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学科主题临床医学
Long Noncoding RNA HOTAIR Is Associated with Motility, Invasion, and Metastatic Potential of Metastatic Melanoma
Tang, Lihua1; Zhang, Wei2,3; Su, Bing2,3; Yu, Bo1,3,4,5
刊名BIOMED RESEARCH INTERNATIONAL
2013
DOI10.1155/2013/251098
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
资助者Research Grants of Shenzhen Science and Technology project ; Research Grants of Shenzhen Science and Technology project
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]PROSTATE-SPECIFIC GENE ; CELL LUNG-CANCER ; TILING ARRAYS ; GENOME ; IDENTIFICATION ; COMPLEXITY ; CARCINOMA ; BREAST ; PCGEM1 ; STATE
英文摘要

Metastatic melanoma, the primary cause of skin cancer-related death, warrants new therapeutic approaches that target the regulatory machinery at molecular level. While long noncoding RNAs (lncRNAs) are dysregulated in a number of cancer types, limited data are available on the expression and function of lncRNAs in melanoma metastasis. The primary objective of this study was to investigate the role of 6 metastasis-related lncRNAs in pairs of primary melanoma and matched lymph node metastatic tissues. Among the tested lncRNAs, HOTAIR was the most highly expressed in lymph node metastasis. The role of HOTAIR in melanoma cell motility and invasion was further evaluated by knocking down HOTAIR with siRNAs. Knockdown of HOTAIR resulted in the reduction of motility and invasion of human melanoma cell line A375, as assessed by wound healing assay and Matrigel-based invasion assay. siHOTAIR also suppressed the degradation of gelatin matrix, suggesting that HOTAIR promotes gelatinase activity. Together, our study shows that HOTAIR is overexpressed in metastatic tissue, which is associated with the ability of HOTAIR to promote melanoma cell motility and invasion. These data indicate that lncRNAs may be involved in the metastasis of melanoma and provide support for further evaluation of lncRNAs in melanoma.

语种英语
所属项目编号ZYA201106080030A
资助者Research Grants of Shenzhen Science and Technology project ; Research Grants of Shenzhen Science and Technology project
WOS记录号WOS:000320552600001
引用统计
被引频次:54[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60670
专题北京大学深圳医院
作者单位1.Anhui Med Univ, Affiliated Shenzhen Hosp, Hefei 230001, Anhui, Peoples R China
2.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen 518036, Guangdong, Peoples R China
3.Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Translat Med Dermatol, Shenzhen 518036, Guangdong, Peoples R China
4.Peking Univ, Shenzhen Hosp, Shenzhen Key Discipline Dermatol, Shenzhen 518036, Guangdong, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen 518036, Guangdong, Peoples R China
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Tang, Lihua,Zhang, Wei,Su, Bing,et al. Long Noncoding RNA HOTAIR Is Associated with Motility, Invasion, and Metastatic Potential of Metastatic Melanoma[J]. BIOMED RESEARCH INTERNATIONAL,2013.
APA Tang, Lihua,Zhang, Wei,Su, Bing,&Yu, Bo.(2013).Long Noncoding RNA HOTAIR Is Associated with Motility, Invasion, and Metastatic Potential of Metastatic Melanoma.BIOMED RESEARCH INTERNATIONAL.
MLA Tang, Lihua,et al."Long Noncoding RNA HOTAIR Is Associated with Motility, Invasion, and Metastatic Potential of Metastatic Melanoma".BIOMED RESEARCH INTERNATIONAL (2013).
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