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学科主题: 精神卫生
题名:
Decreased BDNF in serum of patients with chronic schizophrenia on long-term treatment with antipsychotics
作者: Tan, YL; Zhou, DF; Cao, LY; Zou, YZ; Zhang, XY
关键词: schizophrenia ; brain-derived neurotrophic factor ; psychopathology ; antipsychotics ; serum ; neurotrophin
刊名: NEUROSCIENCE LETTERS
发表日期: 2005-07-01
DOI: 10.1016/j.neulet.2005.02.054
卷: 382, 期:1-2, 页:27-32
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: NEUROTROPHIC FACTOR EXPRESSION ; RAT-BRAIN ; PREFRONTAL CORTEX ; MESSENGER-RNA ; RECEPTOR ; DOPAMINE ; HIPPOCAMPUS ; INHIBITION ; TRANSPORT
英文摘要:

Accumulating evidence suggests BDNF as a molecule involved in the pathophysiology of schizophrenia. To examine the BDNF levels and the relationship between BDNF levels and psychopathology in patients with schizophrenia, 81 physically healthy patients with schizophrenia were compared with 45 age-, sex- matched normal controls. The psychopathology of patients were assessed by the Positive and Negative Syndrome Scale (PANSS). Serum BDNF levels were measured by sandwich ELISA. The results showed that BDNF-like immunoreactivity were significantly lower in medicated patients with chronic schizophrenia than in healthy control subjects. A significant negative correlation between BDNF-like immunoreactivity and PANSS negative subscore was observed. As compared with normal controls, there was a significant decrease in BDNF-like immunoreactivity in patients treated with both atypical and typical antipsychotics. However, no correlation between standardized drug doses and BDNF-like immunoreactivity was found. These findings suggest that serum BDNF levels in chronic schizophrenia under antipsychotic medication may be decreased. However, long-term effects of antipsychotics remain to be characterized. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000229661900006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60663
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Beijing Hui Long Guan Hosp, Beijing 100096, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
3.Yale Univ, Sch Med, CA Connecticut Healthcare Syst, Dept Psychiat, West Haven, CT 06516 USA

Recommended Citation:
Tan, YL,Zhou, DF,Cao, LY,et al. Decreased BDNF in serum of patients with chronic schizophrenia on long-term treatment with antipsychotics[J]. NEUROSCIENCE LETTERS,2005,382(1-2):27-32.
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