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学科主题: 公共卫生
题名:
Effect of marine collagen peptides on long bone development in growing rats
作者: Xu, YaJun; Han, XiaoLong; Li, Yong
关键词: marine collagen peptides ; bone turnover ; bone mineral density ; bone biomechanics
刊名: JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
发表日期: 2010-07-01
DOI: 10.1002/jsfa.3972
卷: 90, 期:9, 页:1485-1491
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
研究领域[WOS]: Agriculture ; Chemistry ; Food Science & Technology
关键词[WOS]: SALMON ONCORHYNCHUS-KETA ; FOOD-DERIVED PEPTIDES ; MINERAL DENSITY ; FAT MASS ; CASEIN PHOSPHOPEPTIDES ; MECHANICAL-PROPERTIES ; RELATIVE CONTRIBUTION ; PREMENOPAUSAL WOMEN ; AGE ; MILK
英文摘要:

BACKGROUND: Nutritional factors play an important role in skeletal development during growth. However, the absorption rates of many bone-related minerals are relatively low from traditional diets, especially for people in Asia and Africa. In the present study, the effect of marine collagen peptides (MCP) derived from chum salmon (Oncorhynchus keta) skin on the development of femurs in growing rats of both sexes was investigated.

RESULTS: MCP supplementation could increase the size, mineral density, dry weight, ash weight, content of most minerals and both stiffness and toughness of femurs in male growing rats. However, such effects were milder in female rats. The reported increase in mineral density was likely to be related to increased osteoblast activity rather than a decreased rate of bone resorption, as an increase in serum osteocalcin and bone-specific alkaline phosphatase content was observed, but no significant difference in serum N-terminal telopeptide of type I collagen compared with control was found.

CONCLUSION: MCP supplementation could promote the development of long bones in growing male rats. (C) 2010 Society of Chemical Industry

语种: 英语
所属项目编号: CO30103 ; 2006BAK02A07-6
项目资助者: National Natural Science Foundation of China ; National Key Technology RD Program
WOS记录号: WOS:000279414500015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60672
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Food Hyg & Nutr, Sch Publ Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Xu, YaJun,Han, XiaoLong,Li, Yong. Effect of marine collagen peptides on long bone development in growing rats[J]. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,2010,90(9):1485-1491.
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