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学科主题: 临床医学
题名:
Mast cells or not?-CD117 positive cells in esophageal leiomyoma
作者: Ye, Ju Xiang; Liu, Yan; Qin, Yun; Ma, Xiao Long; Zhong, Hao Hao; Zhang, Yan; Shi, Xue Ying
关键词: Esophagus ; GIST ; Leiomyoma ; Mast cell ; CD117
刊名: HISTOLOGY AND HISTOPATHOLOGY
发表日期: 2015-05-01
DOI: 10.14670/HH-30.581
卷: 30, 期:5, 页:581-588
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Pathology
研究领域[WOS]: Cell Biology ; Pathology
关键词[WOS]: GASTROINTESTINAL STROMAL TUMORS ; C-KIT GENE ; INTERSTITIAL-CELLS ; DIFFERENTIAL-DIAGNOSIS ; CAJAL ; EXPERIENCE ; MANAGEMENT ; UTERUS ; CD117
英文摘要:

The presence of CD117 positive cells in esophageal leiomyoma may lead to a misdiagnosis of GIST. We reviewed 46 esophageal tumors which were smooth muscle tumors or GIST. Based on morphology, immunohistochemistry and mutation analysis, there were 44 (95.6%) leiomyomas, 1 (2.2%) leiomyosarcoma, and 1 (2.2%) GIST. Variable numbers of CD117 positive cells were seen in all leiomyomas. Tryptase immunostaining identified mast cells in 93.2% (41/44) of leiomyomas, and the number of mast cells per tumor decreased significantly from tumors of the upper esophagus to the esophageal-gastric junction (p<0.01). Immunofluorescence study further confirmed the presence of two types of CD117 positive spindle cells which included spindle-shaped mast cells and DOG-1-positive interstitial cells of Cajal. This is the first study to systemically review mast cells in esophageal leiomyomas and tumors which may be included in the differential diagnosis. We demonstrate that both spindled mast cells and hyperplastic interstitial cells of Cajal are present within esophageal leiomyomas. The immunoreactivity of these cells with CD117 may suggest a diagnosis of GIST, but the presence of mast cells itself supports a diagnosis of esophageal leiomyoma.

语种: 英语
所属项目编号: 2013YQ0365108
项目资助者: National Key Scientific Instruments and Equipment Development Program of China
WOS记录号: WOS:000352500300008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60714
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 3, Hlth Sci Ctr, Dept Pathol,Sch Basic Med Sci, Beijing 100191, Peoples R China

Recommended Citation:
Ye, Ju Xiang,Liu, Yan,Qin, Yun,et al. Mast cells or not?-CD117 positive cells in esophageal leiomyoma[J]. HISTOLOGY AND HISTOPATHOLOGY,2015,30(5):581-588.
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