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学科主题临床医学
Prognostic and predictive value of epigenetic biomarkers and clinical factors in upper tract urothelial carcinoma
Xiong, Gengyan1; Liu, Jin1; Tang, Qi1; Fan, Yu1; Fang, Dong1; Yang, Kaiwei1; Xie, Feng1; Zhang, Min1; Zhang, Lei1; Liu, Libo1; Zhang, Cuijian1; Yao, Lin1; Yang, Li2,3; Ci, Weimin4; Zhao, Wei5; Gong, Yanqing1; He, Qun1; Gong, Kan1; He, Zhisong1; Wang, Gang1; Li, Xuesong1; Guo, Yinglu1; Zhou, Liqun1
关键词epigenetic biomarkers nomogram oncological outcomes predictive model upper tract urothelial carcinoma
刊名EPIGENOMICS
2015
DOI10.2217/epi.15.34
7期:5页:733-744
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
研究领域[WOS]Genetics & Heredity
关键词[WOS]UPPER URINARY-TRACT ; TRANSITIONAL-CELL CARCINOMA ; BLADDER-CANCER ; RISK-FACTORS ; INTRAVESICAL RECURRENCE ; PROMOTER METHYLATION ; BREAST-CANCER ; NEPHROURETERECTOMY ; OUTCOMES ; TAIWAN
英文摘要

Aim: We conducted this study to identify gene promoter methylation status and clinical predictors for upper tract urothelial carcinoma (UTUC) patients. Materials & methods: Using methylation-sensitive PCR, we examined ten genes promoter methylation status in 687 UTUC patients. Results: A methylated promoter of three genes to predict higher tumor stage (T3 and T4), five genes to predict higher tumor grade (G3) and one gene to predict pN+ were certified in this study. Nine factors were significantly associated with poor cancer-specific survival. Six factors were considered as predictors to develop bladder recurrence after surgery. Conclusion: Methylation occurs commonly in UTUCs, may affect carcinogenic mechanisms, and is a well predictive factor for cancer-specific survival and bladder recurrence in UTUCs.

语种英语
WOS记录号WOS:000362820400007
项目编号BMU20120318 ; 7122183 ; 7152146 ; 81172419 ; 81372746 ; Z151100004015173
资助机构Collaborative Research Foundation of Peking University Health Science Center ; National Taiwan University, College of Medicine ; Natural Science Foundation of Beijing ; Natural Science Foundation of China ; Clinical Features Research of Capital
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60633
专题北京大学第一临床医学院_泌尿外科
北京大学药学院_化学生物学系
北京大学第二临床医学院_放射科
北京大学第一临床医学院_北京大学泌尿外科研究所
作者单位1.Peking Univ, Natl Urol Canc Ctr, Inst Urol, Hosp 1,Dept Urol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Div Nephrol, Beijing 100034, Peoples R China
4.Chinese Acad Sci, Beijing Inst Genom, Lab Dis Genom & Individualized Med, Beijing 100101, Peoples R China
5.Peking Univ, Canc Hosp & Inst, Dept Cell Biol, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Xiong, Gengyan,Liu, Jin,Tang, Qi,et al. Prognostic and predictive value of epigenetic biomarkers and clinical factors in upper tract urothelial carcinoma[J]. EPIGENOMICS,2015,7(5):733-744.
APA Xiong, Gengyan.,Liu, Jin.,Tang, Qi.,Fan, Yu.,Fang, Dong.,...&Zhou, Liqun.(2015).Prognostic and predictive value of epigenetic biomarkers and clinical factors in upper tract urothelial carcinoma.EPIGENOMICS,7(5),733-744.
MLA Xiong, Gengyan,et al."Prognostic and predictive value of epigenetic biomarkers and clinical factors in upper tract urothelial carcinoma".EPIGENOMICS 7.5(2015):733-744.
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