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Quantitative serum HBsAg and HBeAg are strong predictors of sustained HBeAg seroconversion to pegylated interferon alfa-2b in HBeAg-positive patients
Ma, Hui; Yang, Rui-feng; Wei, Lai
关键词HBeAg HBsAg hepatitis B interferon
刊名JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2010-09-01
DOI10.1111/j.1440-1746.2010.06282.x
25期:9页:1498-1506
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]CHRONIC HEPATITIS-B ; TERM-FOLLOW-UP ; 4 YEARS POSTTREATMENT ; PEGINTERFERON ALPHA-2A ; VIROLOGICAL RESPONSE ; CONTROLLED TRIAL
英文摘要

Background and Aim:

To evaluate the usefulness of quantitative hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) for predicting HBeAg seroconversion in chronic hepatitis B patients treated with conventional interferon (IFN) alfa-2b or PegIFN alfa-2b.

Methods:

Fifty-eight patients were enrolled; 29 for the training group and 29 for the validating group. Quantification of HBsAg and HBeAg was carried out at baseline, week 12, week 24, and then again at 12 and 24 weeks follow up, respectively, for two groups. Sixteen patients in the training group were followed up for 5 years.

Results:

The cutoff of 1500 IU/mL in serum HBsAg at week 12 had a positive predictive value (PPV) of 33% and a negative predictive value (NPV) of 91%, and 2890 IU/mL at week 24 had a PPV of 43% and an NPV of 95% for HBeAg seroconversion at week 48. The cutoff of 17.55 Paul Ehrlich Institute units/mL (PEI-U/mL) in serum HBeAg at week 12 had a PPV of 38% and an NPV of 95%, and 8.52 PEI-U/mL at week 24 had a PPV of 44% and a NPV of 100% for HBeAg seroconversion at week 48. Moreover the HBsAg and HBeAg levels of PegIFN alfa-2b group were lower than those of the conventional IFN alfa-2b group. During follow up, patients with HBeAg seroconversion remained HBeAg negative and none of them progressed to cirrhosis, but among the patients with non-HBeAg seroconversion, two progressed to cirrhosis. Two additional patients with negative HBeAg were observed.

Conclusions:

On-treatment serum HBsAg and HBeAg had high predictive values to predict sustained HBeAg seroconversion by PegIFN alfa-2b. Patients who cleared HBeAg had better survival free of hepatic complications during long-term follow-up study.

语种英语
WOS记录号WOS:000281218000009
项目编号2005CB522902 ; 2007CB512900 ; 2006AA02A410 ; 30571639 ; 2008ZX10002-012 ; 2008ZX10002-013 ; RDC 2009-13
资助机构Chinese Basic Research Foundation ; 863 program ; NSFC ; National Science and Technology Major Project for Infectious Diseases Control ; Peking University ; Key Clinical Research Program of Ministry of Health
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被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60701
专题北京大学第二临床医学院_肝病科
北京大学第二临床医学院_北京大学肝病研究所
作者单位Peking Univ, Inst Hepatol, Peking Univ Peoples Hosp, Beijing 100044, Peoples R China
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Ma, Hui,Yang, Rui-feng,Wei, Lai. Quantitative serum HBsAg and HBeAg are strong predictors of sustained HBeAg seroconversion to pegylated interferon alfa-2b in HBeAg-positive patients[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2010,25(9):1498-1506.
APA Ma, Hui,Yang, Rui-feng,&Wei, Lai.(2010).Quantitative serum HBsAg and HBeAg are strong predictors of sustained HBeAg seroconversion to pegylated interferon alfa-2b in HBeAg-positive patients.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,25(9),1498-1506.
MLA Ma, Hui,et al."Quantitative serum HBsAg and HBeAg are strong predictors of sustained HBeAg seroconversion to pegylated interferon alfa-2b in HBeAg-positive patients".JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 25.9(2010):1498-1506.
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