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Gut microbiota and probiotics in colon tumorigenesis
Zhu, Yuanmin2; Luo, T. Michelle4; Jobin, Christian3; Young, Howard A.1
关键词Microbiota Inflammation Probiotics Colorectal cancer
刊名CANCER LETTERS
2011-10-28
DOI10.1016/j.canlet.2011.06.004
309期:2页:119-127
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]LACTOBACILLUS-RHAMNOSUS ; COLORECTAL-CANCER ; BIFIDOBACTERIUM-LACTIS ; INTESTINAL MICROBIOTA ; ULCERATIVE-COLITIS ; ANTITUMOR-ACTIVITY ; ESCHERICHIA-COLI ; RESISTANT STARCH ; FED INFANTS ; IN-VIVO
英文摘要

The human gastrointestinal tract harbors a complex and abundant microbial community reaching as high as 10(13)-10(14) microorganisms in the colon. This endogenous microbiota forms a symbiotic relationship with their eukaryotic host and this close partnership helps maintain homeostasis by performing essential and non-redundant tasks (e.g. nutrition/energy and, immune system balance, pathogen exclusion). Although this relationship is essential and beneficial to the host, various events (e.g. infection, diet, stress, inflammation) may impact microbial composition, leading to the formation of a dysbiotic microbiota, further impacting on health and disease states. For example, Crohn′s disease and ulcerative colitis, collectively termed inflammatory bowel diseases (IBD), have been associated with the establishment of a dysbiotic microbiota. In addition, extra-intestinal disorders such as obesity and metabolic syndrome are also associated with the development of a dysbiotic microbiota. Consequently, there is an increasing interest in harnessing the power of the microbiome and modulating its composition as a means to alleviate intestinal pathologies/disorders and maintain health status. In this review, we will discuss the emerging relationship between the microbiota and development of colorectal cancer as well as present evidence that microbial manipulation (probiotic, prebiotic) impacts disease development. Published by Elsevier Ireland Ltd.

语种英语
WOS记录号WOS:000294576400001
项目编号HHSN261200800001E
资助机构NIH ; National Cancer Institute ; Center for Cancer Research
引用统计
被引频次:88[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60698
专题北京大学第二临床医学院
作者单位1.Natl Canc Inst, Ctr Canc Res, Canc & Inflammat Program, Expt Immunol Lab, Frederick, MD 21702 USA
2.Beijing Univ, Peoples Hosp, Dept Digest Dis, Beijing 100871, Peoples R China
3.Univ N Carolina, Div Gastroenterol & Hepatol, Chapel Hill, NC USA
4.US FDA, CDRH, OIVD, Silver Spring, MD USA
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GB/T 7714
Zhu, Yuanmin,Luo, T. Michelle,Jobin, Christian,et al. Gut microbiota and probiotics in colon tumorigenesis[J]. CANCER LETTERS,2011,309(2):119-127.
APA Zhu, Yuanmin,Luo, T. Michelle,Jobin, Christian,&Young, Howard A..(2011).Gut microbiota and probiotics in colon tumorigenesis.CANCER LETTERS,309(2),119-127.
MLA Zhu, Yuanmin,et al."Gut microbiota and probiotics in colon tumorigenesis".CANCER LETTERS 309.2(2011):119-127.
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