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Experimental occlusal interference induces long-term masticatory muscle hyperalgesia in rats
Cao, Ye1,4; Xie, Qiu-Fei1,4; Li, Kai2,4; Light, Alan R.3; Fu, Kai-Yuan2,4
关键词Occlusal interference Muscle pain Mechanical hyperalgesia Central sensitization Animal model
刊名PAIN
2009-08-01
DOI10.1016/j.pain.2009.04.029
144期:3页:287-293
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Anesthesiology ; Clinical Neurology ; Neurosciences
研究领域[WOS]Anesthesiology ; Neurosciences & Neurology
关键词[WOS]MEDULLARY DORSAL-HORN ; NMDA RECEPTOR MECHANISMS ; TOOTH-PULP STIMULATION ; TUMOR-NECROSIS-FACTOR ; C-FOS EXPRESSION ; TEMPOROMANDIBULAR DISORDERS ; TRAUMATIC OCCLUSION ; CRANIOMANDIBULAR DISORDERS ; ELECTROMYOGRAPHIC ACTIVITY ; CRANIOFACIAL PAIN
英文摘要

Temporomandibular joint or related masticatory Muscle pain represents the most common chronic orofacial pain condition. Patients frequently report this kind of pain after dental alterations in Occlusion. However, lack of understanding of the mechanisms Of occlusion-related temporomandibular joint and muscle pain prevents treating this problem successfully. To explore the relationship between improper occlusion (occlusal interference) and masticatory muscle pain, we created all occlusal interference animal model by directly bonding a crown to a maxillary molar to raise the masticating surface of the tooth in rats. We raised the occlusal Surface to three different heights (0.2, 0.4, and 0.6 mm), and for one month we quantitatively measured mechanical nociceptive thresholds of the temporal and masseter muscles oil both sides. Results showed a stimulus-response relationship between the height Of occlusal interference and muscle hyperalgesia. Removal of the crown 6 days after occlusal interference showed that the removal at this time Could not terminate the I month duration of mechanical hyperalgesia in the masticatory muscles. Lastly, we systemically administered NMDA antagonist MK801 (0.2, 0.1, and 0.05 mg/kg) to the treated rats and found that MK801 dose dependently attenuated the occlusal interference-induced hyperalgesia. These findings suggest that occlusal interference is directly related to masticatory muscle pain, and that central sensitization mechanisms are involved in the maintenance of the occlusal interference-induced mechanical hyperalgesia. (C) 2009 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000268442300013
资助机构New Century Excellent Talents in University (NCET)
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60694
专题北京大学口腔医学院_口腔修复科
北京大学公共卫生学院_公共卫生学院
北京大学口腔医学院_口腔放射科
作者单位1.Hosp Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Dept Prosthodont, Sch Stomatol, Beijing 100081, Peoples R China
3.Peking Univ, Ctr TMD & Orofacial Pain, Sch Stomatol, Beijing 100081, Peoples R China
4.Univ Utah, Dept Anesthesiol, Salt Lake City, UT 84132 USA
推荐引用方式
GB/T 7714
Cao, Ye,Xie, Qiu-Fei,Li, Kai,et al. Experimental occlusal interference induces long-term masticatory muscle hyperalgesia in rats[J]. PAIN,2009,144(3):287-293.
APA Cao, Ye,Xie, Qiu-Fei,Li, Kai,Light, Alan R.,&Fu, Kai-Yuan.(2009).Experimental occlusal interference induces long-term masticatory muscle hyperalgesia in rats.PAIN,144(3),287-293.
MLA Cao, Ye,et al."Experimental occlusal interference induces long-term masticatory muscle hyperalgesia in rats".PAIN 144.3(2009):287-293.
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