IR@PKUHSC  > 北京大学药学院
学科主题药学
Supramolecular Assembly Models of siRNA Delivery Systems
Sun, Jing; Wang, Jiancheng; Yang, Zhenjun
关键词siRNA delivery supramolecular assembly non-viral vectors nanocarriers
刊名CHINESE JOURNAL OF CHEMISTRY
2015
DOI10.1002/cjoc.201400484
33期:1页:79-89
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]DOUBLE-STRANDED-RNA ; CELL-PENETRATING PEPTIDES ; CALCIUM-PHOSPHATE NANOPARTICLES ; MOLECULAR-WEIGHT POLYETHYLENIMINE ; NONVIRAL GENE DELIVERY ; SHORT HAIRPIN RNA ; IN-VIVO ; MAMMALIAN-CELLS ; CARBON NANOTUBES ; DRUG-DELIVERY
英文摘要

Small interfering RNA (siRNA) technology, which could be able to silence specific targeted mRNAs rapidly and efficiently, has been regarded as a novel and potent gene therapeutic approach for diseases, such as cancers, infections, inflammations and neurological disorders. However, some conspicuous intrinsic defects of siRNA including the poor cellular uptake, low biological stability, unfavorable pharmacokinetics and bio-distribution properties, have hindered further applications in clinic. Therefore, it is prerequisite to design safe and effective siRNA delivery systems for the successful development of siRNA-based various diseases therapeutics. This review aims to analyze and summarize these supramolecular assembly models in the process of siRNA delivery, namely recent nanotechnological strategies for carrying siRNA by using diverse non-viral vehicles such as cationic liposomes, stable nucleic acid lipid particles (SNALPs), cationic polymers, cationic dendrimers, inorganic nanoparticles and others. Eventually, it is concluded with future perspectives of siRNA therapeutics in the field of non-viral carriers.

语种英语
WOS记录号WOS:000348737600009
项目编号2012CB720604 ; 2012AA022501 ; 20932001
资助机构Ministry of Science and Technology of China ; National Natural Science Foundation of China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60734
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
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Sun, Jing,Wang, Jiancheng,Yang, Zhenjun. Supramolecular Assembly Models of siRNA Delivery Systems[J]. CHINESE JOURNAL OF CHEMISTRY,2015,33(1):79-89.
APA Sun, Jing,Wang, Jiancheng,&Yang, Zhenjun.(2015).Supramolecular Assembly Models of siRNA Delivery Systems.CHINESE JOURNAL OF CHEMISTRY,33(1),79-89.
MLA Sun, Jing,et al."Supramolecular Assembly Models of siRNA Delivery Systems".CHINESE JOURNAL OF CHEMISTRY 33.1(2015):79-89.
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