IR@PKUHSC  > 北京大学药学院
学科主题药学
Design and synthesis of guanidinoglycosides directed against the TAR RNA of HIV-1
Wang, M; Tu, PF; Xu, ZD; Yu, XL; Yang, M
刊名HELVETICA CHIMICA ACTA
2003
86期:7页:2637-2644
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]HUMAN-IMMUNODEFICIENCY-VIRUS ; TYPE-1 GENE-EXPRESSION ; BINDING ; TRANSACTIVATION
英文摘要

Replication of human immunodeficiency virus type 1 (HIV-1) requires specific interactions of the Tat protein with the transactivation responsive region (TAR) RNA. Tat-TAR RNA Interaction is mediated by a short arginine-rich domain of the protein. Disruption of this interaction could, in theory, create a state of complete viral latency. Here, four novel 6-amino-6-deoxytrehalose guanidinoglycoside derivatives (10 and 13-15) as target molecules have been designed to bind to TAR RNA for blocking the interaction of Tat-TAR RNA. They were obtained by coupling 6-amino-6-deoxy-alpha,alpha-trehalose (6) with the protected amino acids, deprotection by catalytic hydrogenation, followed by guanidinylated with S-methylisothiourea sulfate. Their abilities to inhibit Tat-TAR RNA interaction were determined by a Tat-dependent HIV-1 long terminal repeats (LTR)-driven chloramphenicol acetyltransferase (CAT) assays.

语种英语
WOS记录号WOS:000184797400029
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60706
专题北京大学药学院
作者单位1.Peking Univ, Natl Res Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, M,Tu, PF,Xu, ZD,et al. Design and synthesis of guanidinoglycosides directed against the TAR RNA of HIV-1[J]. HELVETICA CHIMICA ACTA,2003,86(7):2637-2644.
APA Wang, M,Tu, PF,Xu, ZD,Yu, XL,&Yang, M.(2003).Design and synthesis of guanidinoglycosides directed against the TAR RNA of HIV-1.HELVETICA CHIMICA ACTA,86(7),2637-2644.
MLA Wang, M,et al."Design and synthesis of guanidinoglycosides directed against the TAR RNA of HIV-1".HELVETICA CHIMICA ACTA 86.7(2003):2637-2644.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, M]的文章
[Tu, PF]的文章
[Xu, ZD]的文章
百度学术
百度学术中相似的文章
[Wang, M]的文章
[Tu, PF]的文章
[Xu, ZD]的文章
必应学术
必应学术中相似的文章
[Wang, M]的文章
[Tu, PF]的文章
[Xu, ZD]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。