北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 中国药物依赖性研究所  > 期刊论文
学科主题: 药物依赖
题名:
Circadian alteration in neurobiology during protracted opiate withdrawal in rats
作者: Li, Su-xia1; Liu, Li-jing1; Jiang, Wen-gao1; Sun, Li-li1; Zhou, Shuang-jiang1; Le Foll, Bernard2; Zhang, Xiang Yang3; Kosten, Thomas R.3; Lu, Lin1
关键词: circadian rhythm ; clock genes ; hormone ; morphine dependence ; peptides ; protracted withdrawal
刊名: JOURNAL OF NEUROCHEMISTRY
发表日期: 2010-10-01
DOI: 10.1111/j.1471-4159.2010.06941.x
卷: 115, 期:2, 页:353-362
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: VENTRAL TEGMENTAL AREA ; METHADONE-INDUCED HYPOADRENALISM ; BLOOD MONONUCLEAR-CELLS ; SUPRACHIASMATIC NUCLEUS ; MORPHINE-WITHDRAWAL ; PREFRONTAL CORTEX ; GENE-EXPRESSION ; CLOCK GENES ; COCAINE SENSITIZATION ; HEROIN ABSTINENCE
英文摘要:

P>Protracted opiate withdrawal can extend for months of disrupted hormonal circadian rhythms. We examined rodent behaviors and these circadian disturbances in hormone and peptide levels as well as brain clock gene expression during 60 days of protracted withdrawal. Our behavioral tests included open field, elevated plus maze, and sucrose preference tests at 36 h, 10, 30, and 60 days after stopping chronic morphine. At these four assessment points, we collected samples every 4 h for 24 h to examine circadian rhythms in blood hormone and peptide levels and brain expression of rPER1, rPER2, and rPER3 clock genes. Decreased locomotor activity and elevated adrenocorticotropic hormone and melatonin levels persisted for 2 months after morphine withdrawal, but corticosterone was elevated only at 36 h and 10 days after withdrawal. Orexin levels were high at 36 h after withdrawal, but then reversed during protracted withdrawal to abnormally low levels. Beta-endorphin (beta-EP) levels showed no differences from normal. However, circadian rhythms were blunted for all of these hormones. Corticosterone, adrenocorticotropic hormone, and orexin blunting persisted at least for 60 days. The blunted circadian rhythm of beta-EP and melatonin recovered by day 60, but the peak phase of beta-EP was delayed about 8 h. Blunted circadian rhythms and reduced expression of rPER1, rPER2, and rPER3 persisted at least for 60 days in the suprachiasmatic nucleus, prefrontal cortex, nucleus accumbens core, central nucleus of the amygdala, Hippocampus, and ventral tegmental area. Circadian rhythms of rPER1 in the nucleus accumbens shell and basolateral nucleus of the amygdala and of rPER2 in the central nucleus of the amygdala were reversed. Disrupted circadian rhythms of rPER1, rPER 2, and rPER3 expression in reward-related brain circuits and blunted circadian rhythms in peripheral hormones and peptides may play a role in protracted opiate withdrawal and contribute to relapse.

语种: 英语
所属项目编号: 2007CB512302 ; 09G0762 ; K05 DA0454
项目资助者: National Basic Research Program of China ; Natural Science Foundation of Beijing Municipality ; National Institute on Drug Abuse
WOS记录号: WOS:000282571300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60642
Appears in Collections:中国药物依赖性研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Ctr Addict & Mental Hlth, Translat Addict Res Lab, Toronto, ON, Canada
3.Baylor Coll Med, Div Alcohol & Addict Disorders, Houston, TX 77030 USA

Recommended Citation:
Li, Su-xia,Liu, Li-jing,Jiang, Wen-gao,et al. Circadian alteration in neurobiology during protracted opiate withdrawal in rats[J]. JOURNAL OF NEUROCHEMISTRY,2010,115(2):353-362.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Li, Su-xia]'s Articles
[Liu, Li-jing]'s Articles
[Jiang, Wen-gao]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Li, Su-xia]‘s Articles
[Liu, Li-jing]‘s Articles
[Jiang, Wen-gao]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
 !E
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace