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学科主题: 基础医学
题名:
An unbalanced PD-L1/CD86 ratio in CD14(++)CD16(+) monocytes is correlated with HCV viremia during chronic HCV infection
作者: Zheng, Jiajia1,2; Liang, Hua3; Xu, Chunhui1; Xu, Qiang1; Zhang, Ting1; Shen, Tao1,4; Lu, Fengmin1,4
关键词: core antigen ; hepatitis C virus ; monocytes ; PD-L1/CD86 ; viral load
刊名: CELLULAR & MOLECULAR IMMUNOLOGY
发表日期: 2014-05-01
DOI: 10.1038/cmi.2013.70
卷: 11, 期:3, 页:294-304
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: HEPATITIS-C VIRUS ; T-CELL EXHAUSTION ; DENDRITIC CELLS ; DISEASE PROGRESSION ; IMMUNE-RESPONSES ; BLOOD MONOCYTES ; VIRAL-INFECTION ; PD-1 EXPRESSION ; B7 FAMILY ; CONSEQUENCE
英文摘要:

Circulating monocyte subsets with distinct functions play important roles in hepatitis C virus (HCV) infection. However, the mechanisms have not been well studied. In this study, we analyzed the distributions and phenotypic characteristics of three circulating monocyte subsets-CD14(++)CD16(-), CD14(++)CD16(+) and CD14(+/dim)CD16(+)-in chronic HCV-infected patients, HCV spontaneous resolvers and healthy controls, and we evaluated the possible link between HCV viremia and disease progression. Our results indicated that the frequency of the CD14(++)CD16(+) monocyte subset was decreased, and negatively correlated with HCV RNA and core antigen levels during chronic HCV infection. PD-L1 expression and the PD-L1/CD86 ratio in CD14(++)CD16(+) monocytes were higher during chronic HCV infection than in spontaneous HCV resolvers and healthy controls. The PD-L1/CD86 ratio positively correlated with HCV viral load and core antigen levels. Finally, PD-L1 was significantly increased, while cytokine secretions were dramatically decreased upon Toll-like receptor (TLR) ligand binding and HCV JFH-1stimulation. These findings indicates the compromised immune status of the CD14(++)CD16(+) monocytes during chronic HCV infection and provides new insights into the specific role of the CD14(++)CD16(+) monocytes and their significance in chronic HCV infection.

语种: 英语
所属项目编号: 81271826 ; 31100126 ; 7122108 ; 2011SKLID207 ; 2012ZX10002003 ; 2012ZX10002005
项目资助者: National Natural Science of China ; National Science Foundation of Beijing ; SKLID development grant ; National S& ; T Major Project for Infectious Diseases
WOS记录号: WOS:000335374000011
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60718
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Lab Med, Beijing 100191, Peoples R China
3.China CDC, Natl Ctr AIDS STD Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing, Peoples R China
4.Peking Univ, Ctr Infect Dis, Beijing 100191, Peoples R China

Recommended Citation:
Zheng, Jiajia,Liang, Hua,Xu, Chunhui,et al. An unbalanced PD-L1/CD86 ratio in CD14(++)CD16(+) monocytes is correlated with HCV viremia during chronic HCV infection[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2014,11(3):294-304.
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