学科主题临床医学
Expression of CIITA-related MHCII molecules in tumors linked to prognosis in hepatocellular carcinoma
Xie, Xing-Wang1; Mei, Ming-Hui3; Liao, Wei-Jia3; Qian, Li-Hua2; Yu, Xin4; Fei, Ran1; Qin, Li-Ling3; Zhang, Heng-Hui1; Peng, Ji-Run4; Shen, Dan-Hua2; Wei, Lai1; Chen, Hong-Song1
关键词hepatocellular carcinoma recurrence CIITA MHC II genes microarray gene expression profile
刊名INTERNATIONAL JOURNAL OF ONCOLOGY
2009-03-01
DOI10.3892/ijo_00000194
34期:3页:681-688
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Natural Science Foundation of China ; National Key Sci-Tech Special Project of China ; Program for New Century Excellent Talents ; Guangxi Scientific Research and Technological Development Project ; GEO accession numbers: microarray platform ; National Natural Science Foundation of China ; National Key Sci-Tech Special Project of China ; Program for New Century Excellent Talents ; Guangxi Scientific Research and Technological Development Project ; GEO accession numbers: microarray platform
研究领域[WOS]Oncology
关键词[WOS]EARLY INTRAHEPATIC RECURRENCE ; CLASS-II TRANSACTIVATOR ; GASTRIC-CANCER CELLS ; HLA-DR EXPRESSION ; INTERFERON-GAMMA ; OLIGONUCLEOTIDE MICROARRAY ; PREDICTION ; TRANSCRIPTION ; INACTIVATION ; METASTASIS
英文摘要

The prognosis of hepatocellular carcinoma (HCC) after surgery is poor due to its high recurrence rate. In order to unfold the mechanism of different recurrent-free survival (RFS) times following resection, expression profiling of tumor tissues from 32 HCC patients with different RFS time were used to identify differential expression of individual genes and signaling pathway components correlated with RFS time. Quantitative RT-PCR, Western blotting, and immunohistochemistry were used to validate the expression of selected genes. Up-regulation of several immune related genes and pathways, especially HLA II-related antigen presenting pathways, significantly correlated with longer RFS time. The expression of MHCII molecules were found to be mainly located in either CD68(+) cells or CD45(+) cells, and their expression significantly correlated with the expression of CIITA (HLA II genes transactivator) in the tumor. The results suggest that the high expression level of CIITA and MHCII molecules in hepatocellular carcinoma tissue is an effective prognostic marker for longer RFS time in HCC.

语种英语
所属项目编号30772499 ; 2008ZX10002-019 ; 985-2-099-113 ; 0428005-7 ; GPL4525 ; GSE11260
资助者National Natural Science Foundation of China ; National Key Sci-Tech Special Project of China ; Program for New Century Excellent Talents ; Guangxi Scientific Research and Technological Development Project ; GEO accession numbers: microarray platform ; National Natural Science Foundation of China ; National Key Sci-Tech Special Project of China ; Program for New Century Excellent Talents ; Guangxi Scientific Research and Technological Development Project ; GEO accession numbers: microarray platform
WOS记录号WOS:000263573600011
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60675
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Guilin Med Univ, Guilin 541000, Guangxi Prov, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Pathol, Beijing 100044, Peoples R China
4.Peking Univ, Peoples Hosp, Ctr Hepatobiliary Surg, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Xie, Xing-Wang,Mei, Ming-Hui,Liao, Wei-Jia,et al. Expression of CIITA-related MHCII molecules in tumors linked to prognosis in hepatocellular carcinoma[J]. INTERNATIONAL JOURNAL OF ONCOLOGY,2009,34(3):681-688.
APA Xie, Xing-Wang.,Mei, Ming-Hui.,Liao, Wei-Jia.,Qian, Li-Hua.,Yu, Xin.,...&Chen, Hong-Song.(2009).Expression of CIITA-related MHCII molecules in tumors linked to prognosis in hepatocellular carcinoma.INTERNATIONAL JOURNAL OF ONCOLOGY,34(3),681-688.
MLA Xie, Xing-Wang,et al."Expression of CIITA-related MHCII molecules in tumors linked to prognosis in hepatocellular carcinoma".INTERNATIONAL JOURNAL OF ONCOLOGY 34.3(2009):681-688.
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