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学科主题临床医学
Genetic polymorphisms of the E-cadherin promoter and risk of sporadic gastric carcinoma in Chinese populations
Zhang, Baozhen1; Pan, Kaifeng2; Liu, Zhaojun1; Zhou, Jing1; Gu, Liankun1; Ji, Jiafu3; Ma, Junling2; You, Wei-cheng2; Deng, Dajun1
刊名CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
2008-09-01
DOI10.1158/1055-9965.EPI-08-0315
17期:9页:2402-2408
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Public, Environmental & Occupational Health
研究领域[WOS]Oncology ; Public, Environmental & Occupational Health
关键词[WOS]SINGLE NUCLEOTIDE POLYMORPHISM ; INVASION-SUPPRESSOR GENE ; HELICOBACTER-PYLORI ; PROSTATE-CANCER ; STOMACH-CANCER ; BREAST-CANCER ; HIGH-GRADE ; EXPRESSION ; MUTATIONS ; ASSOCIATION
英文摘要

Frequent mutations and loss of expression of E-cadherin have been reported in a number of cancers. E-cadherin germ line mutations lead to a high risk of familial diffused gastric carcinoma. In the present study, to evaluate the effect of genetic polymorphisms in the E-cadherin promoter on the risk of sporadic gastric carcinoma (SGC), a comprehensive study was conducted in two populations with high and low risk of SGC in China, respectively. Five hundred seventy-two SGC cases and 625 controls from low-risk area and 589 individuals enrolled in a long-term follow-up survey in high-risk area were studied. Polymorphisms of E-cadherin around transcription start site (-437 to +314) were analyzed by sequencing. Five variations of -347de/> A, -160C > A, -73A > C, +178T > C, and +234 13N ins > del were linked tightly. The -347del/del and its strongly linked +178T/T, +234 13N ins/ins genotypes increased male SGC risk in the high-risk area significantly [odds ratio (OR), 2.22; 95% confidence intervals (95% CD, 1.10-4.46] and correlated with the severity of gastric lesions. A synergetic effect was also observed between -347del/del genotype and Helicobacter pylori infection (OR, 4.93; 95% CI, 1.65-14.71). Compared with -347del-containing haplotypes, the -347A-containing haplotype [A((-347))-C(-160)-A((-73))-C(+178)-13N del((+234))] decreased the risk of SGC among male subjects (OR, 0.61; 95% CI, 0.37-1.01). Such correlation could not be observed among subjects from the low-risk area. The present data suggest that the -347del allele of E-cadherin strongly links with the +178T and +234 13N ins alleles. The -347del/del genotype may increase the susceptibility of SGC among males in the high-risk area of China.

语种英语
WOS记录号WOS:000259211400031
项目编号BA711A06 ; 2005CB522403
资助机构Key Technologies and Development Program of China 2002 ; National Basic Research Program of China
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60668
专题北京大学临床肿瘤学院_病因研究室
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
北京大学临床肿瘤学院_病因学研究室
北京大学临床肿瘤学院_流行病学研究室
北京大学临床肿瘤学院_党院办公室
作者单位1.Peking Univ, Dept Etiol, Sch Oncol, Beijing Canc Hosp Inst, Beijing 100036, Peoples R China
2.Peking Univ, Dept Canc Epidemiol, Sch Oncol, Beijing Canc Hosp Inst, Beijing 100036, Peoples R China
3.Peking Univ, Dept Surg, Sch Oncol, Beijing Canc Hosp Inst, Beijing 100036, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Baozhen,Pan, Kaifeng,Liu, Zhaojun,et al. Genetic polymorphisms of the E-cadherin promoter and risk of sporadic gastric carcinoma in Chinese populations[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,2008,17(9):2402-2408.
APA Zhang, Baozhen.,Pan, Kaifeng.,Liu, Zhaojun.,Zhou, Jing.,Gu, Liankun.,...&Deng, Dajun.(2008).Genetic polymorphisms of the E-cadherin promoter and risk of sporadic gastric carcinoma in Chinese populations.CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,17(9),2402-2408.
MLA Zhang, Baozhen,et al."Genetic polymorphisms of the E-cadherin promoter and risk of sporadic gastric carcinoma in Chinese populations".CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 17.9(2008):2402-2408.
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