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学科主题临床医学
Response to pioglitazone treatment is associated with the lipoprotein lipase S447X variant in subjects with type 2 diabetes mellitus
Wang, G.; Wang, X.; Zhang, Q.; Ma, Z.
刊名INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
2007-04-01
DOI10.1111/j.1742-1241.2006.01242.x
61期:4页:552-557
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal ; Pharmacology & Pharmacy
研究领域[WOS]General & Internal Medicine ; Pharmacology & Pharmacy
关键词[WOS]CORONARY-ARTERY-DISEASE ; LOWERS BLOOD-PRESSURE ; INSULIN SENSITIVITY ; GLYCEMIC CONTROL ; CHOLESTEROL LEVELS ; HDL CHOLESTEROL ; TROGLITAZONE ; GENE ; HYPERTENSION ; GAMMA
英文摘要

To investigate the influence of the S447X variant in lipoprotein lipase (LPL) gene on the response rate to therapy with the thiazolidinedione pioglitazone. A total of 113 diabetic patients were treated with pioglitazone 30 mg for 10 weeks. Response to the pioglitazone treatment was defined by either a >10% relative reduction in fasting blood glucose (FBG) or a more than 1% decrease in glycosylated haemoglobin (HbA1c) values after 10 weeks of pioglitazone treatment. The genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism method. Using the criteria >10% relative reduction in FBG after 10 weeks of pioglitaone treatment, responder frequency to pioglitazone treatment in S447S genotype group is significantly higher than S447X genotype group. Meanwhile, the S447X genotype conferred a statistically significant 0.538-fold reduction in response rate to pioglitazone treatment relative to the S447S genotype. Moreover, pioglitazone treatment has significantly beneficial effects on serum lipid profile and blood pressure in S447S genotype carriers. The S447X variant in LPL gene may be a cause for therapy modification by pioglitazone.

语种英语
WOS记录号WOS:000245051600008
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60626
专题北京大学第三临床医学院_内分泌科
作者单位Peking Univ, Hosp 3, Dept Endocrinol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, G.,Wang, X.,Zhang, Q.,et al. Response to pioglitazone treatment is associated with the lipoprotein lipase S447X variant in subjects with type 2 diabetes mellitus[J]. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE,2007,61(4):552-557.
APA Wang, G.,Wang, X.,Zhang, Q.,&Ma, Z..(2007).Response to pioglitazone treatment is associated with the lipoprotein lipase S447X variant in subjects with type 2 diabetes mellitus.INTERNATIONAL JOURNAL OF CLINICAL PRACTICE,61(4),552-557.
MLA Wang, G.,et al."Response to pioglitazone treatment is associated with the lipoprotein lipase S447X variant in subjects with type 2 diabetes mellitus".INTERNATIONAL JOURNAL OF CLINICAL PRACTICE 61.4(2007):552-557.
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