio-sources of the compounds allowed the identification of the phytochemical constituents in the crude extracts. Although a mass spectrometer is not a universal detector, high-performance liquid chromatography Coupled with Multistage mass spectrometry (HPLC-MSn) technique was still proved to be a rapid and sensitive method to analyze the majority of the many constituents in herbal medicines, particularly for the detection of those present in minor or trace amounts. The methods established using HPLC-MS techniques facilitate the convenient and rapid quality control of traditional medicines and their pharmaceutical preparations. However, the quantitative analysis is not the topic of this review. (C) 2008 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000264226500010
项目编号2006BAI08B03-03
资助机构ministry of Sciences and Technology of China
引用统计
被引频次:128[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60624
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr TCM Modernizat, Shanghai 201203, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Yang, Min,Sun, Jianghao,Lu, Zhiqiang,et al. Phytochemical analysis of traditional Chinese medicine using liquid chromatography coupled with mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY A,2009,1216(11):2045-2062.
APA Yang, Min.,Sun, Jianghao.,Lu, Zhiqiang.,Chen, Guangtong.,Guan, Shuhong.,...&Guo, De-An.(2009).Phytochemical analysis of traditional Chinese medicine using liquid chromatography coupled with mass spectrometry.JOURNAL OF CHROMATOGRAPHY A,1216(11),2045-2062.
MLA Yang, Min,et al."Phytochemical analysis of traditional Chinese medicine using liquid chromatography coupled with mass spectrometry".JOURNAL OF CHROMATOGRAPHY A 1216.11(2009):2045-2062.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, Min]的文章
[Sun, Jianghao]的文章
[Lu, Zhiqiang]的文章
百度学术
百度学术中相似的文章
[Yang, Min]的文章
[Sun, Jianghao]的文章
[Lu, Zhiqiang]的文章
必应学术
必应学术中相似的文章
[Yang, Min]的文章
[Sun, Jianghao]的文章
[Lu, Zhiqiang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。