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Coenzyme Q10 for Parkinson′s disease
Liu, Jia1; Wang, Luning1; Zhan, Si-Yan2; Xia, Yinyin2
刊名COCHRANE DATABASE OF SYSTEMATIC REVIEWS
2011
DOI10.1002/14651858.CD008150.pub2
12
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]Q(10) ; TRIAL ; DOPAMINE
英文摘要

Background

A number of preclinical studies in both in vitro and in vivo models of Parkinson′s disease have demonstrated that coenzyme Q10 can protect the nigrostriatal dopaminergic system. Some clinical trials have looked at the neuroprotective effects of coenzyme Q10 in patients with early and midstage Parkinson′s disease.

Objectives

To assess the evidence from randomized controlled trials on the efficacy and safety of treatment with coenzyme Q10 compared to placebo in patients with early and midstage Parkinson′s disease.

Search methods

We searched the Cochrane Movment Disorders Group Trials Register, CENTRAL (The Cochrane Library 2009, Issue 4), MEDLINE (January 1966 to March 2011), and EMBASE (January 1985 to March 2011). We handsearched the references quoted in the identified trials, congress reports from the most important neurological association and movement disorder societies in Europe and America (March 2011), checked reference lists of relevant studies and contacted other researchers.

Selection criteria

We included randomized controlled trials (RCTs) that compared coenzyme Q10 to placebo for patients who suffered early and midstage primary Parkinson′s disease. Studies in which the method of randomization or concealment were unknown were included. Cross-over studies were excluded.

Data collection and analysis

Two review authors independently assessed trial quality and extracted data. All disagreements were resolved by consensus between authors and were explained. We attempted to contact the authors of studies for further details if any data were missing and to establish the characteristics of unpublished trials through correspondence with the trial coordinator or principal investigator. Adverse effects information was collected from the trials.

Main results

Four randomized, double-blind, placebo-controlled trials with a total of 452 patients met the inclusion criteria and were included in the review. In overall, there were improvements in activities of daily living (ADL) UPDRS (WMD -3.12, 95% CI -5.88 to -0.36) and Schwab and England (WMD 4.43, 95% CI 0.05 to 8.81) for coenzyme Q10 at 1200 mg/d for 16 months versus placebo.

In safety outcomes, only the risk ratios (RR) of pharyngitis (RR 1.04, 95% CI 0.18 to 5.89) and diarrhea (RR 1.39, 95% CI 0.62 to 3.16) are mild elevated between coenzyme Q10 therapy and placebo and there were no differences in the number of withdrawals due to adverse effects (RR 0.61, 95% CI 0.23 to 1.62).

Authors′ conclusions

Coenzyme Q10 therapy with 1200 mg/d for 16 months was well tolerated by patients with Parkinson′s disease. The improvements in ADL UPDRS and Schwab and England were positive, but it need to be further confirmed by larger sample. For total and other subscores of UPDRS, the effects of coenzyme Q10 seemed to be less clear.

语种英语
WOS记录号WOS:000300937600061
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60687
专题北京大学公共卫生学院
作者单位1.Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Neurol, Beijing 100853, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Liu, Jia,Wang, Luning,Zhan, Si-Yan,et al. Coenzyme Q10 for Parkinson′s disease[J]. COCHRANE DATABASE OF SYSTEMATIC REVIEWS,2011(12).
APA Liu, Jia,Wang, Luning,Zhan, Si-Yan,&Xia, Yinyin.(2011).Coenzyme Q10 for Parkinson′s disease.COCHRANE DATABASE OF SYSTEMATIC REVIEWS(12).
MLA Liu, Jia,et al."Coenzyme Q10 for Parkinson′s disease".COCHRANE DATABASE OF SYSTEMATIC REVIEWS .12(2011).
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