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学科主题: 临床医学
题名:
Triple combinations of neuraminidase inhibitors, statins and fibrates benefit the survival of patients with lethal avian influenza pandemic
作者: An, Shu-Chang1; Xu, Li-Li2,3,4; Li, Feng-Di2,3,4; Bao, Lin-Lin2,3,4; Qin, Chuan2,3,4; Gao, Zhan-Cheng1
刊名: MEDICAL HYPOTHESES
发表日期: 2011-12-01
DOI: 10.1016/j.mehy.2011.09.001
卷: 77, 期:6, 页:1054-1057
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: A H5N1 INFECTION ; TRANSCRIPTION FACTORS ; VIRUS-INFECTION ; INFLAMMATION ; CELLS ; HMG-1 ; LIPOPOLYSACCHARIDE ; FENOFIBRATE ; EXPRESSION ; RESISTANCE
英文摘要:

The high mortality of highly pathogenic avian influenza A (H5N1) viruses infection in humans gives rise to considerable concern that it might someday cause another lethal pandemic. At present there is no other effective alternative besides the early and enough administration of neuraminidase inhibitors, which may be crucial for the patient management. However, its efficacy is sometimes limited because of the late administration in some patients especially the seriously ill ones and the continual occurrence of oseltamivir resistant A (H5N1) strains. The specific candidate vaccine are still under development and the practical value of passive immunization is hard to be widely applied because of the scarcity of convalescent human plasma, especially in the early stage of a serious and rapidly progressing pandemic. Statins and fibrates, both of which are used in clinical practice, have anti-inflammatory and immunomodulatory effects and other multiple biologic activities. So we hypothesized that the two immunomodulatory agents may exhibit synergistic effects when they were combined to neuraminidase inhibitors to treat the A (H5N1) viruses infections via inhibiting the production of either the early inflammatory mediators (e.g., many cytokine/chemokine) or the late mediator (e.g., High Mobility Group Box Protein 1), even showing the anti-viral activities with the prevention of the development of antiviral resistance. Therefore, the novel triple combinations may be an optimal management to confront the next lethal influenza pandemic on its very beginning. (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2009ZX10004-016
项目资助者: Ministry of Science and Technology of China
WOS记录号: WOS:000297400600031
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60708
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Resp & Crit Care Med, Beijing 100044, Peoples R China
2.Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing 100021, Peoples R China
3.PUMC, Comparat Med Ctr, Beijing 100021, Peoples R China
4.Minist Hlth, Key Lab Human Dis Comparat Med, Beijing 100021, Peoples R China

Recommended Citation:
An, Shu-Chang,Xu, Li-Li,Li, Feng-Di,et al. Triple combinations of neuraminidase inhibitors, statins and fibrates benefit the survival of patients with lethal avian influenza pandemic[J]. MEDICAL HYPOTHESES,2011,77(6):1054-1057.
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