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学科主题: 临床医学
题名:
Genetic polymorphisms of the E-cadherin promoter and risk of sporadic gastric carcinoma in Chinese populations
作者: Zhang, Baozhen1; Pan, Kaifeng2; Liu, Zhaojun1; Zhou, Jing1; Gu, Liankun1; Ji, Jiafu3; Ma, Junling2; You, Wei-cheng2; Deng, Dajun1
刊名: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
发表日期: 2008-09-01
DOI: 10.1158/1055-9965.EPI-08-0315
卷: 17, 期:9, 页:2402-2408
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Public, Environmental & Occupational Health
研究领域[WOS]: Oncology ; Public, Environmental & Occupational Health
关键词[WOS]: SINGLE NUCLEOTIDE POLYMORPHISM ; INVASION-SUPPRESSOR GENE ; HELICOBACTER-PYLORI ; PROSTATE-CANCER ; STOMACH-CANCER ; BREAST-CANCER ; HIGH-GRADE ; EXPRESSION ; MUTATIONS ; ASSOCIATION
英文摘要:

Frequent mutations and loss of expression of E-cadherin have been reported in a number of cancers. E-cadherin germ line mutations lead to a high risk of familial diffused gastric carcinoma. In the present study, to evaluate the effect of genetic polymorphisms in the E-cadherin promoter on the risk of sporadic gastric carcinoma (SGC), a comprehensive study was conducted in two populations with high and low risk of SGC in China, respectively. Five hundred seventy-two SGC cases and 625 controls from low-risk area and 589 individuals enrolled in a long-term follow-up survey in high-risk area were studied. Polymorphisms of E-cadherin around transcription start site (-437 to +314) were analyzed by sequencing. Five variations of -347de/> A, -160C > A, -73A > C, +178T > C, and +234 13N ins > del were linked tightly. The -347del/del and its strongly linked +178T/T, +234 13N ins/ins genotypes increased male SGC risk in the high-risk area significantly [odds ratio (OR), 2.22; 95% confidence intervals (95% CD, 1.10-4.46] and correlated with the severity of gastric lesions. A synergetic effect was also observed between -347del/del genotype and Helicobacter pylori infection (OR, 4.93; 95% CI, 1.65-14.71). Compared with -347del-containing haplotypes, the -347A-containing haplotype [A((-347))-C(-160)-A((-73))-C(+178)-13N del((+234))] decreased the risk of SGC among male subjects (OR, 0.61; 95% CI, 0.37-1.01). Such correlation could not be observed among subjects from the low-risk area. The present data suggest that the -347del allele of E-cadherin strongly links with the +178T and +234 13N ins alleles. The -347del/del genotype may increase the susceptibility of SGC among males in the high-risk area of China.

语种: 英语
所属项目编号: BA711A06 ; 2005CB522403
项目资助者: Key Technologies and Development Program of China 2002 ; National Basic Research Program of China
WOS记录号: WOS:000259211400031
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60668
Appears in Collections:北京大学临床肿瘤学院_病因研究室_期刊论文

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作者单位: 1.Peking Univ, Dept Etiol, Sch Oncol, Beijing Canc Hosp Inst, Beijing 100036, Peoples R China
2.Peking Univ, Dept Canc Epidemiol, Sch Oncol, Beijing Canc Hosp Inst, Beijing 100036, Peoples R China
3.Peking Univ, Dept Surg, Sch Oncol, Beijing Canc Hosp Inst, Beijing 100036, Peoples R China

Recommended Citation:
Zhang, Baozhen,Pan, Kaifeng,Liu, Zhaojun,et al. Genetic polymorphisms of the E-cadherin promoter and risk of sporadic gastric carcinoma in Chinese populations[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,2008,17(9):2402-2408.
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