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Serum peptidome profiling analysis for the identification of potential biomarkers in cervical intraepithelial neoplasia patients
Liu, Yun1; Wei, Fangqiao2; Wang, Feng3; Li, Changdong1; Meng, Ge1; Duan, Hua1; Ma, Qingwei3; Zhang, Weiyuan1
关键词CIN Peptidome WCC-MB
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2015-09-25
DOI10.1016/j.bbrc.2015.08.042
465期:3页:476-480
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]SPECTROMETRY-BASED SERUM ; HUMAN-PAPILLOMAVIRUS ; MASS-SPECTROMETRY ; BREAST-CANCER ; COMPLEMENT ACTIVATION ; COLORECTAL-CANCER ; SELDI-TOF ; DIAGNOSIS ; C4D ; MS
英文摘要

Cervical intraepithelial neoplasia (CIN) is a precancerous disease of cervical squamous cell carcinoma. We Used Mass Spectrometry based peptidome profile study to predict the transformation of CIN1, which is the primary stage of this lesion.. Serum samples of 34 Cervical squamous cell carcinoma patients, 31 healthy controls, and 29 CIN1 samples were analyzed. Peptides were purified by WCX magnetic beads (Bioyong), and analyzed by MALDI TOF (Bruker). Raw data were analyzed by BioExplorer software (Bioyong). The results showed 14 mass peaks with significant differences. The diagnosis model is established by analyzing peptide profiles of 15 SCC patients and 20 healthy women serum, with a sensitivity of 100% and specificity of 100.00%. In validation set, the SCC diagnosis model also had good performance with a sensitivity of 80%, a specificity of 100%. In addition, this model could predict 29 CIN1 patients with accuracy of 55.17%. These results would provide a new method to predict the trend of CIN1 and take effective measures for high risk group timely. (C) 2015 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000361418300026
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60713
专题北京大学口腔医学院_口腔预防保健科
北京大学临床肿瘤学院_核医学科
作者单位1.Bioyong Technol Inc, Beijing, Peoples R China
2.Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing 100028, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Prevent Dent, Beijing 100871, Peoples R China
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GB/T 7714
Liu, Yun,Wei, Fangqiao,Wang, Feng,et al. Serum peptidome profiling analysis for the identification of potential biomarkers in cervical intraepithelial neoplasia patients[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,465(3):476-480.
APA Liu, Yun.,Wei, Fangqiao.,Wang, Feng.,Li, Changdong.,Meng, Ge.,...&Zhang, Weiyuan.(2015).Serum peptidome profiling analysis for the identification of potential biomarkers in cervical intraepithelial neoplasia patients.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,465(3),476-480.
MLA Liu, Yun,et al."Serum peptidome profiling analysis for the identification of potential biomarkers in cervical intraepithelial neoplasia patients".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 465.3(2015):476-480.
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