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学科主题: 临床医学
题名:
Changes in Adrenomedullin in Patients with Proliferative Diabetic Retinopathy
作者: Lu, Yao1; Xu, Yimin1; Tang, Chaoshu2
关键词: Adrenomedullin ; Proliferative diabetic retinopathy ; Vitreous ; Radioimmunoassay ; Diabetic macular edema
刊名: CURRENT EYE RESEARCH
发表日期: 2011-11-01
DOI: 10.3109/02713683.2011.594200
卷: 36, 期:11, 页:1047-1052
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: ELEVATED ADRENOMEDULLIN ; PLASMA ADRENOMEDULLIN ; CELLS ; COMPLICATIONS ; EXPRESSION ; SECRETION ; MELLITUS ; HYPOXIA
英文摘要:

Purpose: To measure adrenomedullin (ADM) levels in the blood, vitreous fluid and fibrous membrane in patients with proliferative diabetic retinopathy (PDR) and study its changes in different pathological conditions.

Methods: We used radioimmunoassay technique to determine immunoreactive- adrenomedullin (IR-ADM) concentrations in the plasma, vitreous samples and fibrous membrane obtained from 9 control subjects with idiopathic macular hole and 23 patients with PDR undergoing vitrectomy.

Results: IR-ADM levels in the plasma, vitreous samples and fibrous membrane tissues (16.1 +/- 2.91fmol/ml, 9.80 +/- 2.51fmol/ml and 34.8 +/- 5.22fmol/mg) were all significantly elevated in patients with PDR compared with control subjects (11.6 +/- 2.38 fmol/ml, 5.8 +/- 1.64 fmol/ml and 22.4 +/- 1.72 fmol/mg). The levels of ADM in vitreous were also significantly higher in PDR patients with diabetic macular edema (DME) (11.2 +/- 2.36 fmol/ml) than those of patients without DME (8.0 +/- 1.11 fmol/ml) and controls (5.8 +/- 1.64 fmol/ml).

Conclusions: These findings suggest that ADM may be produced locally in the eyes and may correlate with the severity and proliferative reactions of diabetic retinopathy.

语种: 英语
WOS记录号: WOS:000295888200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60676
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Ophthalmol, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100871, Peoples R China

Recommended Citation:
Lu, Yao,Xu, Yimin,Tang, Chaoshu. Changes in Adrenomedullin in Patients with Proliferative Diabetic Retinopathy[J]. CURRENT EYE RESEARCH,2011,36(11):1047-1052.
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