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Copy number variations of the human histamine H4 receptor gene are associated with systemic lupus erythematosus
Yu, B.2,4; Shao, Y.2,4; Li, P.5; Zhang, J.2,4; Zhong, Q.2; Yang, H.3; Hu, X.2; Chen, B.2; Peng, X.2; Wu, Q.4; Chen, Y.1; Guan, M.6; Wan, J.7; Zhang, W.1,7
关键词copy number variations histamine H4 receptor systemic lupus erythematosus
刊名BRITISH JOURNAL OF DERMATOLOGY
2010-11-01
DOI10.1111/j.1365-2133.2010.09928.x
163期:5页:935-940
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dermatology
研究领域[WOS]Dermatology
关键词[WOS]COMPLEMENT COMPONENT C4 ; H-4 RECEPTOR ; RHEUMATOID-ARTHRITIS ; MAST-CELLS ; MEDIATES CHEMOTAXIS ; DENDRITIC CELLS ; SYNOVIAL-CELLS ; SUSCEPTIBILITY ; EXPRESSION ; DISEASE
英文摘要

Background Systemic lupus erythematosus (SLE) is a complex genetic disease; the histamine H4 receptor (HRH4) has been shown to be related to different kinds of autoimmune disorders; and copy number variations (CNVs) have been found to be associated with various types of diseases.

Objectives To explore a possible association between HRH4 (formerly H4R) CNVs and the risk of SLE.

Methods Genomic DNA and RNA from 340 patients with SLE and 392 healthy controls were extracted, and CNVs and mRNA levels of HRH4 were examined.

Results The expression of HRH4 mRNA was significantly increased in patients with SLE compared with controls. Amplification of HRH4 copy numbers significantly increased the risk of SLE [P < 0 001, odds ratio (OR) 2 26, 95% confidence interval (CI) 1.50-3.40]. HRH4 amplifications also positively correlated with the incidence of arthritis (P = 0.019, OR 1.96, 95% CI 1.11-3.47), and proteinuria (P < 0 001, OR 2.95, 95% CI 1.73-5.00) and antinuclear antibody abnormalities (P < 0 001, OR 2.97, 95% CI 1.66-5.33). Deletions of HRH4 copy numbers were protective against proteinuria (P = 0 03, OR 0.50, 95% CI 0.26-0.94).

Conclusion CNVs of the HRH4 gene are associated with SLE.

语种英语
WOS记录号WOS:000283597500007
项目编号200802008 ; 08fz-09
资助机构Shenzhen Science and Technology Project
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60729
专题北京大学深圳医院_皮肤性病科
北京大学第二临床医学院_呼吸科
北京大学临床肿瘤学院_内镜中心
作者单位1.Shenzhen Hosp Peking Univ, Clin Lab, Shenzhen, Guangdong, Peoples R China
2.Huashan Hosp, Clin Lab, Shanghai, Peoples R China
3.Ji Nan Univ, JNU HKUST Joint Lab, Guangzhou 510632, Guangdong, Peoples R China
4.Shenzhen Hosp Peking Univ, Dept Dermatol, Shenzhen, Guangdong, Peoples R China
5.Shenzhen PKU HKUST Med Ctr 1120, Biomed Res Inst, Shenzhen 518036, Guangdong, Peoples R China
6.Shenzhen Childrens Hosp, Dept Dermatol, Shenzhen, Guangdong, Peoples R China
7.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Yu, B.,Shao, Y.,Li, P.,et al. Copy number variations of the human histamine H4 receptor gene are associated with systemic lupus erythematosus[J]. BRITISH JOURNAL OF DERMATOLOGY,2010,163(5):935-940.
APA Yu, B..,Shao, Y..,Li, P..,Zhang, J..,Zhong, Q..,...&Zhang, W..(2010).Copy number variations of the human histamine H4 receptor gene are associated with systemic lupus erythematosus.BRITISH JOURNAL OF DERMATOLOGY,163(5),935-940.
MLA Yu, B.,et al."Copy number variations of the human histamine H4 receptor gene are associated with systemic lupus erythematosus".BRITISH JOURNAL OF DERMATOLOGY 163.5(2010):935-940.
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