北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Adaptable synthesis of C-lactosyl glycoclusters and their binding properties with galectin-3
作者: Yao, Wang; Xia, Meng-jie; Meng, Xiang-bao; Li, Qing; Li, Zhong-jun
刊名: ORGANIC & BIOMOLECULAR CHEMISTRY
发表日期: 2014
DOI: 10.1039/c4ob01374c
卷: 12, 期:41, 页:8180-8195
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: CROSS-COUPLING APPROACH ; CLICK CHEMISTRY ; BACTERIAL LECTIN ; CELL ACTIVATION ; PEANUT LECTIN ; HIGH-AFFINITY ; CARBOHYDRATE ; DERIVATIVES ; INHIBITORS ; GLYCOSIDES
英文摘要:

We report here the syntheses of mono-to tetravalent glycoclusters containing 1-methylene-C-beta-lactose. The 1-methylene-C-beta-lactose moiety has been synthesized from octa-acetyl-beta-lactose using the key carbonyl insertion reaction and linked to a series of alkynlated scaffolds via CuAAC reaction to afford mono-to tetravalent glycoclusters. The binding affinities of the final products to galectin-3 were found in the range of 10-100 mu M.

语种: 英语
所属项目编号: 2012CB822100 ; 2012ZX09502001001 ; 91213301 ; 21232002 ; 21172015
项目资助者: National Basic Research Program of China (973 Program) ; National Key Technology R&amp ; D Program "New Drug Innovation" of China ; National Natural Science Foundation of China
WOS记录号: WOS:000342760800009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60678
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Yao, Wang,Xia, Meng-jie,Meng, Xiang-bao,et al. Adaptable synthesis of C-lactosyl glycoclusters and their binding properties with galectin-3[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2014,12(41):8180-8195.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yao, Wang]'s Articles
[Xia, Meng-jie]'s Articles
[Meng, Xiang-bao]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yao, Wang]‘s Articles
[Xia, Meng-jie]‘s Articles
[Meng, Xiang-bao]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace