北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 血液科  > 期刊论文
学科主题: 临床医学
题名:
Late-onset Epstein-Barr virus-related disease in acute leukemia patients after haploidentical hematopoietic stem cell transplantation is associated with impaired early recovery of T and B lymphocytes
作者: Liu, Jiangying; Yan, Chenhua; Zhang, Chunli; Xu, Lanping; Liu, Yanrong; Huang, Xiaojun
关键词: acute leukemia ; EBV-related disease ; Epstein-Barr virus ; hematopoietic stem cell transplantation ; immune reconstitution
刊名: CLINICAL TRANSPLANTATION
发表日期: 2015-10-01
DOI: 10.1111/ctr.12593
卷: 29, 期:10, 页:904-910
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery ; Transplantation
研究领域[WOS]: Surgery ; Transplantation
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; ACUTE MYELOID-LEUKEMIA ; IMMUNE RECONSTITUTION ; LYMPHOPROLIFERATIVE DISEASE ; HEMATOLOGICAL MALIGNANCIES ; COUNTS ; LONG ; SCT
英文摘要:

Epstein-Barr virus-related disease (EBVD) is a serious clinical complication in patients who have undergone haploidentical hematopoietic stem cell transplantation (haploHSCT). Some recipients develop EBVD relatively late after haploHSCT, and most of these patients suffer a poor outcome. This retrospective cohort study characterized the early adaptive immune recovery of patients with acute leukemia presenting with EBVD more than 100d after haploHSCT. Patients with acute leukemia who received haploHSCT and developed EBVD 100d later (n=8) were compared with a matched control group without EBVD (n=24) with regard to peripheral WBC, lymphocytes, and neutrophils (at 30, 60, and 90d) and recoveries of B and T lymphocytes (at 30 and 90d, via immunophenotyping/flow cytometry). Ninety days after haploHSCT, the median values of WBCs and lymphocytes, and the recoveries of CD19(+) B cells and CD4(+), CD8(+), and CD4(+)CD45RO(+) T cells, were significantly lower in patients who developed EBVD, relative to the control group. These results suggest a significant association between deficient early recovery of B and T lymphocytes and the development of late-onset EBVD after haploHSCT. Our observation could facilitate clinical intervention and the improvement of overall survival of patients undergoing haploHSCT.

语种: 英语
所属项目编号: 81230013
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000362504100006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60636
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Peking Univ Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Jiangying,Yan, Chenhua,Zhang, Chunli,et al. Late-onset Epstein-Barr virus-related disease in acute leukemia patients after haploidentical hematopoietic stem cell transplantation is associated with impaired early recovery of T and B lymphocytes[J]. CLINICAL TRANSPLANTATION,2015,29(10):904-910.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Jiangying]'s Articles
[Yan, Chenhua]'s Articles
[Zhang, Chunli]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Jiangying]‘s Articles
[Yan, Chenhua]‘s Articles
[Zhang, Chunli]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace