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学科主题: 精神卫生
题名:
Incubation of alcohol craving during abstinence in patients with alcohol dependence
作者: Li, Peng1,2,3; Wu, Ping3; Xin, Xue4; Fan, Yun-Li5; Wang, Gui-Bin6,7; Wang, Fan5; Ma, Meng-Ying5; Xue, Ming-Ming4; Luo, Yi-Xiao1,2,3; Yang, Fu-De5; Bao, Yan-Ping; Shi, Jie3; Sun, Hong-Qiang1,2; Lu, Lin1,2,3
关键词: Alcohol dependence ; craving ; incubation ; physiological reaction
刊名: ADDICTION BIOLOGY
发表日期: 2015-05-01
DOI: 10.1111/adb.12140
卷: 20, 期:3, 页:513-522
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Substance Abuse
研究领域[WOS]: Biochemistry & Molecular Biology ; Substance Abuse
关键词[WOS]: RELAPSE PREVENTION ; PREFRONTAL CORTEX ; SIGNALING PATHWAY ; COCAINE SEEKING ; CUE-REACTIVITY ; USE DISORDERS ; RATS ; WITHDRAWAL ; HEROIN ; METAANALYSIS
英文摘要:

Time-dependent increases in cue-induced nicotine and methamphetamine craving during abstinence were recently reported in human drug-dependent individuals. In the present study, we sought to determine whether this incubation of craving′ phenomenon also occurs in alcoholics. Four groups of 80 inpatient adult male alcoholics were assessed in a single session (between-group design) for cue-induced alcohol craving at 7, 14, 30 and 60 days of abstinence. Another group that included 19 patients was repeatedly tested for cue-induced alcohol craving at the same abstinence days as above. Other psychological and physiological measures were assessed at the four abstinence timepoints. Cue-induced alcohol craving measured with visual analogue scales was the highest at 60 days of abstinence both between and within groups. However, heart rate, blood pressure and skin conductance responses did not differ between abstinent groups. These results provide evidence of the incubation of alcohol craving in humans, extending previous reports with smokers and methamphetamine addicts.

语种: 英语
所属项目编号: 81271475 ; 31230033 ; 81221002 ; 2010D003034000026
项目资助者: National Natural Science Foundation of China ; Training Program Foundation for Excellent Talents by the Beijing Municipal Government, China
WOS记录号: WOS:000352652200009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60644
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
4.Inner Mongolia Med Univ, Basic Med Coll, Dept Physiol, Hohhot, Peoples R China
5.Peking Univ, Beijing Hui Long Guan Hosp, Dept Alcohol & Drug Dependence, Beijing 100191, Peoples R China
6.Chinese Acad Med Sci, Inst Mat Med, Beijing, Peoples R China
7.Peking Union Med Coll, Beijing, Peoples R China

Recommended Citation:
Li, Peng,Wu, Ping,Xin, Xue,et al. Incubation of alcohol craving during abstinence in patients with alcohol dependence[J]. ADDICTION BIOLOGY,2015,20(3):513-522.
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