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Decreased BDNF in serum of patients with chronic schizophrenia on long-term treatment with antipsychotics
Tan, YL; Zhou, DF; Cao, LY; Zou, YZ; Zhang, XY
关键词schizophrenia brain-derived neurotrophic factor psychopathology antipsychotics serum neurotrophin
刊名NEUROSCIENCE LETTERS
2005-07-01
DOI10.1016/j.neulet.2005.02.054
382期:1-2页:27-32
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]NEUROTROPHIC FACTOR EXPRESSION ; RAT-BRAIN ; PREFRONTAL CORTEX ; MESSENGER-RNA ; RECEPTOR ; DOPAMINE ; HIPPOCAMPUS ; INHIBITION ; TRANSPORT
英文摘要

Accumulating evidence suggests BDNF as a molecule involved in the pathophysiology of schizophrenia. To examine the BDNF levels and the relationship between BDNF levels and psychopathology in patients with schizophrenia, 81 physically healthy patients with schizophrenia were compared with 45 age-, sex- matched normal controls. The psychopathology of patients were assessed by the Positive and Negative Syndrome Scale (PANSS). Serum BDNF levels were measured by sandwich ELISA. The results showed that BDNF-like immunoreactivity were significantly lower in medicated patients with chronic schizophrenia than in healthy control subjects. A significant negative correlation between BDNF-like immunoreactivity and PANSS negative subscore was observed. As compared with normal controls, there was a significant decrease in BDNF-like immunoreactivity in patients treated with both atypical and typical antipsychotics. However, no correlation between standardized drug doses and BDNF-like immunoreactivity was found. These findings suggest that serum BDNF levels in chronic schizophrenia under antipsychotic medication may be decreased. However, long-term effects of antipsychotics remain to be characterized. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000229661900006
Citation statistics
Cited Times:99[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60663
Collection北京大学精神卫生研究所
作者单位1.Beijing Hui Long Guan Hosp, Beijing 100096, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
3.Yale Univ, Sch Med, CA Connecticut Healthcare Syst, Dept Psychiat, West Haven, CT 06516 USA
Recommended Citation
GB/T 7714
Tan, YL,Zhou, DF,Cao, LY,et al. Decreased BDNF in serum of patients with chronic schizophrenia on long-term treatment with antipsychotics[J]. NEUROSCIENCE LETTERS,2005,382(1-2):27-32.
APA Tan, YL,Zhou, DF,Cao, LY,Zou, YZ,&Zhang, XY.(2005).Decreased BDNF in serum of patients with chronic schizophrenia on long-term treatment with antipsychotics.NEUROSCIENCE LETTERS,382(1-2),27-32.
MLA Tan, YL,et al."Decreased BDNF in serum of patients with chronic schizophrenia on long-term treatment with antipsychotics".NEUROSCIENCE LETTERS 382.1-2(2005):27-32.
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