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Relapse Induced by Cues Predicting Cocaine Depends on Rapid, Transient Synaptic Potentiation
Gipson, Cassandra D.1; Kupchik, Yonatan M.1; Shen, Haowei2; Reissner, Kathryn J.1; Thomas, Charles A.1; Kalivas, Peter W.1
刊名NEURON
2013-03-06
DOI10.1016/j.neuron.2013.01.005
77期:5页:867-872
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者National Institutes of Health ; National Institutes of Health
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]AMPA RECEPTOR TRAFFICKING ; LONG-TERM POTENTIATION ; DRUG-SEEKING BEHAVIOR ; NUCLEUS-ACCUMBENS ; PREFRONTAL CORTEX ; DENDRITIC SPINE ; PLASTICITY ; NEURONS ; CORE ; REINSTATEMENT
英文摘要

Cocaine addiction is characterized by long-lasting vulnerability to relapse arising because neutral environmental stimuli become associated with drug use and then act as cues that induce relapse. It is not known how cues elicit cocaine seeking, and why cocaine seeking is more difficult to regulate than seeking a natural reward. We found that cocaine-associated cues initiate cocaine seeking by inducing a rapid, transient increase in dendritic spine size and synaptic strength in the nucleus accumbens. These changes required neural activity in the prefrontal cortex. This is not the case when identical cues were associated with obtaining sucrose, which did not elicit changes in spine size or synaptic strength. The marked cue-induced synaptic changes in the accumbens were correlated with the intensity of cocaine, but not sucrose seeking, and may explain the difficulty addicts experience in managing relapse to cocaine use.

语种英语
所属项目编号DA007288 ; DA033690 ; DA003906 ; DA012513 ; DA015369
资助者National Institutes of Health ; National Institutes of Health
WOS记录号WOS:000316162600008
Citation statistics
Cited Times:73[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60721
Collection中国药物依赖性研究所
作者单位1.Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Gipson, Cassandra D.,Kupchik, Yonatan M.,Shen, Haowei,et al. Relapse Induced by Cues Predicting Cocaine Depends on Rapid, Transient Synaptic Potentiation[J]. NEURON,2013,77(5):867-872.
APA Gipson, Cassandra D.,Kupchik, Yonatan M.,Shen, Haowei,Reissner, Kathryn J.,Thomas, Charles A.,&Kalivas, Peter W..(2013).Relapse Induced by Cues Predicting Cocaine Depends on Rapid, Transient Synaptic Potentiation.NEURON,77(5),867-872.
MLA Gipson, Cassandra D.,et al."Relapse Induced by Cues Predicting Cocaine Depends on Rapid, Transient Synaptic Potentiation".NEURON 77.5(2013):867-872.
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