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Incubation of alcohol craving during abstinence in patients with alcohol dependence
Li, Peng1,2,3; Wu, Ping3; Xin, Xue4; Fan, Yun-Li5; Wang, Gui-Bin6,7; Wang, Fan5; Ma, Meng-Ying5; Xue, Ming-Ming4; Luo, Yi-Xiao1,2,3; Yang, Fu-De5; Bao, Yan-Ping; Shi, Jie3; Sun, Hong-Qiang1,2; Lu, Lin1,2,3
关键词Alcohol dependence craving incubation physiological reaction
刊名ADDICTION BIOLOGY
2015-05-01
DOI10.1111/adb.12140
20期:3页:513-522
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Substance Abuse
资助者National Natural Science Foundation of China ; Training Program Foundation for Excellent Talents by the Beijing Municipal Government, China ; National Natural Science Foundation of China ; Training Program Foundation for Excellent Talents by the Beijing Municipal Government, China
研究领域[WOS]Biochemistry & Molecular Biology ; Substance Abuse
关键词[WOS]RELAPSE PREVENTION ; PREFRONTAL CORTEX ; SIGNALING PATHWAY ; COCAINE SEEKING ; CUE-REACTIVITY ; USE DISORDERS ; RATS ; WITHDRAWAL ; HEROIN ; METAANALYSIS
英文摘要

Time-dependent increases in cue-induced nicotine and methamphetamine craving during abstinence were recently reported in human drug-dependent individuals. In the present study, we sought to determine whether this incubation of craving′ phenomenon also occurs in alcoholics. Four groups of 80 inpatient adult male alcoholics were assessed in a single session (between-group design) for cue-induced alcohol craving at 7, 14, 30 and 60 days of abstinence. Another group that included 19 patients was repeatedly tested for cue-induced alcohol craving at the same abstinence days as above. Other psychological and physiological measures were assessed at the four abstinence timepoints. Cue-induced alcohol craving measured with visual analogue scales was the highest at 60 days of abstinence both between and within groups. However, heart rate, blood pressure and skin conductance responses did not differ between abstinent groups. These results provide evidence of the incubation of alcohol craving in humans, extending previous reports with smokers and methamphetamine addicts.

语种英语
所属项目编号81271475 ; 31230033 ; 81221002 ; 2010D003034000026
资助者National Natural Science Foundation of China ; Training Program Foundation for Excellent Talents by the Beijing Municipal Government, China ; National Natural Science Foundation of China ; Training Program Foundation for Excellent Talents by the Beijing Municipal Government, China
WOS记录号WOS:000352652200009
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60644
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
4.Inner Mongolia Med Univ, Basic Med Coll, Dept Physiol, Hohhot, Peoples R China
5.Peking Univ, Beijing Hui Long Guan Hosp, Dept Alcohol & Drug Dependence, Beijing 100191, Peoples R China
6.Chinese Acad Med Sci, Inst Mat Med, Beijing, Peoples R China
7.Peking Union Med Coll, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Li, Peng,Wu, Ping,Xin, Xue,et al. Incubation of alcohol craving during abstinence in patients with alcohol dependence[J]. ADDICTION BIOLOGY,2015,20(3):513-522.
APA Li, Peng.,Wu, Ping.,Xin, Xue.,Fan, Yun-Li.,Wang, Gui-Bin.,...&Lu, Lin.(2015).Incubation of alcohol craving during abstinence in patients with alcohol dependence.ADDICTION BIOLOGY,20(3),513-522.
MLA Li, Peng,et al."Incubation of alcohol craving during abstinence in patients with alcohol dependence".ADDICTION BIOLOGY 20.3(2015):513-522.
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