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学科主题: 临床医学
题名:
Detection of breast cancer-related antigens through cDNA phage-displayed protein microarray
作者: Bi, Qun1; Tan, Taochao1; Xiang, Xi1; Lu, Aiping2; Zhu, Shenggeng1
关键词: breast tumor ; high-throughput screening ; microarray ; phase display ; related antigen ; serological identification
刊名: BIOLOGICAL CHEMISTRY
发表日期: 2010-07-01
DOI: 10.1515/BC.2010.075
卷: 391, 期:7, 页:831-835
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: CELLS ; CARCINOMA ; CLONES ; TARGET
英文摘要:

High-throughput molecular profiling techniques are helpful in the diagnosis of multifactorial disease. In this study, a cDNA-phage-displayed protein microarray using phage particles spotted directly onto it as sensors was used to detect related antigens in breast tumor sera. cDNA sequences from 17 positive clones were determined, which included some sequences encoding known breast cancer-related antigens and proteins related to other diseases, as well as proteins with unknown functions. Our results not only provide some useful information for breast cancer research, but also suggest that the strategy used here would be efficient to search for disease-related proteins and other functional target proteins.

语种: 英语
所属项目编号: 20333010
项目资助者: Nature Sciences Foundation of China
WOS记录号: WOS:000279573200016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60632
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Dept Pathol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100036, Peoples R China

Recommended Citation:
Bi, Qun,Tan, Taochao,Xiang, Xi,et al. Detection of breast cancer-related antigens through cDNA phage-displayed protein microarray[J]. BIOLOGICAL CHEMISTRY,2010,391(7):831-835.
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