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学科主题: 临床医学
题名:
Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma
作者: Miao, Chengli1,2; Liu, Ding3; Zhang, Feng4,5; Wang, Youxin6; Zhang, Yanbin2; Yu, Junhui2; Zhang, Zhanzhi2; Liu, Gang2; Li, Bing2; Liu, Xing2; Luo, Chenghua1
刊名: SCIENTIFIC REPORTS
发表日期: 2015-03-13
DOI: 10.1038/srep09079
卷: 5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: HUMAN LEUKEMIA SUBLINES ; SYNTHETASE-ACTIVITY ; FOLATE ; CHROMOSOMES ; RESISTANCE ; MECHANISM ; LINKAGE ; TUMORS ; CELL
英文摘要:

Primary retroperitoneal liposarcoma is generally regarded as a genetic disorder. We have retrospectively genotyped 8 single nucleotide polymorphisms (SNPs) in 6 candidate genes (MDM2, CDK4, CDC27, FPGS, IGFN1, and PRAMEF13) in 138 patients and 131 healthy control subjects to evaluate the effects of genetic factors on individual susceptibility to primary retroperitoneal liposarcoma in Chinese population. Three SNPs (rs2870820, rs1695147, rs3730536) of MDM2 showed significant differences in single-loci genotypes and allele frequencies between case and control groups (p < 0.05). The minor allele G of SNP rs10760502 in FPGS (folylpolyglutamate synthase) gene was significantly associated with increased risk for primary retroperitoneal liposarcoma, compared with major allele A. Our data suggest that FPGS variant in Chinese population may affect individual susceptibility to primary retroperitoneal liposarcoma.

语种: 英语
所属项目编号: 81372586 ; Z11107067311063 ; YETP1671 ; Z141107001814058
项目资助者: National Science Foundation of China ; Beijing Capital Cultivate Public Health Projects ; Beijing Higher Education Young Elite Teacher Project ; Beijing Nova Program
WOS记录号: WOS:000351149500010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60696
Appears in Collections:北京大学国际医院_期刊论文

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作者单位: 1.Peking Univ, Int Hosp, Retroperitoneal Tumors Ctr, Beijing 100871, Peoples R China
2.Capital Med Univ, Beijing Shijitan Hosp, Affiliated Hosp Peking Univ 9, Dept Surg Oncol, Beijing, Peoples R China
3.Cent S Univ, Hosp Xiangya 3, Dept Neurol, Changsha, Hunan, Peoples R China
4.NE Normal Univ, Natl Engn Lab Druggable Gene & Prot Screening, Changchun 130024, Peoples R China
5.Chinese Acad Sci, Beijing Inst Genom, Chinese Acad Sci Key Lab Genome Sci & Informat, Beijing, Peoples R China
6.Capital Med Univ, Sch Publ Hlth, Beijing Municipal Key Lab Clin Epidemiol, Beijing 100069, Peoples R China

Recommended Citation:
Miao, Chengli,Liu, Ding,Zhang, Feng,et al. Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma[J]. SCIENTIFIC REPORTS,2015,5.
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