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学科主题医学信息学
hUbiquitome: a database of experimentally verified ubiquitination cascades in humans
Du, Yipeng1,2; Xu, Nanfang1,3; Lu, Ming1; Li, Tingting1,4
刊名DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
2011
DOI10.1093/database/bar055
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mathematical & Computational Biology
研究领域[WOS]Mathematical & Computational Biology
关键词[WOS]DEUBIQUITINATING ENZYMES ; PROTEIN-DEGRADATION ; MASS-SPECTROMETRY ; PROTEASOME SYSTEM ; LIGASES ; CONNECTION ; MECHANISMS ; CANCER ; FAMILY
英文摘要

Protein ubiquitination is an evolutionarily conserved and functionally diverse post-translational modification achieved through the sequential action of E1-activating enzymes, E2-conjugating enzymes and E3 ligases. A summary of validated ubiquitination substrates have been presented and a prediction of new substrates have been conducted in yeast. However, a systematic summary of human ubiquitination substrates containing experimental evidence and the enzymatic cascade of each substrate is not available. In the present study, hUbiquitome web resource is introduced, a public resource for the retrieval of experimentally verified human ubiquitination enzymes and substrates. hUbiquitome is the first comprehensive database of human ubiquitination cascades. Currently, hUbiquitome has in its repertoire curated data comprising 1 E1 enzyme, 12 E2 enzymes, 138 E3 ligases or complexes, 279 different substrate proteins and 17 deubiquitination enzyme terms. The biological functions of substrates from different kinds of E3s were analyzed using the collected data. The findings show that substrates ubiquitinated by RING (Really Interesting New Gene) E3s are enriched most in apoptosis-related processes, whereas substrates ubiquitinated by other E3s are enriched in gene expression-associated processes. An analysis of the data demonstrates the biological process preferences of the different kinds of E3s. hUbiquitome is the first database to systematically collect experimentally validated ubiquitinated proteins and related ubiquitination cascade enzymes which might be helpful in the field of ubiquitination-modification research.

Database URL: http://202.38.126.151/hmdd/hubi/

语种英语
WOS记录号WOS:000299630600057
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60722
Collection北京大学基础医学院_医学信息学系
北京大学基础医学院
北京大学第三临床医学院_呼吸科
作者单位1.Peking Univ, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Med Informat, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Biochem & Mol Biol, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Inst Syst Biomed, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Du, Yipeng,Xu, Nanfang,Lu, Ming,et al. hUbiquitome: a database of experimentally verified ubiquitination cascades in humans[J]. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION,2011.
APA Du, Yipeng,Xu, Nanfang,Lu, Ming,&Li, Tingting.(2011).hUbiquitome: a database of experimentally verified ubiquitination cascades in humans.DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.
MLA Du, Yipeng,et al."hUbiquitome: a database of experimentally verified ubiquitination cascades in humans".DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2011).
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