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Association of the Common Genetic Variant Upstream of INSIG2 Gene with Obesity Related Phenotypes in Chinese Children and Adolescents
Wang, Hai-Jun2; Zhang, Heng1; Zhang, Shi-Wei1; Pan, Yong-Ping3; Ma, Jun1
关键词INSIG2 gene Obesity-related phenotypes Children and adolescents
刊名BIOMEDICAL AND ENVIRONMENTAL SCIENCES
2008-12-01
21期:6页:528-536
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences ; Public, Environmental & Occupational Health
资助者National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; Major State Basic Research and Development Program of China ; National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; Major State Basic Research and Development Program of China
研究领域[WOS]Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]RS7566605 POLYMORPHISM ; PROMOTER POLYMORPHISM ; NO ASSOCIATION ; BODY-WEIGHT ; POPULATION ; METABOLISM ; OVERWEIGHT ; PROTEINS ; JAPANESE
英文摘要

Objective To study the association between the rs7566605 variant of INSIG2 and obesity-related phenotypes in Chinese children and adolescents. Methods The study sample consisted of two independent cohorts of Chinese children and adolescents. Anthropometric indices, lipids, blood pressure, fasting glucose, insulin and percentage of fat mass were determined. PCR with restriction fragment length polymorphism analysis was performed for genotyping the rs7566605 variant. Results In each of the two independent cohorts, no significant association was observed between rs7566605 and obesity under additive, dominant or recessive model. We also did not detect any difference in the genotype frequency between all the obese children and controls. Furthermore, we did not find evidence of an association between body composition indices and metabolic phenotypes in all children. However, the triglyceride level of CC homozygotes was significantly higher than that of GG+GC genotypes in obese children (P=0.022). Additionally, we observed a non-significant trend of severe obesity in a post-hoc test. Conclusion INSIG2 rs7566605 variant is not associated Chinese childhood obesity in two independent cohorts. Further study is needed to verify the effect of rs7566605 on triglyceride in obese children.

语种英语
所属项目编号30700668 ; 20070001811 ; 2006CB503900
资助者National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; Major State Basic Research and Development Program of China ; National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; Major State Basic Research and Development Program of China
WOS记录号WOS:000262022700013
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60737
专题北京大学公共卫生学院
作者单位1.Peking Univ, Inst Child & Adolescent Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Maternal & Child Hlth, Beijing 100191, Peoples R China
3.Care Inst, Dongcheng Sch Hlth, Beijing 100005, Peoples R China
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Wang, Hai-Jun,Zhang, Heng,Zhang, Shi-Wei,et al. Association of the Common Genetic Variant Upstream of INSIG2 Gene with Obesity Related Phenotypes in Chinese Children and Adolescents[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2008,21(6):528-536.
APA Wang, Hai-Jun,Zhang, Heng,Zhang, Shi-Wei,Pan, Yong-Ping,&Ma, Jun.(2008).Association of the Common Genetic Variant Upstream of INSIG2 Gene with Obesity Related Phenotypes in Chinese Children and Adolescents.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,21(6),528-536.
MLA Wang, Hai-Jun,et al."Association of the Common Genetic Variant Upstream of INSIG2 Gene with Obesity Related Phenotypes in Chinese Children and Adolescents".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 21.6(2008):528-536.
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