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学科主题: 基础医学
题名:
Hemorheological abnormalities in lipoprotein lipase deficient mice with severe hypertriglyceridemia
作者: Zhao, TQ; Guo, J; Li, H; Huang, W; Xian, XD; Ross, CJD; Hayden, MR; Wen, ZY; Liu, G
关键词: hypertriglyceridemia ; lipoprotein lipase ; hemorheology
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2006-03-24
DOI: 10.1016/j.bbrc.2006.01.067
卷: 341, 期:4, 页:1066-1071
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: LPLS447X BENEFICIAL MUTATION ; PLASMA VISCOSITY ; HYPERLIPIDEMIC PANCREATITIS ; GENE-TRANSFER ; RBC MEMBRANE ; RISK-FACTORS ; NULL MICE ; TRIGLYCERIDES ; HYPERLIPOPROTEINEMIA ; DYSLIPOPROTEINEMIAS
英文摘要:

Severe hypertriglyceridemia (HTG) is a metabolic disturbance often seen in clinical practice. It is known to induce life-threatening acute pancreatitis, but its role in atherogenesis remains elusive. Hemorheological abnormality was thought to play an important role in pathogenesis of both pancreatitis and atherosclerosis. However, hemorheology in severe HTG was not well investigated. Recently, we established a severe HTG mouse model deficient in lipoprotein lipase (LPL) in which severe HTG was observed to cause a significant increase in plasma viscosity. Disturbances of erythrocytes were also documented, including decreased deformability, electrophoresis rate, and membrane fluidity, and increased osmotic fragility. Scanning electron microscopy demonstrated that most erythrocytes of LPL deficient mice deformed with protrusions, irregular appearances or indistinct concaves. Analysis of erythrocyte membrane lipids showed decreased cholesterol (Ch) and phospholipid (PL) contents but unaltered Ch/PL ratio. The changes of membrane lipids may be partially responsible for the hemorheological and morphologic abnormalities of erythrocytes. This study indicated that severe HTG could lead to significant impairment of hemorheology and this model may be useful in delineating the role of severe HTG in the pathogenesis of hyperlipidemic pancreatitis and atherosclerosis. (c) 2006 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000235699900025
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60646
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Biophys, Hemorheol Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100083, Peoples R China
3.Univ British Columbia, Ctr Mol Med & Therapeut, Dept Med Genet, Vancouver, BC V5Z 1M9, Canada

Recommended Citation:
Zhao, TQ,Guo, J,Li, H,et al. Hemorheological abnormalities in lipoprotein lipase deficient mice with severe hypertriglyceridemia[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,341(4):1066-1071.
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