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Mast cells or not?-CD117 positive cells in esophageal leiomyoma
Ye, Ju Xiang; Liu, Yan; Qin, Yun; Ma, Xiao Long; Zhong, Hao Hao; Zhang, Yan; Shi, Xue Ying
关键词Esophagus GIST Leiomyoma Mast cell CD117
刊名HISTOLOGY AND HISTOPATHOLOGY
2015-05-01
DOI10.14670/HH-30.581
30期:5页:581-588
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Pathology
研究领域[WOS]Cell Biology ; Pathology
关键词[WOS]GASTROINTESTINAL STROMAL TUMORS ; C-KIT GENE ; INTERSTITIAL-CELLS ; DIFFERENTIAL-DIAGNOSIS ; CAJAL ; EXPERIENCE ; MANAGEMENT ; UTERUS ; CD117
英文摘要

The presence of CD117 positive cells in esophageal leiomyoma may lead to a misdiagnosis of GIST. We reviewed 46 esophageal tumors which were smooth muscle tumors or GIST. Based on morphology, immunohistochemistry and mutation analysis, there were 44 (95.6%) leiomyomas, 1 (2.2%) leiomyosarcoma, and 1 (2.2%) GIST. Variable numbers of CD117 positive cells were seen in all leiomyomas. Tryptase immunostaining identified mast cells in 93.2% (41/44) of leiomyomas, and the number of mast cells per tumor decreased significantly from tumors of the upper esophagus to the esophageal-gastric junction (p<0.01). Immunofluorescence study further confirmed the presence of two types of CD117 positive spindle cells which included spindle-shaped mast cells and DOG-1-positive interstitial cells of Cajal. This is the first study to systemically review mast cells in esophageal leiomyomas and tumors which may be included in the differential diagnosis. We demonstrate that both spindled mast cells and hyperplastic interstitial cells of Cajal are present within esophageal leiomyomas. The immunoreactivity of these cells with CD117 may suggest a diagnosis of GIST, but the presence of mast cells itself supports a diagnosis of esophageal leiomyoma.

语种英语
WOS记录号WOS:000352500300008
项目编号2013YQ0365108
资助机构National Key Scientific Instruments and Equipment Development Program of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60714
专题北京大学第三临床医学院
作者单位Peking Univ, Hosp 3, Hlth Sci Ctr, Dept Pathol,Sch Basic Med Sci, Beijing 100191, Peoples R China
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GB/T 7714
Ye, Ju Xiang,Liu, Yan,Qin, Yun,et al. Mast cells or not?-CD117 positive cells in esophageal leiomyoma[J]. HISTOLOGY AND HISTOPATHOLOGY,2015,30(5):581-588.
APA Ye, Ju Xiang.,Liu, Yan.,Qin, Yun.,Ma, Xiao Long.,Zhong, Hao Hao.,...&Shi, Xue Ying.(2015).Mast cells or not?-CD117 positive cells in esophageal leiomyoma.HISTOLOGY AND HISTOPATHOLOGY,30(5),581-588.
MLA Ye, Ju Xiang,et al."Mast cells or not?-CD117 positive cells in esophageal leiomyoma".HISTOLOGY AND HISTOPATHOLOGY 30.5(2015):581-588.
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