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学科主题: 药学
题名:
Supramolecular Assembly Models of siRNA Delivery Systems
作者: Sun, Jing; Wang, Jiancheng; Yang, Zhenjun
关键词: siRNA delivery ; supramolecular assembly ; non-viral vectors ; nanocarriers
刊名: CHINESE JOURNAL OF CHEMISTRY
发表日期: 2015
DOI: 10.1002/cjoc.201400484
卷: 33, 期:1, 页:79-89
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: DOUBLE-STRANDED-RNA ; CELL-PENETRATING PEPTIDES ; CALCIUM-PHOSPHATE NANOPARTICLES ; MOLECULAR-WEIGHT POLYETHYLENIMINE ; NONVIRAL GENE DELIVERY ; SHORT HAIRPIN RNA ; IN-VIVO ; MAMMALIAN-CELLS ; CARBON NANOTUBES ; DRUG-DELIVERY
英文摘要:

Small interfering RNA (siRNA) technology, which could be able to silence specific targeted mRNAs rapidly and efficiently, has been regarded as a novel and potent gene therapeutic approach for diseases, such as cancers, infections, inflammations and neurological disorders. However, some conspicuous intrinsic defects of siRNA including the poor cellular uptake, low biological stability, unfavorable pharmacokinetics and bio-distribution properties, have hindered further applications in clinic. Therefore, it is prerequisite to design safe and effective siRNA delivery systems for the successful development of siRNA-based various diseases therapeutics. This review aims to analyze and summarize these supramolecular assembly models in the process of siRNA delivery, namely recent nanotechnological strategies for carrying siRNA by using diverse non-viral vehicles such as cationic liposomes, stable nucleic acid lipid particles (SNALPs), cationic polymers, cationic dendrimers, inorganic nanoparticles and others. Eventually, it is concluded with future perspectives of siRNA therapeutics in the field of non-viral carriers.

语种: 英语
所属项目编号: 2012CB720604 ; 2012AA022501 ; 20932001
项目资助者: Ministry of Science and Technology of China ; National Natural Science Foundation of China
WOS记录号: WOS:000348737600009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60734
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Sun, Jing,Wang, Jiancheng,Yang, Zhenjun. Supramolecular Assembly Models of siRNA Delivery Systems[J]. CHINESE JOURNAL OF CHEMISTRY,2015,33(1):79-89.
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