IR@PKUHSC  > 北京大学国际医院
学科主题临床医学
Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma
Miao, Chengli1,2; Liu, Ding3; Zhang, Feng4,5; Wang, Youxin6; Zhang, Yanbin2; Yu, Junhui2; Zhang, Zhanzhi2; Liu, Gang2; Li, Bing2; Liu, Xing2; Luo, Chenghua1
刊名SCIENTIFIC REPORTS
2015-03-13
DOI10.1038/srep09079
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]HUMAN LEUKEMIA SUBLINES ; SYNTHETASE-ACTIVITY ; FOLATE ; CHROMOSOMES ; RESISTANCE ; MECHANISM ; LINKAGE ; TUMORS ; CELL
英文摘要

Primary retroperitoneal liposarcoma is generally regarded as a genetic disorder. We have retrospectively genotyped 8 single nucleotide polymorphisms (SNPs) in 6 candidate genes (MDM2, CDK4, CDC27, FPGS, IGFN1, and PRAMEF13) in 138 patients and 131 healthy control subjects to evaluate the effects of genetic factors on individual susceptibility to primary retroperitoneal liposarcoma in Chinese population. Three SNPs (rs2870820, rs1695147, rs3730536) of MDM2 showed significant differences in single-loci genotypes and allele frequencies between case and control groups (p < 0.05). The minor allele G of SNP rs10760502 in FPGS (folylpolyglutamate synthase) gene was significantly associated with increased risk for primary retroperitoneal liposarcoma, compared with major allele A. Our data suggest that FPGS variant in Chinese population may affect individual susceptibility to primary retroperitoneal liposarcoma.

语种英语
WOS记录号WOS:000351149500010
项目编号81372586 ; Z11107067311063 ; YETP1671 ; Z141107001814058
资助机构National Science Foundation of China ; Beijing Capital Cultivate Public Health Projects ; Beijing Higher Education Young Elite Teacher Project ; Beijing Nova Program
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60696
专题北京大学国际医院
作者单位1.Peking Univ, Int Hosp, Retroperitoneal Tumors Ctr, Beijing 100871, Peoples R China
2.Capital Med Univ, Beijing Shijitan Hosp, Affiliated Hosp Peking Univ 9, Dept Surg Oncol, Beijing, Peoples R China
3.Cent S Univ, Hosp Xiangya 3, Dept Neurol, Changsha, Hunan, Peoples R China
4.NE Normal Univ, Natl Engn Lab Druggable Gene & Prot Screening, Changchun 130024, Peoples R China
5.Chinese Acad Sci, Beijing Inst Genom, Chinese Acad Sci Key Lab Genome Sci & Informat, Beijing, Peoples R China
6.Capital Med Univ, Sch Publ Hlth, Beijing Municipal Key Lab Clin Epidemiol, Beijing 100069, Peoples R China
推荐引用方式
GB/T 7714
Miao, Chengli,Liu, Ding,Zhang, Feng,et al. Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma[J]. SCIENTIFIC REPORTS,2015,5.
APA Miao, Chengli.,Liu, Ding.,Zhang, Feng.,Wang, Youxin.,Zhang, Yanbin.,...&Luo, Chenghua.(2015).Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma.SCIENTIFIC REPORTS,5.
MLA Miao, Chengli,et al."Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma".SCIENTIFIC REPORTS 5(2015).
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