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学科主题: 药物依赖
题名:
Relapse Induced by Cues Predicting Cocaine Depends on Rapid, Transient Synaptic Potentiation
作者: Gipson, Cassandra D.1; Kupchik, Yonatan M.1; Shen, Haowei2; Reissner, Kathryn J.1; Thomas, Charles A.1; Kalivas, Peter W.1
刊名: NEURON
发表日期: 2013-03-06
DOI: 10.1016/j.neuron.2013.01.005
卷: 77, 期:5, 页:867-872
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: AMPA RECEPTOR TRAFFICKING ; LONG-TERM POTENTIATION ; DRUG-SEEKING BEHAVIOR ; NUCLEUS-ACCUMBENS ; PREFRONTAL CORTEX ; DENDRITIC SPINE ; PLASTICITY ; NEURONS ; CORE ; REINSTATEMENT
英文摘要:

Cocaine addiction is characterized by long-lasting vulnerability to relapse arising because neutral environmental stimuli become associated with drug use and then act as cues that induce relapse. It is not known how cues elicit cocaine seeking, and why cocaine seeking is more difficult to regulate than seeking a natural reward. We found that cocaine-associated cues initiate cocaine seeking by inducing a rapid, transient increase in dendritic spine size and synaptic strength in the nucleus accumbens. These changes required neural activity in the prefrontal cortex. This is not the case when identical cues were associated with obtaining sucrose, which did not elicit changes in spine size or synaptic strength. The marked cue-induced synaptic changes in the accumbens were correlated with the intensity of cocaine, but not sucrose seeking, and may explain the difficulty addicts experience in managing relapse to cocaine use.

语种: 英语
所属项目编号: DA007288 ; DA033690 ; DA003906 ; DA012513 ; DA015369
项目资助者: National Institutes of Health
WOS记录号: WOS:000316162600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60721
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China

Recommended Citation:
Gipson, Cassandra D.,Kupchik, Yonatan M.,Shen, Haowei,et al. Relapse Induced by Cues Predicting Cocaine Depends on Rapid, Transient Synaptic Potentiation[J]. NEURON,2013,77(5):867-872.
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