学科主题基础医学
Pretreatment with Andrographolide Pills (R) Attenuates Lipopolysaccharide-Induced Pulmonary Microcirculatory Disturbance and Acute Lung Injury in Rats
Yang, Ning1,2,3,4; Liu, Yu-Ying1,4; Pan, Chun-Shui1,4; Sun, Kai1,4; Wei, Xiao-Hong1,4; Mao, Xiao-Wei2,4; Lin, Fang1; Li, Xue-Jun3; Fan, Jing-Yu1,4; Han, Jing-Yan1,2,4
关键词leukocytes adhesion hyperpermeability caveolin-1 Src kinase
刊名MICROCIRCULATION
2014-11-01
DOI10.1111/micc.12152
21期:8页:703-716
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]KAPPA-B ACTIVATION ; ENDOTHELIAL PERMEABILITY ; NADPH OXIDASE ; HOST-DEFENSE ; TNF-ALPHA ; INFLAMMATION ; NEUTROPHILS ; CAVEOLIN-1 ; PROTECTS ; ADHESION
英文摘要

ObjectiveThe purpose of this study was to explore the protective effect of AP on LPS-induced PMD and ALI.

MethodsMale SD rats were continuously infused with LPS (5mg/kg/h) for one hour to induce PMD and ALI. AP was administrated orally one hour before LPS exposure. Arterial blood pressure and HR were monitored. Blood gas analysis, histological observation, cytokines in plasma, leukocyte recruitment, pulmonary oxidative stress, microvessel permeability, edema, and related proteins were evaluated six hours after LPS challenge.

ResultsRats receiving LPS exhibited significant alterations, including hypotension, tachycardia, increase in cytokines, neutrophil adhesion and infiltration, oxidative stress, and microvessel hyperpermeability, resulting in pulmonary injury and dysfunction. AP (0.18g/kg or 1.8g/kg) improved rat survival rate, and significantly attenuated all aforementioned insults, and inhibited LPS-induced increase in adhesion molecules, up-regulation of Cav-1 and Src kinase and NADPH oxidase subunits (p47(phox) and p67(phox)) membrane translocation in lung tissue, and preserved JAM-1 and claudin-5.

ConclusionsThe results demonstrated the protective effect of AP on LPS-induced PMD and ALI, suggesting the potential of AP as a prophylactic strategy for LPS-induced ALI.

语种英语
WOS记录号WOS:000344789400004
项目编号2008ZX09401
资助机构Production of New Medicine Program of Ministry of Science and Technology of the People&prime ; s Republic of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60649
专题北京大学基础医学院_北大医学部天士力微循环研究中心
北京大学基础医学院
作者单位1.Peking Univ Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China
4.State Adm Tradit Chinese Med China, Key Lab Microcirculat, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Yang, Ning,Liu, Yu-Ying,Pan, Chun-Shui,et al. Pretreatment with Andrographolide Pills (R) Attenuates Lipopolysaccharide-Induced Pulmonary Microcirculatory Disturbance and Acute Lung Injury in Rats[J]. MICROCIRCULATION,2014,21(8):703-716.
APA Yang, Ning.,Liu, Yu-Ying.,Pan, Chun-Shui.,Sun, Kai.,Wei, Xiao-Hong.,...&Han, Jing-Yan.(2014).Pretreatment with Andrographolide Pills (R) Attenuates Lipopolysaccharide-Induced Pulmonary Microcirculatory Disturbance and Acute Lung Injury in Rats.MICROCIRCULATION,21(8),703-716.
MLA Yang, Ning,et al."Pretreatment with Andrographolide Pills (R) Attenuates Lipopolysaccharide-Induced Pulmonary Microcirculatory Disturbance and Acute Lung Injury in Rats".MICROCIRCULATION 21.8(2014):703-716.
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