北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Potential involvement of miR-375 in the premalignant progression of oral squamous cell carcinoma mediated via transcription factor KLF5
作者: Shi, Wen1,2; Yang, Jing2; Li, Siyuan1; Shan, Xiaofeng1; Liu, Xiaosong3; Hua, Hong3; Zhao, Chuanke2; Feng, Zhendong2; Cai, Zhigang1; Zhang, Lihe2; Zhou, Demin2
关键词: miR-375 ; OSCC ; KLF5 ; OLP ; malignant progression
刊名: ONCOTARGET
发表日期: 2015-11-24
卷: 6, 期:37, 页:40172-40185
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Cell Biology
研究领域[WOS]: Oncology ; Cell Biology
关键词[WOS]: KRUPPEL-LIKE FACTOR-5 ; GENE-EXPRESSION ; TUMOR-SUPPRESSOR ; EPITHELIAL-CELLS ; MICRORNA EXPRESSION ; PROSTATE-CANCER ; LICHEN-PLANUS ; NECK-CANCER ; PROLIFERATION ; INFLAMMATION
英文摘要:

To elucidate the genetic effect involved in the premalignant progression of chronic inflammation to cancer, we performed microRNA and mRNA profiling in oral lichen planus (OLP), oral squamous cell carcinoma (OSCC), and normal tissue from the same patients. We demonstrate the involvement of a suppressive microRNA, miR-375, in the regulation of this premalignant progression via KLF5, a transcription factor that modulates the expression of genes contributing to proliferation and apoptosis. We found that miR-375 abundance decreased in tissues with progression from the normal state to OLP and subsequently to OSCC. Restoration of miR-375 by transduction of a synthetic mimic into OSCC cells repressed cellular proliferation and promoted apoptosis, with concomitant down-regulation of KLF5, and vice versa. The direct binding of miR-375 to the 3′-untranslated region of KLF5 was further confirmed. Additionally, Survivin (BIRC5), a target of KLF5, was also regulated by miR-375, explaining the susceptibility of miR-375-mimic transfected cells to apoptosis. Further analysis of clinical specimens suggested that expression of KLF5 and BIRC5 is up-regulated during the progression from inflammation to cancer. Our findings provide novel insights into the involvement of microRNAs in progression of inflammation to carcinoma and suggest a potential early-stage biomarker or therapy target for oral carcinoma.

语种: 英语
所属项目编号: 91029711 ; 81301970 ; 91429305
项目资助者: National Science Foundation of China (NSFC)
WOS记录号: WOS:000366114400061
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60733
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100871, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Oral Med, Beijing 100871, Peoples R China

Recommended Citation:
Shi, Wen,Yang, Jing,Li, Siyuan,et al. Potential involvement of miR-375 in the premalignant progression of oral squamous cell carcinoma mediated via transcription factor KLF5[J]. ONCOTARGET,2015,6(37):40172-40185.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Shi, Wen]'s Articles
[Yang, Jing]'s Articles
[Li, Siyuan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Shi, Wen]‘s Articles
[Yang, Jing]‘s Articles
[Li, Siyuan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace