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Radionuclide imaging of mesenchymal stem cells transplanted into spinal cord
Bai, JZ; Ding, WIIM; Yu, MJ; Du, J; Liu, ZJ; Jia, B; Li, LS; Shen, L; Tian, JH; Wang, F
关键词in vivo tracking mesenchymal stem cell radionuclide imaging spinal cord transferrin receptor transplantation
刊名NEUROREPORT
2004-05-19
DOI10.1097/01.wnr.0000126505.97607.1b
15期:7页:1117-1120
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]TRANSFERRIN-RECEPTOR ; BRAIN-BARRIER ; DIFFERENTIATE ; BLOOD
英文摘要

In vivo tracking of stem cells implanted to spinal cord by radionuclide imaging was investigated. The high expression of transferrin receptor on human mesenchymal stem cells (hMSCs) was verified by flow cytometry, radioligand binding and immunofluorescence. Radiolabelled transferrin was chosen as a tracer for scintigraphic imaging of the hMSCs transplanted into spinal cord of rabbits. Comparative experiments with radiolabelled human serum albumin as tracer and PBS as graft as well as ex vivo autoradiography demonstrated the specific uptake of radiolabelled transferrin of hMSCs. hMSCs could be detected in vivo with radiolabelled transferrin targeting at cellular transferrin receptors at an early stage after transplantation into spinal cord.

语种英语
WOS记录号WOS:000225140400007
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60648
专题北京大学医药卫生分析中心
作者单位1.Peking Univ, Med Isotopes Res Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Dept Orthoped, Beijing 100083, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Nucl Med, Beijing 100853, Peoples R China
4.Peking Univ, Stem Cell Res Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Bai, JZ,Ding, WIIM,Yu, MJ,et al. Radionuclide imaging of mesenchymal stem cells transplanted into spinal cord[J]. NEUROREPORT,2004,15(7):1117-1120.
APA Bai, JZ.,Ding, WIIM.,Yu, MJ.,Du, J.,Liu, ZJ.,...&Wang, F.(2004).Radionuclide imaging of mesenchymal stem cells transplanted into spinal cord.NEUROREPORT,15(7),1117-1120.
MLA Bai, JZ,et al."Radionuclide imaging of mesenchymal stem cells transplanted into spinal cord".NEUROREPORT 15.7(2004):1117-1120.
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