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学科主题: 公共卫生
题名:
Radionuclide imaging of mesenchymal stem cells transplanted into spinal cord
作者: Bai, JZ; Ding, WIIM; Yu, MJ; Du, J; Liu, ZJ; Jia, B; Li, LS; Shen, L; Tian, JH; Wang, F
关键词: in vivo tracking ; mesenchymal stem cell ; radionuclide imaging ; spinal cord ; transferrin receptor ; transplantation
刊名: NEUROREPORT
发表日期: 2004-05-19
DOI: 10.1097/01.wnr.0000126505.97607.1b
卷: 15, 期:7, 页:1117-1120
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: TRANSFERRIN-RECEPTOR ; BRAIN-BARRIER ; DIFFERENTIATE ; BLOOD
英文摘要:

In vivo tracking of stem cells implanted to spinal cord by radionuclide imaging was investigated. The high expression of transferrin receptor on human mesenchymal stem cells (hMSCs) was verified by flow cytometry, radioligand binding and immunofluorescence. Radiolabelled transferrin was chosen as a tracer for scintigraphic imaging of the hMSCs transplanted into spinal cord of rabbits. Comparative experiments with radiolabelled human serum albumin as tracer and PBS as graft as well as ex vivo autoradiography demonstrated the specific uptake of radiolabelled transferrin of hMSCs. hMSCs could be detected in vivo with radiolabelled transferrin targeting at cellular transferrin receptors at an early stage after transplantation into spinal cord.

语种: 英语
WOS记录号: WOS:000225140400007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60648
Appears in Collections:北京大学医药卫生分析中心_期刊论文

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作者单位: 1.Peking Univ, Med Isotopes Res Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Dept Orthoped, Beijing 100083, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Nucl Med, Beijing 100853, Peoples R China
4.Peking Univ, Stem Cell Res Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Bai, JZ,Ding, WIIM,Yu, MJ,et al. Radionuclide imaging of mesenchymal stem cells transplanted into spinal cord[J]. NEUROREPORT,2004,15(7):1117-1120.
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