北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Gut microbiota and probiotics in colon tumorigenesis
作者: Zhu, Yuanmin2; Luo, T. Michelle4; Jobin, Christian3; Young, Howard A.1
关键词: Microbiota ; Inflammation ; Probiotics ; Colorectal cancer
刊名: CANCER LETTERS
发表日期: 2011-10-28
DOI: 10.1016/j.canlet.2011.06.004
卷: 309, 期:2, 页:119-127
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: LACTOBACILLUS-RHAMNOSUS ; COLORECTAL-CANCER ; BIFIDOBACTERIUM-LACTIS ; INTESTINAL MICROBIOTA ; ULCERATIVE-COLITIS ; ANTITUMOR-ACTIVITY ; ESCHERICHIA-COLI ; RESISTANT STARCH ; FED INFANTS ; IN-VIVO
英文摘要:

The human gastrointestinal tract harbors a complex and abundant microbial community reaching as high as 10(13)-10(14) microorganisms in the colon. This endogenous microbiota forms a symbiotic relationship with their eukaryotic host and this close partnership helps maintain homeostasis by performing essential and non-redundant tasks (e.g. nutrition/energy and, immune system balance, pathogen exclusion). Although this relationship is essential and beneficial to the host, various events (e.g. infection, diet, stress, inflammation) may impact microbial composition, leading to the formation of a dysbiotic microbiota, further impacting on health and disease states. For example, Crohn′s disease and ulcerative colitis, collectively termed inflammatory bowel diseases (IBD), have been associated with the establishment of a dysbiotic microbiota. In addition, extra-intestinal disorders such as obesity and metabolic syndrome are also associated with the development of a dysbiotic microbiota. Consequently, there is an increasing interest in harnessing the power of the microbiome and modulating its composition as a means to alleviate intestinal pathologies/disorders and maintain health status. In this review, we will discuss the emerging relationship between the microbiota and development of colorectal cancer as well as present evidence that microbial manipulation (probiotic, prebiotic) impacts disease development. Published by Elsevier Ireland Ltd.

语种: 英语
所属项目编号: HHSN261200800001E
项目资助者: NIH ; National Cancer Institute ; Center for Cancer Research
WOS记录号: WOS:000294576400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60698
Appears in Collections:北京大学第二临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Natl Canc Inst, Ctr Canc Res, Canc & Inflammat Program, Expt Immunol Lab, Frederick, MD 21702 USA
2.Beijing Univ, Peoples Hosp, Dept Digest Dis, Beijing 100871, Peoples R China
3.Univ N Carolina, Div Gastroenterol & Hepatol, Chapel Hill, NC USA
4.US FDA, CDRH, OIVD, Silver Spring, MD USA

Recommended Citation:
Zhu, Yuanmin,Luo, T. Michelle,Jobin, Christian,et al. Gut microbiota and probiotics in colon tumorigenesis[J]. CANCER LETTERS,2011,309(2):119-127.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhu, Yuanmin]'s Articles
[Luo, T. Michelle]'s Articles
[Jobin, Christian]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhu, Yuanmin]‘s Articles
[Luo, T. Michelle]‘s Articles
[Jobin, Christian]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace