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Late-onset Epstein-Barr virus-related disease in acute leukemia patients after haploidentical hematopoietic stem cell transplantation is associated with impaired early recovery of T and B lymphocytes
Liu, Jiangying; Yan, Chenhua; Zhang, Chunli; Xu, Lanping; Liu, Yanrong; Huang, Xiaojun
关键词acute leukemia EBV-related disease Epstein-Barr virus hematopoietic stem cell transplantation immune reconstitution
刊名CLINICAL TRANSPLANTATION
2015-10-01
DOI10.1111/ctr.12593
29期:10页:904-910
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery ; Transplantation
研究领域[WOS]Surgery ; Transplantation
关键词[WOS]BONE-MARROW-TRANSPLANTATION ; ACUTE MYELOID-LEUKEMIA ; IMMUNE RECONSTITUTION ; LYMPHOPROLIFERATIVE DISEASE ; HEMATOLOGICAL MALIGNANCIES ; COUNTS ; LONG ; SCT
英文摘要

Epstein-Barr virus-related disease (EBVD) is a serious clinical complication in patients who have undergone haploidentical hematopoietic stem cell transplantation (haploHSCT). Some recipients develop EBVD relatively late after haploHSCT, and most of these patients suffer a poor outcome. This retrospective cohort study characterized the early adaptive immune recovery of patients with acute leukemia presenting with EBVD more than 100d after haploHSCT. Patients with acute leukemia who received haploHSCT and developed EBVD 100d later (n=8) were compared with a matched control group without EBVD (n=24) with regard to peripheral WBC, lymphocytes, and neutrophils (at 30, 60, and 90d) and recoveries of B and T lymphocytes (at 30 and 90d, via immunophenotyping/flow cytometry). Ninety days after haploHSCT, the median values of WBCs and lymphocytes, and the recoveries of CD19(+) B cells and CD4(+), CD8(+), and CD4(+)CD45RO(+) T cells, were significantly lower in patients who developed EBVD, relative to the control group. These results suggest a significant association between deficient early recovery of B and T lymphocytes and the development of late-onset EBVD after haploHSCT. Our observation could facilitate clinical intervention and the improvement of overall survival of patients undergoing haploHSCT.

语种英语
WOS记录号WOS:000362504100006
项目编号81230013
资助机构National Natural Science Foundation of China
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60636
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Peking Univ Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100871, Peoples R China
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GB/T 7714
Liu, Jiangying,Yan, Chenhua,Zhang, Chunli,et al. Late-onset Epstein-Barr virus-related disease in acute leukemia patients after haploidentical hematopoietic stem cell transplantation is associated with impaired early recovery of T and B lymphocytes[J]. CLINICAL TRANSPLANTATION,2015,29(10):904-910.
APA Liu, Jiangying,Yan, Chenhua,Zhang, Chunli,Xu, Lanping,Liu, Yanrong,&Huang, Xiaojun.(2015).Late-onset Epstein-Barr virus-related disease in acute leukemia patients after haploidentical hematopoietic stem cell transplantation is associated with impaired early recovery of T and B lymphocytes.CLINICAL TRANSPLANTATION,29(10),904-910.
MLA Liu, Jiangying,et al."Late-onset Epstein-Barr virus-related disease in acute leukemia patients after haploidentical hematopoietic stem cell transplantation is associated with impaired early recovery of T and B lymphocytes".CLINICAL TRANSPLANTATION 29.10(2015):904-910.
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