北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 病原生物学系  > 期刊论文
学科主题: 基础医学
题名:
An unbalanced PD-L1/CD86 ratio in CD14(++)CD16(+) monocytes is correlated with HCV viremia during chronic HCV infection
作者: Zheng, Jiajia1,2; Liang, Hua3; Xu, Chunhui1; Xu, Qiang1; Zhang, Ting1; Shen, Tao1,4; Lu, Fengmin1,4
关键词: core antigen ; hepatitis C virus ; monocytes ; PD-L1/CD86 ; viral load
刊名: CELLULAR & MOLECULAR IMMUNOLOGY
发表日期: 2014-05-01
DOI: 10.1038/cmi.2013.70
卷: 11, 期:3, 页:294-304
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: HEPATITIS-C VIRUS ; T-CELL EXHAUSTION ; DENDRITIC CELLS ; DISEASE PROGRESSION ; IMMUNE-RESPONSES ; BLOOD MONOCYTES ; VIRAL-INFECTION ; PD-1 EXPRESSION ; B7 FAMILY ; CONSEQUENCE
英文摘要:

Circulating monocyte subsets with distinct functions play important roles in hepatitis C virus (HCV) infection. However, the mechanisms have not been well studied. In this study, we analyzed the distributions and phenotypic characteristics of three circulating monocyte subsets-CD14(++)CD16(-), CD14(++)CD16(+) and CD14(+/dim)CD16(+)-in chronic HCV-infected patients, HCV spontaneous resolvers and healthy controls, and we evaluated the possible link between HCV viremia and disease progression. Our results indicated that the frequency of the CD14(++)CD16(+) monocyte subset was decreased, and negatively correlated with HCV RNA and core antigen levels during chronic HCV infection. PD-L1 expression and the PD-L1/CD86 ratio in CD14(++)CD16(+) monocytes were higher during chronic HCV infection than in spontaneous HCV resolvers and healthy controls. The PD-L1/CD86 ratio positively correlated with HCV viral load and core antigen levels. Finally, PD-L1 was significantly increased, while cytokine secretions were dramatically decreased upon Toll-like receptor (TLR) ligand binding and HCV JFH-1stimulation. These findings indicates the compromised immune status of the CD14(++)CD16(+) monocytes during chronic HCV infection and provides new insights into the specific role of the CD14(++)CD16(+) monocytes and their significance in chronic HCV infection.

语种: 英语
所属项目编号: 81271826 ; 31100126 ; 7122108 ; 2011SKLID207 ; 2012ZX10002003 ; 2012ZX10002005
项目资助者: National Natural Science of China ; National Science Foundation of Beijing ; SKLID development grant ; National S& ; T Major Project for Infectious Diseases
WOS记录号: WOS:000335374000011
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60718
Appears in Collections:基础医学院_病原生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
An unbalanced PD-L1 CD86 ratio in CD14(++)CD16(+) monocytes is correlated with HCV viremia during chronic HCV infection.pdf(2285KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Lab Med, Beijing 100191, Peoples R China
3.China CDC, Natl Ctr AIDS STD Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing, Peoples R China
4.Peking Univ, Ctr Infect Dis, Beijing 100191, Peoples R China

Recommended Citation:
Zheng, Jiajia,Liang, Hua,Xu, Chunhui,et al. An unbalanced PD-L1/CD86 ratio in CD14(++)CD16(+) monocytes is correlated with HCV viremia during chronic HCV infection[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2014,11(3):294-304.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zheng, Jiajia]'s Articles
[Liang, Hua]'s Articles
[Xu, Chunhui]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zheng, Jiajia]‘s Articles
[Liang, Hua]‘s Articles
[Xu, Chunhui]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace