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学科主题: 基础医学
题名:
Pretreatment with Andrographolide Pills (R) Attenuates Lipopolysaccharide-Induced Pulmonary Microcirculatory Disturbance and Acute Lung Injury in Rats
作者: Yang, Ning1,2,3,4; Liu, Yu-Ying1,4; Pan, Chun-Shui1,4; Sun, Kai1,4; Wei, Xiao-Hong1,4; Mao, Xiao-Wei2,4; Lin, Fang1; Li, Xue-Jun3; Fan, Jing-Yu1,4; Han, Jing-Yan1,2,4
关键词: leukocytes adhesion ; hyperpermeability ; caveolin-1 ; Src kinase
刊名: MICROCIRCULATION
发表日期: 2014-11-01
DOI: 10.1111/micc.12152
卷: 21, 期:8, 页:703-716
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: KAPPA-B ACTIVATION ; ENDOTHELIAL PERMEABILITY ; NADPH OXIDASE ; HOST-DEFENSE ; TNF-ALPHA ; INFLAMMATION ; NEUTROPHILS ; CAVEOLIN-1 ; PROTECTS ; ADHESION
英文摘要:

ObjectiveThe purpose of this study was to explore the protective effect of AP on LPS-induced PMD and ALI.

MethodsMale SD rats were continuously infused with LPS (5mg/kg/h) for one hour to induce PMD and ALI. AP was administrated orally one hour before LPS exposure. Arterial blood pressure and HR were monitored. Blood gas analysis, histological observation, cytokines in plasma, leukocyte recruitment, pulmonary oxidative stress, microvessel permeability, edema, and related proteins were evaluated six hours after LPS challenge.

ResultsRats receiving LPS exhibited significant alterations, including hypotension, tachycardia, increase in cytokines, neutrophil adhesion and infiltration, oxidative stress, and microvessel hyperpermeability, resulting in pulmonary injury and dysfunction. AP (0.18g/kg or 1.8g/kg) improved rat survival rate, and significantly attenuated all aforementioned insults, and inhibited LPS-induced increase in adhesion molecules, up-regulation of Cav-1 and Src kinase and NADPH oxidase subunits (p47(phox) and p67(phox)) membrane translocation in lung tissue, and preserved JAM-1 and claudin-5.

ConclusionsThe results demonstrated the protective effect of AP on LPS-induced PMD and ALI, suggesting the potential of AP as a prophylactic strategy for LPS-induced ALI.

语种: 英语
所属项目编号: 2008ZX09401
项目资助者: Production of New Medicine Program of Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000344789400004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60649
Appears in Collections:基础医学院_北大医学部天士力微循环研究中心_期刊论文

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作者单位: 1.Peking Univ Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China
4.State Adm Tradit Chinese Med China, Key Lab Microcirculat, Beijing, Peoples R China

Recommended Citation:
Yang, Ning,Liu, Yu-Ying,Pan, Chun-Shui,et al. Pretreatment with Andrographolide Pills (R) Attenuates Lipopolysaccharide-Induced Pulmonary Microcirculatory Disturbance and Acute Lung Injury in Rats[J]. MICROCIRCULATION,2014,21(8):703-716.
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