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学科主题基础医学
Immunoglobulin G expression and its colocalization with complement proteins in papillary thyroid cancer
Qiu, Yamei1; Korteweg, Christine1; Chen, Zhengshan1; Li, Jing1; Luo, Jin1; Huang, Guowei1; Gu, Jiang1,2
关键词activation-induced cytidine deaminase C1q immunoglobulin G RAG1 RAG2 papillary thyroid cancer
刊名MODERN PATHOLOGY
2012
25期:1页:36-45
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]INHIBITORY PROTEINS ; EPITHELIAL-CELLS ; GENE-EXPRESSION ; BREAST-CANCER ; CARCINOMAS ; GROWTH ; PROLIFERATION ; MANAGEMENT ; RECEPTORS ; LINES
英文摘要

Except for the well-known immunoglobulin G (IgG) producing cell types, ie, mature B lymphocytes and plasma cells, various non-lymphoid cell types, including human cancer cells, neurons, and some specified epithelial cells, have been found to express IgG. In this study, we detected the expression of the heavy chain of IgG (IgG gamma) and kappa light chain (Ig kappa) in papillary thyroid cancer cells. Using in situ hybridization, we detected the constant region of human IgG1 (IGHG1) in papillary thyroid cancer cells. With laser capture microdissection followed by RT-PCR, mRNA transcripts of IGHG1, Ig kappa, recombination activating gene 1 (RAG1), RAG2, and activation-induced cytidine deaminase genes were successfully amplified from isolated papillary thyroid cancer cells. We further confirmed IgG protein expression with immunohistochemistry and found that none of the IgG receptors was expressed in papillary thyroid cancer. Differences in the level of IgG gamma expression between tumor size, between papillary thyroid cancer and normal thyroid tissue, as well as between papillary thyroid cancer with and without lymph node metastasis were significant. Taken together, these results indicate that IgG is produced by papillary thyroid cancer cells and that it might be positively related to the growth and metastasis of papillary thyroid cancer cells. Furthermore, it was demonstrated that IgG gamma colocalized with complement proteins in the same cancer cells, which could indicate that immune complexes were formed. Such immune complexes might consist of IgG synthesized by the host against tumor surface antigens and locally produced anti-idiotypic IgG with specificity for the variable region of these ′primary′ antibodies. The cancer cells might thus escape the host tumor-antigen-specific immune responses, hence promoting tumor progression. Modern Pathology (2012) 25, 36-45; doi:10.1038/modpathol.2011.139; published online 9 September 2011

语种英语
WOS记录号WOS:000299020700004
项目编号81030033 ; 30971150 ; 81001199 ; 30950110335
资助机构National Natural Science Foundation of China
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60732
专题北京大学基础医学院_病理学系
作者单位1.Shantou Univ, Coll Med, Dept Pathol, Shantou 515041, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Qiu, Yamei,Korteweg, Christine,Chen, Zhengshan,et al. Immunoglobulin G expression and its colocalization with complement proteins in papillary thyroid cancer[J]. MODERN PATHOLOGY,2012,25(1):36-45.
APA Qiu, Yamei.,Korteweg, Christine.,Chen, Zhengshan.,Li, Jing.,Luo, Jin.,...&Gu, Jiang.(2012).Immunoglobulin G expression and its colocalization with complement proteins in papillary thyroid cancer.MODERN PATHOLOGY,25(1),36-45.
MLA Qiu, Yamei,et al."Immunoglobulin G expression and its colocalization with complement proteins in papillary thyroid cancer".MODERN PATHOLOGY 25.1(2012):36-45.
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