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学科主题: 临床医学
题名:
Response to pioglitazone treatment is associated with the lipoprotein lipase S447X variant in subjects with type 2 diabetes mellitus
作者: Wang, G.; Wang, X.; Zhang, Q.; Ma, Z.
刊名: INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
发表日期: 2007-04-01
DOI: 10.1111/j.1742-1241.2006.01242.x
卷: 61, 期:4, 页:552-557
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal ; Pharmacology & Pharmacy
研究领域[WOS]: General & Internal Medicine ; Pharmacology & Pharmacy
关键词[WOS]: CORONARY-ARTERY-DISEASE ; LOWERS BLOOD-PRESSURE ; INSULIN SENSITIVITY ; GLYCEMIC CONTROL ; CHOLESTEROL LEVELS ; HDL CHOLESTEROL ; TROGLITAZONE ; GENE ; HYPERTENSION ; GAMMA
英文摘要:

To investigate the influence of the S447X variant in lipoprotein lipase (LPL) gene on the response rate to therapy with the thiazolidinedione pioglitazone. A total of 113 diabetic patients were treated with pioglitazone 30 mg for 10 weeks. Response to the pioglitazone treatment was defined by either a >10% relative reduction in fasting blood glucose (FBG) or a more than 1% decrease in glycosylated haemoglobin (HbA1c) values after 10 weeks of pioglitazone treatment. The genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism method. Using the criteria >10% relative reduction in FBG after 10 weeks of pioglitaone treatment, responder frequency to pioglitazone treatment in S447S genotype group is significantly higher than S447X genotype group. Meanwhile, the S447X genotype conferred a statistically significant 0.538-fold reduction in response rate to pioglitazone treatment relative to the S447S genotype. Moreover, pioglitazone treatment has significantly beneficial effects on serum lipid profile and blood pressure in S447S genotype carriers. The S447X variant in LPL gene may be a cause for therapy modification by pioglitazone.

语种: 英语
WOS记录号: WOS:000245051600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60626
Appears in Collections:北京大学第三临床医学院_内分泌科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Endocrinol, Beijing 100083, Peoples R China

Recommended Citation:
Wang, G.,Wang, X.,Zhang, Q.,et al. Response to pioglitazone treatment is associated with the lipoprotein lipase S447X variant in subjects with type 2 diabetes mellitus[J]. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE,2007,61(4):552-557.
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