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IR@PKUHSC  > 北京大学临床肿瘤学院  > 胃肠肿瘤中心  > 期刊论文
学科主题: 临床医学
题名:
Validation of the Memorial Sloan-Kettering Cancer Center Nomogram to Predict Disease-Specific Survival after R0 Resection in a Chinese Gastric Cancer Population
作者: Chen, Donglai1; Jiang, Beihai2; Xing, Jiadi2; Liu, Maoxing2; Cui, Ming2; Liu, Yiqiang3; Wang, Zaozao2; Chen, Lei2; Yang, Hong2; Zhang, Chenghai2; Yao, Zhendan2; Zhang, Nan2; Ji, Jiafu4; Qu, Hong1; Su, Xiangqian2
刊名: PLOS ONE
发表日期: 2013-10-17
DOI: 10.1371/journal.pone.0076041
卷: 8, 期:10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: US-DERIVED NOMOGRAM ; PROGNOSTIC NOMOGRAM ; INDIVIDUAL SURVIVAL ; UNITED-STATES ; CARCINOMA ; RECURRENCE ; SURGERY ; KOREA
英文摘要:

Background: Prediction of disease-specific survival (DSS) for individual patient with gastric cancer after R0 resection remains a clinical concern. Since the clinicopathologic characteristics of gastric cancer vary widely between China and western countries, this study is to evaluate a nomogram from Memorial Sloan-Kettering Cancer Center (MSKCC) for predicting the probability of DSS in patients with gastric cancer from a Chinese cohort.

Methods: From 1998 to 2007, clinical data of 979 patients with gastric cancer who underwent R0 resection were retrospectively collected from Peking University Cancer Hospital & Institute and used for external validation. The performance of the MSKCC nomogram in our population was assessed using concordance index (C-index) and calibration plot.

Results: The C-index for the MSKCC predictive nomogram was 0.74 in the Chinese cohort, compared with 0.69 for American Joint Committee on Cancer (AJCC) staging system (P<0.0001). This suggests that the discriminating value of MSKCC nomogram is superior to AJCC staging system for prognostic prediction in the Chinese population. Calibration plots showed that the actual survival of Chinese patients corresponded closely to the MSKCC nonogram-predicted survival probabilities. Moreover, MSKCC nomogram predictions demonstrated the heterogeneity of survival in stage IIA/IIB/IIIA/IIIB disease of the Chinese patients.

Conclusion: In this study, we externally validated MSKCC nomogram for predicting the probability of 5- and 9-year DSS after R0 resection for gastric cancer in a Chinese population. The MSKCC nomogram performed well with good discrimination and calibration. The MSKCC nomogram improved individualized predictions of survival, and may assist Chinese clinicians and patients in individual follow-up scheduling, and decision making with regard to various treatment options.

语种: 英语
所属项目编号: 81272766 ; 31171270 ; 81071658 ; 2009-2093 ; Z121107001012130 ; 7132054 ; 2011060
项目资助者: National Natural Science Foundation of China ; Capital Medical Development and Research Foundation ; Clinical Characteristics and Application Research of Capital (Beijing Municipal Science &amp ; Technology Commission) ; Beijing Natural Science Foundation ; New Star of Science and Technology Program of Beijing (Beijing Municipal Science &amp ; Technology Commission)
WOS记录号: WOS:000326022200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60691
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

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作者单位: 1.Peking Univ, Coll Life Sci, State Key Lab Prot & Plant Gene Res, Ctr Bioinformat, Beijing 100871, Peoples R China
2.Peking Univ Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res Minist Educ, Dept Minimally Invas Gastrointestinal Surg, Beijing, Peoples R China
3.Peking Univ Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res Minist Educ, Dept Pathol, Beijing, Peoples R China
4.Peking Univ Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res Minist Educ, Dept Surg, Beijing, Peoples R China

Recommended Citation:
Chen, Donglai,Jiang, Beihai,Xing, Jiadi,et al. Validation of the Memorial Sloan-Kettering Cancer Center Nomogram to Predict Disease-Specific Survival after R0 Resection in a Chinese Gastric Cancer Population[J]. PLOS ONE,2013,8(10).
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