IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Elevated HOXB9 expression promotes differentiation and predicts a favourable outcome in colon adenocarcinoma patients
Zhan, J.1,2,3; Niu, M.1,2,3; Wang, P.1,2,3; Zhu, X.1,4; Li, S.1,2,3; Song, J.1,2,3; He, H.1,4; Wang, Y.1,2,5; Xue, L.1,6; Fang, W.1,4; Zhang, H.1,2,3
关键词HOXB9 colon adenocarcinoma differentiation mesenchymal-to-epithelial transition metastasis
刊名BRITISH JOURNAL OF CANCER
2014-08-26
DOI10.1038/bjc.2014.387
111期:5页:883-893
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]GENE-EXPRESSION ; TIGHT JUNCTIONS ; BREAST-CANCER ; COLORECTAL-CANCER ; HOMEOBOX B9 ; IN-VITRO ; METASTASIS ; TUMOR ; CARCINOMA ; GROWTH
英文摘要

Background: Little is known about the tumour suppressive proteins and the underlying mechanisms that suppress colon cancer progression. Homeodomain-containing transcription factor HOXB9 plays an important role in embryogenesis and cancer development. We here aim to uncover the potential role of HOXB9 in the regulation of colon adenocarcinoma progression including epithelial-to-mesenchymal transition.

Methods: HOXB9 expression in colon adenocarcinoma cells and patients was analysed by western blot and immunohistochemistry separately. Correlation between HOXB9 expressions with patients′ survival was assessed by Kaplan-Meier analysis. HOXB9-regulated target gene expression was determined by RNA sequencing in HOXB9-overexpressing colon adenocarcinoma cells.

Results: Elevated HOXB9 expression was identified in well-differentiated colon adenocarcinoma patients and was associated with a better overall patients′ survival. Overexpression of HOXB9 inhibited colon adenocarcinoma cell growth, migration, invasion in vitro and tumour growth, liver as well as lung metastases in nude mice; whereas silencing HOXB9 promoted these functions. HOXB9 promoted colon adenocarcinoma differentiation via a mechanism that stimulates mesenchymal-to-epithelial transition, involving downregulation of EMT-promoting transcriptional factors including Snail, Twist, FOXC2 and ZEB1 and upregulation of epithelial proteins including E-cadherin, claudins-1, -4, -7, occludin and ZO-1.

Conclusions: HOXB9 is a novel tumour suppressor that inhibits colon adenocarcinoma progression by inducing differentiation. Elevated expression of HOXB9 predicts a longer survival in colon adenocarcinoma patients.

语种英语
WOS记录号WOS:000341527100010
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60655
专题北京大学基础医学院_病理学系
北京大学基础医学院
北京大学第二临床医学院_国际合作办公室
作者单位1.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Hlth Sci Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Lab Mol Cell Biol & Tumor Biol, Dept Anat Histol & Embryol, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Pathol, Lab Mol Pathol, Beijing 100191, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Res, Beijing 100191, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Dept Biochem, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhan, J.,Niu, M.,Wang, P.,et al. Elevated HOXB9 expression promotes differentiation and predicts a favourable outcome in colon adenocarcinoma patients[J]. BRITISH JOURNAL OF CANCER,2014,111(5):883-893.
APA Zhan, J..,Niu, M..,Wang, P..,Zhu, X..,Li, S..,...&Zhang, H..(2014).Elevated HOXB9 expression promotes differentiation and predicts a favourable outcome in colon adenocarcinoma patients.BRITISH JOURNAL OF CANCER,111(5),883-893.
MLA Zhan, J.,et al."Elevated HOXB9 expression promotes differentiation and predicts a favourable outcome in colon adenocarcinoma patients".BRITISH JOURNAL OF CANCER 111.5(2014):883-893.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Elevated HOXB9 expre(2137KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhan, J.]的文章
[Niu, M.]的文章
[Wang, P.]的文章
百度学术
百度学术中相似的文章
[Zhan, J.]的文章
[Niu, M.]的文章
[Wang, P.]的文章
必应学术
必应学术中相似的文章
[Zhan, J.]的文章
[Niu, M.]的文章
[Wang, P.]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Elevated HOXB9 expression promotes differentiation and predicts a favourable outcome in colon adenocarcinoma patients.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。